Fetal Valproate Syndrome

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dc.contributor.authorMutlu-Albayrak, Hatice
dc.contributor.authorBulut, Cahide
dc.contributor.authorCaksen, Huseyin
dc.date.accessioned2024-02-23T14:13:23Z
dc.date.available2024-02-23T14:13:23Z
dc.date.issued2017
dc.departmentNEÜen_US
dc.description.abstractBackground: There have been several reports of congenital malformations in the offspring of mothers who took valproic acid (VPA) during pregnancy as a treatment for epilepsy. Methods: Herein, we describe four cases with typically similar facial features of fetal vatproate syndrome accompanied to minor skeletal abnormalities. Results: The first case was a 16-month-old girl, presenting with facial dysmorphism, and finger abnormalities. Her mother took VPA (1500 mg/d) up to the 10th gestational week and at a dosage of 1000 mg/d through the pregnancy. The second patient was 5-year-old boy with speech disability, bilateral cryptorchidism, facial dysmorphism, and finger abnormalities whose mother took VPA (1000 mg/d) through pregnancy. The third 19-month-old patient was the brother of the second patient who had facial dysmorphism, bilateral cryptorchidism, and finger abnormalities. His mother also took VPA (1000 mg/d) through pregnancy. The fourth 3-year and 6 month-old boy with minor facial dysmorphism and sternum deformity was exposed to VPA (500 mg/d) in utero. Conclusion: In conclusion, there is a recognizable spectrum of abnormalities in some infants exposed to VPA without dose-depence and the common facial dysmorphic features and minor skeletal abnormalities that may occur within the both low and high dose VPA use. Copyright (C) 2016, Taiwan Pediatric Association. Published by Elsevier Taiwan LLC.en_US
dc.identifier.doi10.1016/j.pedneo.2016.01.009
dc.identifier.endpage164en_US
dc.identifier.issn1875-9572
dc.identifier.issue2en_US
dc.identifier.pmid27422007en_US
dc.identifier.scopus2-s2.0-85002713064en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage158en_US
dc.identifier.urihttps://doi.org/10.1016/j.pedneo.2016.01.009
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12423
dc.identifier.volume58en_US
dc.identifier.wosWOS:000412379500009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Taiwanen_US
dc.relation.ispartofPediatrics And Neonatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectFacial Dysmorphismen_US
dc.subjectFetal Valproate Syndromeen_US
dc.subjectMinor Birth Defectsen_US
dc.subjectSkeletal Abnormalitiesen_US
dc.titleFetal Valproate Syndromeen_US
dc.typeArticleen_US

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