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Öğe Dev Uterin Lipom(2016) Alan, Cemre; Ercan, Fedi; Balcı, OsmanSaf uterin lipom, çok nadir görülen mezenkimal benign bir neoplazmdır ve literatürde sadece birkaç olgu sunumu mevcuttur. Otuz yaş üzerindeki kadınların 20-40'ında görülen ve aynı zamanda kadınlarda en sık görülen tümör olan leiomiyomun aksine lipom, postmenopozal kadınlarda daha sıktır. Sık rastlanmayan benign neoplazmlar olan lipomatöz uterin tümörlerin insidansı 0,03- 0,2 civarındadır. Hastalar öncelikle leiomiyom tanısı almakta, son ve kesin tanıları histopatolojik inceleme sonrası konulmaktadır. Uterin duvarda görülen lipomatöz tümörlerin histopatogenezi tam olarak aydınlatılamamıştır. Yağ dokusu uterusta primer doku olmadığından bunu açıklamak için birçok teori öne sürülmüştür. Bu çalışmada, leiomiyom ön tanısı ile opere edilen ve patoloji sonucu lipom gelen 40 yaşındaki bir olgu sunulmuştur.Öğe Hearing screening outcomes in neonates of SARS-CoV-2 positive pregnant women(Elsevier Ireland Ltd, 2021) Alan, Mehmet Akif; Alan, CemreObjective: The current study aimed to investigate possible association of maternal SARS-CoV-2 with newborn hearing loss. We compared hearing screening outcomes in neonates born to women with positive SARS-CoV-2 PCR test results during pregnancy with healthy controls. Methods: Neonates born between April and December 2020 in our hospital to mothers with positive SARS-CoV-2 PCR test results during pregnancy were included in this study. Neonates with risk factors for universal newborn hearing screening (NHS) were excluded. Neonates born to mothers with positive SARS-CoV-2 PCR test results during pregnancy were compared with healthy controls in terms of newborn hearing screening results and independent variables. Results: Neonates in the COVID-19 group were more likely to have a refer result in auditory brainstem responses (ABR) compared with the control group (53/118 and 28/118, respectively; p = 0.001). The second ABR test results did not differ significantly between the groups (p = 0.618). Logistic regression revealed that birth week and type of birth were not associated with the refer result. PCR positivity in the second trimester was more likely to produce the refer result in the first ABR test (p = 0.014). Conclusion: SARS-CoV-2 PCR positivity in pregnancy is significantly associated with an increased risk of abnormal NHS results. Also, the timing of PCR positivity in pregnancy (trimester) may be related to abnormal NHS results.Öğe Long-Term Results of an Imperforate Hymen Procedure that Leaves the Hymen Intact(Springer India, 2021) Acar, Ali; Ercan, Fedi; Balci, Osman; Elci Atilgan, Adeviye; Alan, Cemre; Niftiyev, KemalPurpose of the Study The aim of this study was to show the clinical results of postoperative evaluation of cases of imperforate hymen that presented at our center during a 21-year period. Methods A Foley's catheter was inserted in 74 patients of imperforate hymen who reported to the Department of Obstetrics and Gynecology, Meram Faculty of Medicine, Necmettin Erbakan University, between January 1, 1996, and December 31, 2016 with history of pelvic pain. In each case, the hymen was opened via a circular incision from the central of the distended. A Foley's catheter was inserted, and estrogen cream was prescribed for application on the hymenal structure for 14 days. The catheter was removed after 14 days. Results The mean age of the patients at the time of this study was 28.3 +/- 2.6 years, and the mean age at diagnosis was 13.2 +/- 2.5 years. Twenty-nine (96.6%) patients had experienced vaginal bleeding during their first sexual intercourse experience, and one patient (3.4%) had not. Fourteen out of the 30 married women had become pregnant, of whom nine had delivered vaginally and five had delivered via a cesarean section. After undergoing renal ultrasound, none of the patients had any apparent anomalies. Only one patient had a uterine anomaly, which was a bicornuate uterus. Conclusion A circular incision with insertion of Foley's catheter prevents many social problems by preserving the hymen's architecture and allowing vaginal bleeding to occur during the first sexual intercourse experience.Öğe Luteal faz desteğinde östrojen: IVF-ICSI antagonist protokolde gebelik sonuçlarına etkisi(Necmettin Erbakan Üniversitesi Meram Tıp Fakültesi, 2017) Alan, Cemre; Görkemli, HüseyinBu tez çalışmasında IVF tedavisinde GnRH antagonist protokolle ovulasyon indüksiyonu yapılan hastalarda luteal fazda progesterona ek olarak verilen E2 desteğinin gebelik sonuçlarına etkisinin incelenmesi amaçlanmıştır. Yöntem: Retrospektif planlanan çalışmada hasta dosyaları taranarak GnRH antagonist protokolle ovulasyon indüksiyonu ve ICSI yapılan luteal faz desteğinde gün aşırı transdermal (7.8 mg) E2 desteği alan grup kontrol grubuyla gebelik sonuçları açısından karşılaştırılmıştır. Çalışma ve kontrol grubu 64'er kişiden oluşmaktadır. Embriyo transferinden 12 gün sonra tüm hastalara β-hCG ölçümü yapılmıştır. Sonuç negatifse tedavi kesilmiş, pozitifse estradiol kesilip progesteron desteğine gebeliğin 10. haftasına kadar devam edimiştir. Bulgular: Gruplar arasında klinik gebelik, biyokimyasal gebelik, devam eden gebelik, abortus oranları açısından anlamlı farklılık saptanmamıştır. Sonuç: Çalışmamızda GnRH antagonist protokol luteal faz desteğinde östrojen kullanımının gebelik sonuçları açısından olumlu ya da olumsuz herhangi bir etkisi izlenmemiştir. Gebelik oranları kontrol grubunda istatistiksel olarak anlamlı olmasa da çalışma grubundan daha fazladır. Bu eğilimin istatistiksel olarak anlamsız oluşu örneklemin sınırlı olmasından kaynaklanıyor olabilir. IVF'te esas başarı ölçütü canlı doğum sayısı ile ifade edilirse bunu ifade etmek için hastaların uzun dönem gebelik kaydı sonuçlarına ihtiyaç vardır. Daha objektif bir değerlendirme için daha geniş örneklemi olan, demografik özellikleri daha homojen dağılım gösteren hasta gruplarını inceleyen, canlı doğum sayılarını karşılaştıran prospektif çalışmalara ihtiyaç vardır.Öğe Maternal hypertension, pre-eclampsia, eclampsia and newborn hearing: A retrospective analysis of 454 newborns(Elsevier Ireland Ltd, 2021) Alan, Cemre; Alan, Mehmet AkifObjective: Maternal hypertension and preeclampsia have been related to sensorineural hearing loss in newborns. To investigate potential connections, we compared newborn hearing screening (NHS) results from newborns of mothers with chronic hypertension, preeclampsia, and eclampsia with results from newborns of healthy controls. The present study is unique with regard to its large sample size and the analysis of the possible effects of three different hypertensive disorders on newborn hearing. Methods: We retrospectively searched the database of our hospital for pregnant women diagnosed with chronic hypertension, preeclampsia, and eclampsia according to the International Classification of Diseases Tenth Revision (ICD-10) diagnostic codes. The search covered the period from January 2010 to March 2020. NHS results were compared with those of newborns of healthy controls. Results: The auditory brainstem response (ABR) test results and categorical variables of infants of 146 women with preeclampsia, 71 women with chronic hypertension, and 10 women with eclampsia were compared with those of infants of 227 healthy women. Only the bilateral pass results were statistically significantly lower in the preeclampsia group in comparison to the control group (p = 0.036), but this was a temporary effect. Between the two groups, there was no significant difference in the second ABR (ABR refer) test. Conclusion: There was a statistically significant difference between the preeclampsia and control groups only in the first ABR test. But, the ABR refer test results of these groups did not differ significantly. Therefore, we conclude that these temporary effects may be related to newborns being born prematurely and being small for their gestational age.
