Yazar "Calik, Mustafa" seçeneğine göre listele
Listeleniyor 1 - 10 / 10
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe The effect of costal cartilage resection on the chest wall development: Pathological evaluation(European Respiratory Soc Journals Ltd, 2015) Calik, Mustafa; Calik, Saniye Goknil; Avunduk, Mustafa Cihat; Aribas, Olgun Kadir[Abstract Not Availabe]Öğe The effect of Halofuginone in the amelioration of radiation induced-lung fibrosis(Churchill Livingstone, 2013) Yavas, Guler; Calik, Mustafa; Calik, Goknil; Yavas, Cagdas; Ata, Ozlem; Esme, HidirThe lung is one of the most sensitive organs to ionizing radiation, and damage to normal lung tissue remains a major dose limiting factor for patients receiving radiation to the thorax. Radiation induced lung injury (RILI) which is also named as radiation pneumonpathy is a continuous process and regarded as the result of an abnormal healing response. It has been shown that transforming growth factor beta-1 (TGF-beta 1) plays an integral role in the radiation induced lung fibrosis formation by promoting the chemoattraction of fibroblasts and their conversion to myofibroblasts. Halofuginone is a, low molecular weight plant derived alkaloid, isolated from the Dichroa febnfuga plant that exhibits antifibrotic activity and inhibition of type I collagen synthesis. Halofuginone has been shown to protect against radiation induced soft tissue fibrosis by virtue of inhibiting various members of TFG-beta signaling pathway. By the light of these findings, we hypothesize that Halofuginone may be able to ameliorate the radiation induced lung fibrosis. (C) 2013 Elsevier Ltd. All rights reserved.Öğe The effect of low-intensity pulsed ultrasound on rib fracture: An experimental study(Baycinar Medical Publ-Baycinar Tibbi Yayincilik, 2020) Calik, Saniye Goknil; Calik, Mustafa; Kasdogan, Zumrut Ela Arslan; Yilmaz, Halim; Karaca, Gulten; Akkurt, Halil Ekrem; Esen, Haci HasanBackground: In this study, we aimed to investigate the effects of low-intensity pulsed ultrasound on rib fracture healing in a rat model. Methods: A total of 72 male Wistar-Albino rats were randomly divided into three equal groups. To induce a rib fracture, right thoracotomy was performed under general anesthesia and a 0.5-cm segment was removed from the fourth and fifth ribs. After 24 h of surgery, low-intensity pulsed ultrasound was implemented according to the groups. Group 1 served as the control group for the observation of normal bone healing. Low-intensity pulsed ultrasound was applied at a dose of 20% (2 msn pulse-8 msn pause) 100 mW/cm(2) and 50% (5 msn pulse-5 msn pause) 200 mW/cm(2) for six min, respectively in Group 2 and Group 3. All subjects were followed for six weeks. Eight animals from each group were sacrificed at two, four, and six weeks for further assessment. Histological alterations in the bone were examined. Results: Although there was no statistically significant difference in osteoblasts, osteoclasts, new bone formation, and lymphocyte count among the groups, histological consolidation was significantly increased by low-intensity pulsed ultrasound. While low-intensity pulsed ultrasound induced osteoblastic, osteoclastic, and new bone formation, it inhibited lymphocyte infiltration. Conclusion: Low-intensity pulsed ultrasound, either at low or high doses, induced the histological consolidation of rib fractures and inhibited lymphocyte infiltration. This effect was more prominent in the long-term and at higher dose with increased daily and total administration time. We, therefore, believe that accelerating the natural healing process in patients with rib fractures would enable to treat more effectively in short-term.Öğe The Effects of Low Dose Zinc Supplementation on the Development of New Bone in Rabbits(Istanbul Training & Research Hospital, 2020) Calik, Mustafa; Calik, Saniye Goknil; Dagli, Mustafa; Avunduk, Mustafa CihatIntroduction: Zinc (Zn) is an essential element for the healthy bone metabolism. It promotes bone formation by stimulating the proliferation and differentiation of osteoblasts, and increases the stimulation of osteoblastic bone mineralisation. Also, it suppresses the differentiation of osteoclasts while inhibiting bone resorption. The purpose of this study is to investigate the effects of low-dose Zn supplementation on new bones grown in rabbits. Methods: We evaluated 40 male white rabbits aged six weeks from New Zealand in 8 groups, with each including 5 subjects. All the groups underwent subperichondrial costal cartilage resections from the third rib on the right hemithorax. Rabbits in first and second groups underwent the partial resection of two ribs, and rabbits in third and fourth groups underwent total rib resection. Rabbits in fifth and sixth groups underwent the partial resection of four ribs, whereas rabbits in seventh and eighth groups underwent total resection. Rabbits in Groups 2, 4, 6, and 8 were treated with 6 mg/kg/day intraperitoneal Zn for four weeks after the operation. All groups were followed up to the 24th week of their lives. Results: We detected a statistically significant difference for both osteoblasts and osteoclasts among all the subgroups. Additionally, we also detected a significant increase in bone consolidation by Zn supplementation. Our study found that Zn suppresses osteoblastic bone absorption by stimulating osteoblastic bone formation in the light of the literature. Conclusion: Low-dose Zn administration in rabbits has been found to expedite the rib consolidation. Zn can be used to increase the bone maturation such as at the site of new bone formation in rib fracture and after all kinds of operations related to bones.Öğe Effects of topical mitomycin-C on the tracheal epithelia of rabbits following tracheostomy(Tubitak Scientific & Technological Research Council Turkey, 2021) Calik, Saniye Goknil; Calik, Mustafa; Kasdogan, Zumrut Ela Arslan; Avunduk, Mustafa Cihat; Aribas, Olgun Kadir; Esme, HidirBackground/aim: We aimed to investigate the topical application of mitomycin-C (MMC) after the conventional tracheostomy in a rabbit model. Materials and methods: Twenty-four male New Zealand White rabbits were randomly divided among 3 equal groups (n: 8). Tracheostomies were performed on 16 subjects. Group 1 which served as a control for all tracheal measurements. After tracheostomy, we applied sterile saline (group 2) or MMC at 0.8 mg/mL (group 3) around the tracheotomy site for 5 min. At the 3rd week after surgery, all tracheas were subjected to morphometric and histopathological examinations, including tracheal lumen diameter (LD), number of capillary vessels (CV), subepithelial tissue thickness (SETT), fibroblasts, and inflammatory cells (IC). Results: There was a statistically significant difference between the two tracheostomy groups themselves and the control group for LD (p = 0.035), CV (p = 0.006), SETT, fibroblasts, and IC (p < 0.001). Histopathological analysis showed the decreased LD, CV, SETT, IC, and fibroblasts compared to MMC with tracheostomy groups. MMC was more effective than saline for LD, CV, SETT, IC, and fibroblasts. Conclusion: Wound healing modulation may prevent scar formation. Fibrosis decreased following tracheostomy in the group treated with MMC. Fibroblasts appear to be key cells mediating these effects.Öğe How successful is pleural sound sign in the identification of pneumothorax?(Kare Publ, 2019) Calik, Saniye Goknil; Calik, Mustafa; Girisgin, Sadik; Karaoglan, Osman; Dundar, Zerrin Defne; Ergin, MehmetOBJECTIVE: In the present study, in thorax ultrasonography (USG) Doppler images obtained from cases with occult pneumothorax, we investigated the status of pulsatile pleural sounds over the pleural line and called these as the pleural sound sign (PSS). The purpose of the present study was to identify the efficacy of the proposed PSS in diagnosing pneumothorax and to compare it with the other USG findings including the sliding lung sign (SLS) and seashore sign (SSS). METHODS: The present study included 66 consecutive patients who were referred to the emergency unit with a blunt trauma from October 2009 to January 2010 at a tertiary university hospital. RESULTS: Of the 66 patients, 34 were in the patient group, and 32 were in the control group. Males accounted for 66.7% (n=44) of the study population. In predicting pneumothorax, the areas under receiver operating characteristic (ROC) curves of PSSmax and PSSdifference were 0.989 and 0.990, respectively. While the sensitivity of the SLS was 88% and the sensitivity of the SSS was 56%, the specificities of the SLS and SSS were 100%. Based on our findings, accuracy ranking was as follows: PSSmax = PSSdifference > SLS > SSS. CONCLUSION: New applications of thorax USG are rapidly growing. Our findings have to be confirmed in a large patient series. PSS is not a novel method, but it enhanced the importance of USG in the diagnosis of pneumothorax. We can stipulate that it can replace thorax computed tomography imaging particularly for the diagnosis of occult pneumothoraxes.Öğe How successful is pleural sound sign in the identification of pneumothorax?(Kare Publ, 2019) Calik, Saniye Goknil; Calik, Mustafa; Girisgin, Sadik; Karaoglan, Osman; Dundar, Zerrin Defne; Ergin, MehmetOBJECTIVE: In the present study, in thorax ultrasonography (USG) Doppler images obtained from cases with occult pneumothorax, we investigated the status of pulsatile pleural sounds over the pleural line and called these as the pleural sound sign (PSS). The purpose of the present study was to identify the efficacy of the proposed PSS in diagnosing pneumothorax and to compare it with the other USG findings including the sliding lung sign (SLS) and seashore sign (SSS). METHODS: The present study included 66 consecutive patients who were referred to the emergency unit with a blunt trauma from October 2009 to January 2010 at a tertiary university hospital. RESULTS: Of the 66 patients, 34 were in the patient group, and 32 were in the control group. Males accounted for 66.7% (n=44) of the study population. In predicting pneumothorax, the areas under receiver operating characteristic (ROC) curves of PSSmax and PSSdifference were 0.989 and 0.990, respectively. While the sensitivity of the SLS was 88% and the sensitivity of the SSS was 56%, the specificities of the SLS and SSS were 100%. Based on our findings, accuracy ranking was as follows: PSSmax = PSSdifference > SLS > SSS. CONCLUSION: New applications of thorax USG are rapidly growing. Our findings have to be confirmed in a large patient series. PSS is not a novel method, but it enhanced the importance of USG in the diagnosis of pneumothorax. We can stipulate that it can replace thorax computed tomography imaging particularly for the diagnosis of occult pneumothoraxes.Öğe Prognostic factors in mechanically ventilated patients(Bayrakol Medical Publisher, 2020) Calik, Saniye Goknil; Calik, Mustafa; Cander, BasarAim: In this study, we aimed to investigate the prognostic values of respiratory parameters recorded within the first 48 hours in patients connected to mechanical ventilation in the intensive care unit (ICU), in terms of 30-day mortality. Material and Method: This prospective study included patients who received mechanical ventilation due to acute respiratory failure between 2011 and 2013. The demographic characteristics of the patients, Glasgow Coma Score (GCS) scores, Acute Physiology and Chronic Health Evaluation II (APACHE II) and Sequential Organ Failure Assessment (SOFA) values, vital signs, the results of complete blood count, biochemistry parameters and blood gas analyses were recorded. Patients were divided into two groups as survivors and non-survivors, and the differences in the parameters between the groups were analysed. Results: The study included 99 mechanically ventilated patients with the mean age 71.73 (18-105) years. Of the patients, 56 (56.6%) were male and 43 (43.4%) were female. Comparison of the survivors (n=37) with the non-survivors (n=62) indicated that the non-survivors had no statistical differences in terms of age, gender, or concomitant diseases. The values of GCS, APACHE II, and SOFA were significantly different between survivors and non-survivors (for all, p<0.001). Significant differences were also noted in FiO2 (p<0.001), pH (p=0.001), PO2 (p=0.044), PCO2 (p=0.046), A-a Gradient (p<0.001) and the expected increase of O2 gradient (p=0.026) between two groups. Discussion: Our findings indicate that, during the follow-up of the mechanically ventilated patients, respiratory parameters measured within the first 48 hours are cheap and easy-to-use parameters to predict the prognosis.Öğe Rib fractures: Could we accelerate the healing?(Bayrakol Medical Publisher, 2020) Calik, Mustafa; Calik, Saniye Goknil; Dagli, Mustafa; Avunduk, Mustafa CihatAim: We thought about How fractures are improving more rapidly. For this purpose, we made an experimental model to investigate the effect of zinc supplementation on the development of new bone in young rabbits. Material and Method: Six weeks of age, male New Zealand white rabbits were evaluated in four groups, each including five subjects. To simulate the RFs, subperichondrial costal cartilage resections beginning from the third costal cartilage were carried out in the right hemithorax according to groups. Rabbits in Group 1 and 2 underwent partial resection of the two ribs; rabbits in Group 3 and 4 underwent total resection of those. Zinc was administered by intraperitoneal injection of 6 mg/kg/ day for four weeks after the surgery for group 2 and 4. The animals were followed-up at the twenty-fourth week of their life. Results: We analyzed histologic changes in the bone. There were statistically significant differences for osteoblasts and osteoclasts among all subgroups. Histologic consolidation was significantly increased by zinc supplementation. According to the literature, in our study, while zinc stimulates osteoblastic bone formation, suppresses osteoclastic bone resorption. Discussion: Although the proper treatment of rib fracture (RF), long-term disability and persistent chest wall pain frequently develop and may take several months to recover, leads to the high hospital, medicine, labor, and social burden. Our findings indicate that zinc supplementation accelerates the consolidation of ribs. Zinc can be used to increase the bone maturation such as the site of new bone formation in RF.Öğe Tracheostomy, is it really innocent?(European Respiratory Soc Journals Ltd, 2015) Calik, Mustafa; Calik, Saniye Goknil; Avunduk, Mustafa Cihat; Aribas, Olgun Kadir[Abstract Not Availabe]
