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Öğe Cerebellitis and Concomitant Acute Hydrocephalus in a Child: Case Report(2014) Erdi, Fatih; Emiroğlu, Melike; Kaya, Bülent; Karataş, Yaşar; Güney, ÖnderAcute cerebellitis is a severe neurological disease characterized by mild or high-grade fever, nystagmus, tremor, truncal ataxia, dysarthria, headache, and altered mental state. The diagnose can be established on the basis of clinical symptoms, radiological imaging and laboratory findings. Acute life threatening hydrocephalus can be seen as a complication of acute cerebellitis associated with obstruction at the level of the fourth ventricle. Neurosurgical procedures as a life-saving intervention can be required which range from external ventricular drainage to ventricular peritoneal shunt and posterior fossa decompression. In this report we present a case of cerebellitis and concomitant acute hydrocephalus in a child which was treated succesfully with external ventricular drainage and medical treatment and also discuss the main features of this rare but important concomitance.Öğe Effect of Carvedilol on Secondary Damage in Experimental Spinal Cord Injury in Rats(2015) Karataş, Yaşar; Cengiz, Şahika Liva; Esen, Hacı Hasan; Toker, Aysun; Savaş, ÇiğdemAim: Previous studies have shown that carvedilol has a neuroprotective effect in animal models of brain ischemia and brain oxidative damage in vitro. This study was perfomed to investigate the effect of carvedilol on the secondary damage in experimental spinal cord injury (SCI). Material and methods: Twenty-four Wistar albino rats were divided into three groups. Group 1 underwent laminectomy alone. Group 2 underwent laminectomy followed by SCI and received carvedilol. Group 3 underwent laminectomy followed by SCI and received no medication. The neurological functions were assessed by Tarlov’s motor scale at the first and 24th hours. Oxidative stress status was assessed by MDA, SOD, MPO, GSH activities. A TUNEL-based apoptosis kit was used for evaluating apoptosis in the spinal cord samples and hematoxylinand eosin-stained specimens were used for light microscopic examination. Results: Carvedilol reduced apoptosis and regulated oxidant and antioxidant status by increasing SOD and GSH levels and reducing MPO and MDA levels in the spinal tissue homogenate. Neurological examination of rats revealed statistically significant improvement 24 hours after the trauma. Conclusion: Carvedilol has a statistically significant therapeutic effect, especially on functional recovery, and we found that carvedilol reduced secondary damage by inhibiting apoptosis and regulating the oxidant and antioxidant status.Öğe Isolated Dural and Calvarial Metastasis in a patient with Breast Carcinoma: A Case Report(2015) Kaya, Bülent; Erdi, Fatih; Keskin, Mehmet Fatih; Karataş, Yaşar; İzci, Emir Kaan; Toğuşlu, GökhanLiteratürde malign neoplazmların dural metastazları ile ilgili az bilgi bulunmaktadır. Kesin etyopatogenezleri ve tedavi stratejileri tartışmalıdır. Dura matere en sık metastaz meme kanserinden olmaktadır. 41 yaşında bayan hasta kliniğimize baş ağrısı ve sol parietalde şişlik şikayeti ile başvurdu. Hasta 3 yıl önce infiltratif duktal kanser nedeni ile opere edilmişti. Sol kalvaryal ve dura metastazı tespit edildi ve sol pariyetal kraniotomi ile cerrahi rezeksiyon uygulandı. Hasta operasyondan sonra tüm beyin radyoterapi aldı. Bu yazıda kafatası ve duraya metastaz yapan bir kanser vakasını ve bu nadir hastalığın ana özelliklerini tartıştık.Öğe Multiple Lumbar Perineural Cysts Presented with Nonspecific Back Pain(2013) Kaya, Bülent; Kalkan, Erdal; Erdi, Fatih; Keskin, Fatih; Karataş, YaşarBu yazıda oldukça nadir görülen çoklu lomber perinöral kist olgusu sunulmuştur. Talov kistleri olarak da bilinen perinöral kistler genellikle sakral bölge yerleşimlidirler. Çoklu lomber perinöral kistler oldukça nadir görülürler. 50 yaşındaki erkek hasta nonspesifik bel ağrısı şikayeti ile kliniğimize başvurdu.Nörolojik muayenesi normal sınırlarda idi. Manyetik rezonans görüntülemede lomber bölgede multipl perinöral kist saptandı. Hastaya herhangi bir cerrahi müdahale olmadan tıbbi tedavi uygulandı. Hasta medikal tedaviden oldukça yarar gördü. Multipl lomber perinöral kistlerin nörolojik bulgu vermeden görülmeleri oldukça nadir olmasına rağmen tedavi stratejileri konusunda tartışmalar devam etmektedir.Öğe New Clues in the Malignant Progression of Glioblastoma: Can the Thioredoxin System Play a Role?(2018) Erdi, Fatih; Kaya, Bülent; Esen, Hasan; Karataş, Yaşar; Fındık, Sıddıka; Keskin, Fatih; Feyzioğlu, Bahadır; Kalkan, ErdalAIm: To evaluate and compare the expression of thioredoxin reductase 1 (TrxR1) in primary and secondary glioblastoma samples. mATERIAl and mEThODS: Surgically resected human glioblastoma samples from 40 patients who underwent surgery at our institution were extracted from their histopathological specimens and divided into three groups. Ten histopathologically regular cerebral tissue samples, acquired from the non-neoplastic portion of the specimens, were assigned as the control group. Twenty specimens that included tumoral tissue from each type of glioblastoma (WHO grade IV, primary and secondary) were assigned as the primary and secondary glioblastoma groups. TrxR1 expression was analyzed by using both quantitative reverse transcription polymerase chain reaction (qRT-PCR) and immunohistochemistry. Isocitrate dehydrogenase 1 (IDH1) mutation was analyzed by immunohistochemistry. Ki-67 proliferative index and apoptosis were also analyzed by immunohistochemistry. The differences between the groups were statistically compared and the correlation between these parameters was analyzed. RESulTS: The expressions of TrxR1 and Ki-67 values were significantly higher in primary glioblastoma. IDH1 mutation was significantly higher in secondary glioblastoma. TrxR1 expression was found to be highly correlated with the Ki-67 index. The apoptotic index was similar between primary and secondary glioblastoma. CONCluSION: This study showed a high TrxR1 expression in primary glioblastoma which could indicate a role of the Trx system in promoting the malignant progression by some complex processes.Öğe Supratentoryal ve infratentoryal yerleşimli multiple kavernom olgusu(2013) Kalkan, Erdal; Keskin, Fatih; Karataş, Yaşar; Kaya, Bülent; Güney, Ahmed ÖnderSerebral kavernöz hemanjiomlar vasküler yapıların nadir görülen malformasyonlarındandır. Sporadik formda lezyonlar genellikle tek iken, lezyonların multipl olması daha çok familyal tipte rastlanılan bir durumdur. Semptomatik hastalar başağrısı, epileptik nöbet, fokal nörolojik defisit, hemoraji veya bunların kombinasyonu ile hastaneye başvururlar. Bizim olgumuz multiple supratentoryal lezyonların yanı sıra infratentoryal tutulumun da birlikte görülmesi ve multiple kavernom olmasına rağmen herediter geçişli olmaması nedeniyle literatürdeki sunumlardan farklılık göstermektedir.
