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Öğe Associations Between Nucleus Size, and Immunohistochemical Galectin-3, Cytokeratine-19 and Hbme-1 Markers in Thyroid Papillary Carcinoma: A Morphometric Analyze(Springer, 2019) Toy, Hatice; Etli, Ozlem; Celik, Zeliha Esin; Alikanoglu, Arsenal SezginThis study aimed to evaluate the morphometric measurements in cases with papillary thyroid carcinoma, and determine a cut-off value to support diagnosis. Fifty cases with a diagnosis of papillary thyroid carcinoma (PTC) were included in the study with their Galectine-3, CK-19 and HBME-1 immunohistochemical staining results. Demographic and clinical data gathered from pathology reports, which included demographic information such as patients' sex, age, macroscopic tumor size, number of tumor focuses; prognostic parameters such as lenfovascular invasion, perineural invasion, thyroid capsule invasion; and results of immunohistochemical CK- 19, Galectin-3 and HBME-1 staining. Longest nuclear diameters of 150 tumor cells and 150 normal thyrocytes of each case were manually measured in an image analysis software, and mean longest nuclear diameters (MLND-TC and MLND-NC), and also tumor cell/normal cell longest nuclear diameter ratio (TC/NC-LNDR) were calculated. MLND-TC was higher than MLND-NC. The cases with higher MLND-TC had increased risk of capsule invasion in case of a negative staining with Galectine-3, HBME-1, or CK-19. When TC/NC-LNDR was high, number of tumor focus tended to be multiple and lymphovascular invasion risk was also increased. Subtypes of PTC were not differed regarding staining patterns. And finally, increased TC/NC-LNDR was associated with increased risk of having poor prognostic factors. The results of this study suggest that MLND-NC, MLND-TC, and TC/NCLNDR are valuable and easy-to-use measures, which can assist routine histology practice.Öğe Benign cephalic histiocytosis(Medknow Publications & Media Pvt Ltd, 2013) Daye, Munise; Dogan, Seda; Mevlitoglu, Inci; Toy, Hatice[Abstract Not Availabe]Öğe Bir çocukta serebellumun disembriyoplastik nöroepiteliyal tümörü(2014) Köse, Doğan; Kalkan, Erdal; Paksoy, Yahya; Toy, Hatice; Üçüncü Ergün, Nurcan; Köksal, YavuzDisembriyoplastik nöroepitelyial tümörler (DNT) tipik olarak supratentorial yerleşen benign neoplazmalardır. Bilinç ve postural tonus kaybı şikayetleri ile bir lokal hastaneye başvuran 12 yaşındaki erkek hasta saptanan serebellar kitlesi nedeniyle hastanemize refere edildi. Hikayesinden benzer şikayetlerinin 3 ve 10 yaşlarında da tekrar ettiği ancak o dönemde pediatric kardiyolog ve pediatric nörolog tarafından yapılan incelemelerde herhangi bir anomaliye rastlanmadığı öğrenildi. Hastanın fizik muayenesi ve rutin laboratuvar tetkikleri normaldi. Serebellumda saptanan kitle total olarak çıkarıldı. Alınan dokunun histopatolojik değerlendirmesi ile hastaya DNT tanısı konuldu. Hasta halen, 5 yıldır, herhangi bir nüks belirtisi olmadan ayaktan takip edilmektedir. Bu yazıda serebellum yerleşimli DNT'ye sahip bir çocuk vakanın literatürle paylaşılması amaçlanmıştır.Öğe A case report of primary tuberculosis of the tongue(Modestum Ltd, 2017) Korkmaz, Celalettin; Daye, Munise; Teke, Turgut; Toy, Hatice; Hasal, Eda; Yavsan, Durdu MehmetAt present, the rate of extrapulmonary tuberculosis is gradually increasing among all tuberculosis cases. The secondary tuberculosis of oral cavity represents 0.2-1.5% of all cases with extrapulmonary tuberculosis. Although incidence of oral lesions secondary to pulmonary tuberculosis ranges from 0.4% to 1.5%, primary tuberculosis of the tongue occurs very rare, and it is published only as isolated case reports. A male patient presented to our dermatology clinic with complaints of painful ulcerated white plaques on the tip of his tongue lasting for three months, and an excisional biopsy showed granulomatous inflammation with caseification necrosis. Pulmonary and systemic examination showed no evidence of pulmonary or other extra-pulmonary tuberculosis, and he was initiated therapy for diagnosis of primary tuberculosis of the tongue. We found that the lesion completely resolved during the follow up visit after 1 month. Primary tuberculosis of the tongue should be for differential diagnosis of resistant painful oral lesions.Öğe Coexistence of Glomangioma and Yolk Sac Tumour in a Child: A Case Report(Premchand Shantidevi Research Foundation, 2014) Kose, Dogan; Toy, Hatice; Gunel, Engin; CaliSkan, Umran; Koksal, YavuzGlomus tumours (GTs) primarily arise from glomus bodies that are located in the dermis layer of skin. However, they can be encountered ectopically in most parts of the body. As a result of researches done in a 17-month-old male patient who prssented to us with complaint of an increasingly growing swelling, he was diagnosed with a yolk sac tumour. Chemotherapy was started and then, he was operated. GT was found inside the tumoural mass. Our patient, who is the first case according to our knowledge, where the concurrence of yolk sac and glomus tumours was reported, has been discussed in the light of literature.Öğe Comparison of Bone Dust With Other Types of Bone Grafts for Cranioplasty(Lippincott Williams & Wilkins, 2014) Karamese, Mehtap; Toksoz, Mustafa Rasid; Selimoglu, Muhammed Nebil; Akdag, Osman; Toy, Hatice; Tosun, ZekeriyaPurpose: Split calvarial bone graft is preferred in the reconstruction of calvarial defects. However, it is not feasible for use in some challenging cases and in children. Particulate bone graft containing viable osteoblasts could be an attractive alternative. Materials and Methods: A total of 32 female rats were randomly separated into 4 groups. Full-thickness bone graft from rat calvaria was harvested in diameters of 8 x 8 mm. In group 1, the periosteum and skin were closed without any bone graft; bone dust particles were placed in group 2; bone fragments were placed in group 3; and full-thickness cranial bone graft was placed in group 4. After 12 weeks, all rats were killed. Degrees of resorption, foreign body reaction, and bone spicule length were assessed histologically, and an immunohistochemical study was used to show bone graft viability. Results: In graft viability, osteogenesis, and osteoblastic differentiation, groups 3 and 4 were similar and superior to groups 1 and 2. No osteoblastic activity and no viable bone dust were detected in groups 1 and 2. Resorption was observed in every preparate that contains bone tissue, and foreign body reaction was prominent in small bone groups, such as in group 2. Conclusions: In the full-thickness cranial bone graft group and the bone fragment group, the preservation of bone viability was obviously superior to the bone dust group and the periosteum-only group. In conclusion, bone dust behaved like the periosteum and could not create new bone, whereas bone particles behaved like the full-thickness cranial bone graft and were capable of preserving viability.Öğe Complete response and long-term remission to anti-HER2 combined therapy in a patient with breast cancer presented with bone marrow metastases(Sage Publications Ltd, 2014) Artac, Mehmet; Koral, Lokman; Toy, Hatice; Guler, Tunc; Boruban, Melih C.; Altundag, KadriPresentation with bone marrow metastasis at diagnosis is a rare event in breast carcinoma. Here, we report a rare presentation of metastatic breast cancer patient with bone marrow metastases, who was successfully treated with trastuzumab combined chemotherapy. The regimens initially applied for bone marrow metastasis were docetaxel/adriamycin, gemcitabine/vinorelbine, epirubicin/cyclophosphamide, capecitabine, docetaxel, gemcitabine, and paclitaxel. But, the best response to these regimens was not satisfactory. Our patient was completely treated with etoposide-cisplatin and trastuzumab combination. She is still on remission after five years of metastatic breast cancer diagnosis using letrozole and trastuzumab without complication. Physicians should be careful in treating bone marrow metastases in breast cancer, since patients can show improved marrow function after chemotherapy and long-lasting survival is possible.Öğe Course of sepsis in rats with thyroid dysfunction(2017) Taşcı, Halil İbrahim; Erikoğlu, Mehmet; Toy, Hatice; Karaibrahimoğlu, AdnanObjective: Numerous studies show the relationship between sepsis and thyroid hormones. Virtually all these studies investigate changes in post-sepsis thyroid hormones and the relationship between these changes and the progression of the disease. Our aim in this study was to investigate the progression of sepsis in rats with thyroid dysfunction. Material and Methods: The study involved four groups, each containing seven female Wistar albino rats: Group 1: Sham, Group 2: Control (Sepsis), Group 3: Hyperthyroidism-Sepsis, and Group 4: Hypothyroidism-Sepsis. Group 1 only received laparotomy. Group 2 only had sepsis. Sepsis was induced in Group 3 and Group 4 following formation of hyperthyroidism and hypothyroidism, respectively. After 24 hours, relaparotomy and thoracotomy were performed, and tissue and blood samples were drawn. Results: Dysfunctions seen in the liver, lungs, and kidneys during sepsis and other findings of sepsis were milder in the hyperthyroidism group in comparison to both the control and hypothyroidism groups. Conclusion: The results of Simon’s grade, histopathological organ damage, and laboratory parameters revealed that the progression of sepsis was milder in the hyperthyroid group than in the hypothyroid and euthyroid groups. The progression in the hypothyroid group was the most severe. Therefore, the results of the study raise the question of whether immediate treatment in cases of hypothyroidism and slow return of thyroid function to normal levels in cases of hyperthyroidism are adequate treatment approaches in patients who may develop sepsis or septic shock.” To determine the answer to this question, more detailed studies are required with a higher number of subjects.Öğe THE EFFECT OF ADIPOSE TISSUE STROMAL VASCULAR FRACTION COMBINED WITH PLATELET-RICH PLASMA ON IRRADIATION-INDUCED CAPSULAR CONTRACTURE AROUND SILICONE IMPLANTS(Medknow Publications & Media Pvt Ltd, 2014) Gundeslioglu, Ayse Ozlem; Inan, Irfan; Tezcan, Yilmaz; Toy, Hatice; Emlik, Dilek; Aktan, Murad; Duman, SelcukThe exact reason and pathogenesis of capsule formation around breast implant after cosmetic and reconstructive breast enhancement is still unclear. However, recent studies and clinical observations regarding the application of adipose-derived mesenchymal stem cells around implanted biomaterials have shown encouraging results. In this study, the effects of the adipose-derived stromal vascular fraction combined with platelet-rich plasma on capsule formation around silicone implants were investigated in irradiated rats. After implantation of silicones implants bilaterally on the rat dorsal area, both sides were irradiated with 10-Gy as single fraction electron beam irradiation. Following radiation, the mixture of stromal vascular fraction and platelet-rich plasma was injected to right sides of the animals. Left sides were injected with same amount of saline as a control. On day 30, capsule around the implants was evaluated in regarding the capsular thickness by ultrasonography, histopathology and immunohistochemical examination. The results demonstrated that there is no statistically significant difference between the treated and non-treated groups in ultrasonographic, histopathologic, and immunohistochemical evaluations. These preliminary results demonstrated that adipose-derived stem cells with platelet rich plasma do not have efficiency for integration of tissue and silicone implants and to reduce capsule formation and further studies are requiredÖğe The Effect of Zinc Deficiency and Supplementation on Elements in the Kidney Tissue of Ovariectomized Rats: Histopathologic Changes(Verlag Hans Huber, 2017) Baltaci, Abdulkerim Kasim; Sunar, Fusun; Mogulkoc, Rasim; Toy, HaticeThe objective of the present study is to determine the effects of zinc deficiency in and zinc supplementation to ovariectomized rats on some elements in kidney tissue. The study included 40 Sprague-Dawley type adult female rats. The experimental animals were randomized into four groups with equal numbers as follows: Group 1: Control (10). Group 2: Ovariectomized control (10). Group 3: Ovariectomized + zinc supplemented (10). Group 4: Ovariectomized + zinc deficient (10). After the animals were decapitated at the end of the experiment, element levels were determined by Atomic Emission (ICP-AES) as mg/g/wet tissue for calcium, phosphate, zinc, aluminum, copper, iron, lithium, and manganese and mu g/g/wet tissue for magnesium in the kidney tissue. Additionally, the tissue samples were subjected to a histopathologic assessment. An examination of the study results showed that ovariectomy significantly reduced calcium, phosphorus, and zinc levels, while zinc supplementation to the rats following ovariectomy restored the reduced element levels to normal (0.10 +/- 0.03, 0.85 +/- 0.16, 0.11 +/- 0.03 vs 0.19 +/- 0.06, 1.86 +/- 0.18, 0.52 +/- 0.05). Group 4, which was both ovariectomized and fed on a zinc-deficient diet, had significantly lower aluminum, copper, and lithium values. Calcification, inflammation, and sclerotic changes in group 4, the group which was fed on a zinc-deficient diet, were greater in comparison to other groups (p < 0.05). Results of the study suggest that ovariectomy + zinc deficiency leads to calcification, inflammation, and sclerotic changes in renal tissue and significantly reduces element levels, whereas zinc supplementation after ovariectomy restores the lowered element levels to normal.Öğe The effect of zinc deficiency and zinc supplementation on element levels in the bone tissue of ovariectomized rats: Histopathologic changes(Taylor & Francis Ltd, 2014) Baltaci, Abdulkerim Kasim; Sunar, Fusun; Mogulkoc, Rasim; Acar, Musa; Toy, HaticeObjective: Study aimed to determine the effects of zinc supplementation/deficiency on the histological structure and elements levels in bone tissue in ovariectomized rats. Methods: The study included 40 Sprague-Dawley type adult female rats, divided as follows: Control, ovariectomized, ovariectomized + zinc supplemented, ovariectomized + zinc deficient groups. At the end of the study bone tissues (femur) were collected to determine the levels of calcium, phosphorus, magnesium, zinc, iron, aluminium, chrome, lithium, lead, nickel, and manganese. The bone tissue was examined for histopathology. Results: Ovariectomy leaded to significant decrease in magnesium. Zinc supplementation to ovariectomized rats restored the reduced calcium, phosphorus, zinc. However, zinc deficiency in ovariectomized rats further reduced calcium, phosphorus, zinc, and manganese levels. Zinc deficiency in ovariectomized significantly increased Al, Cr, Li, Pb, and Ni levels. Tissue integrity was impaired due to ovariectomy and zinc deficiency. Conclusion: Ovariectomy and zinc deficiency leads significant decreases elements of the bone.Öğe The effects of botulinum toxin A and papaverine on human saphenous vein and internal mammary artery grafts: an in vitro study(Termedia Publishing House Ltd, 2022) Duman, Ipek; Tanyeli, Omer; Dereli, Yuksel; Oltulu, Pembe; Toy, Hatice; Sahin, Ayse SaideIntroduction: Autologous saphenous vein (SV) and internal mammary ar-tery (IMA) are used as bypass conduits during coronary artery bypass graft surgery. Vasospasm of the arterial and venous grafts may constitute a sig-nificant clinical problem. Pretreatment with a vasodilator drug of the graft ex vivo or intraluminal injection before implantation may be used for spasm prophylaxis. This in vitro study was designed to assess the vasoactive ef-fects and time-dependent changes of botulinum toxin A (BTX-A) and pa-paverine pretreatment on vasospasm of human SV and IMA grafts. Also, histomorphology of the vessels was assessed.Material and methods: SV and IMA segments were suspended in organ baths, and isometric contraction responses to 2 different concentrations of 5-hydroxytryptamine (5-HT) and endothelin-1 (ET-1) were recorded after in-cubation with 2 different concentrations of BTX-A and papaverine at 2 time points (0 h and 2 h).Results: The results revealed the following: 1) incubation with BTX-A and papaverine relaxes both SV and IMA rings contracted with 5-HT and ET-1; 2) the duration of the relaxant effect of BTX-A lasts longer than papaverine; and 3) no apparent histomorphological changes were observed in the grafts under light microscopy.Conclusions: This study demonstrates that in human SV and IMA grafts, pretreatment with both BTX-A and papaverine are safe and have a potent inhibitory effect depending on the vessel and vasoconstrictor agent. The long-lasting vasodilatory effect of BTX-A on vascular smooth muscle may provide promising results in the prevention of venous and arterial graft spasm.Öğe The Effects of Electrocautery on Peripheral Nerve: An Experimental Study(Thieme Medical Publ Inc, 2016) Karalezli, Nazim; Koktekir, Ender; Yildirim, Serhat; Toy, Hatice; Oz, Mehmet; Yuceturk, AydinBackground The aim of this study was to assess the usability of an electrocautery device as nerve stimulator and to investigate histopathologically the adverse effects of electrocautery at low power on rat sciatic nerves. Methods A total of 36 female Sprague-Dawley albino rats were divided into six groups according to the power applied to their sciatic nerves (1, 2, 3, 4, 5 and 6 W, respectively). Pathologic changes were studied by microscopic examination and scored (no change = 0, mild = 1, moderate = 2, severe = 3). Multiple comparisons were provided for all groups by the Bonferroni test (one-way analysis of variance). A p value < 0.05 was accepted as statistically significant. Results The average scores were 2.66 +/- 0.51, 3.66 +/- 0.51, 5.83 +/- 1.83, 10.0 +/- 1.78, 11.0 +/- 1.54, and 13.8 +/- 0.89 in groups 1 to 6, respectively. Significant differences were found between all groups (p < 0.01), except between groups 1 and 2, groups 2 and 3, and groups 4 and 5 (p > 0.05) Variable motor responses and foot deformities were observed at the different power levels. Conclusion Although electrocautery devices provoke motor responses if getting in contact with peripheral nerves as do nerve stimulators, their use induces histopathologically adverse effects even at the lowest power. Their use around peripheral nerves should be avoided.Öğe Effects of Silybum marianum Extract on High-Fat Diet Induced Metabolic Disorders in Rats(Inst Animal Reproduction & Food Research Polish Acad Sciences Olsztyn, 2016) Sayin, Fatma Kubra; Buyukbas, Sadik; Basarali, M. Kemal; Alp, Harun; Toy, Hatice; Ugurcu, VeliSilybum marianum extract (SME) has been used for centuries as a natural remedy for diseases of liver and biliary tract. Lately, it has been promoted as a nutritional supplement for beneficial effects on some risk factors of diabetes and hyperlipidemia. In this study we aimed to determine the effects of SME on high-fat diet (HFD) induced metabolic disorders. Male Sprague Dawley rats were fed HFD for 11 weeks to induce obesity. SME was given to animals for two different durations, for 11 weeks or for 7 weeks. The results showed significant increase in plasma transaminases, total cholesterol (TC), triglycerides (TG), low density lipoprotein cholesterol (LDL-C), leptin, high sensitive C-reactive protein (hsCRP), glucose and insulin along with significant increase in body mass index (BMI) and liver weights in rats fed the HFD diet compared to rats fed with standard rat diet. SME supplementation for different durations raised improvement in the HFD-induced metabolic disorders such as insulin resistance, hyperlipidemia and hepatopathy at different degrees. Our study concludes that SME can be well considered as an effective supplement to improve insulin and leptin sensitivity and hyperlipidemia and to suppress body weight gain.Öğe Effects of Silybum marianum Extract on High-Fat Diet Induced Metabolic Disorders in Rats(Inst Animal Reproduction & Food Research Polish Acad Sciences Olsztyn, 2016) Sayin, Fatma Kubra; Buyukbas, Sadik; Basarali, M. Kemal; Alp, Harun; Toy, Hatice; Ugurcu, VeliSilybum marianum extract (SME) has been used for centuries as a natural remedy for diseases of liver and biliary tract. Lately, it has been promoted as a nutritional supplement for beneficial effects on some risk factors of diabetes and hyperlipidemia. In this study we aimed to determine the effects of SME on high-fat diet (HFD) induced metabolic disorders. Male Sprague Dawley rats were fed HFD for 11 weeks to induce obesity. SME was given to animals for two different durations, for 11 weeks or for 7 weeks. The results showed significant increase in plasma transaminases, total cholesterol (TC), triglycerides (TG), low density lipoprotein cholesterol (LDL-C), leptin, high sensitive C-reactive protein (hsCRP), glucose and insulin along with significant increase in body mass index (BMI) and liver weights in rats fed the HFD diet compared to rats fed with standard rat diet. SME supplementation for different durations raised improvement in the HFD-induced metabolic disorders such as insulin resistance, hyperlipidemia and hepatopathy at different degrees. Our study concludes that SME can be well considered as an effective supplement to improve insulin and leptin sensitivity and hyperlipidemia and to suppress body weight gain.Öğe Effects of strontium ranelate on sutural bone formation: a histological and immunohistochemical study(Australian Soc Orthodontists Inc, 2016) Karatas, Orhan H.; Toy, Ebubekir; Demir, Abdullah; Toy, Hatice; Kozacioglu, SumeyyeAim: Rapid maxillary expansion is performed to correct a skeletal transverse deficiency of the maxilla, which is a frequently encountered orthodontic anomaly. Strontium ranelate (SrR) is a novel agent that has a dual action, involving anti-resorptive and bone-forming effects. The aim of this study was to evaluate the effects of systemically applied SrR on osteoblastic bone formation after maxillary expansion on the mid-palatal suture of rats using histological and immunohistochemical tests. Materials and methods: A total of 24 Wistar rats were randomly divided into two equal groups. In all animals, five-day inter-premaxillary expansion was applied and maintained for a seven-day retention period, during which 625mg/kg/day SrR diluted with saline solution was administered orally to the experimental group. The rats were sacrificed and the tissues prepared for histological and immunohistochemical examinations after the retention period. Results: Osteoblastic activity and the width of the blood vessels in the suture area were significantly increased in the SrR group compared with the control group (p < 0.05). Ossification was also observed to be active under light microscopy by staining with hematoxylin and eosin in the experimental group. Immunohistochemical labelling performed using osteonectin, osteocalcin, TGF-beta and VEGF antibodies revealed significant immunoreactivity in the experimental group (p < 0.05). Conclusion: It may be concluded that SrR contributed to stimulatory osteogenesis in the expansion region. Therefore, a retention period may be shortened and relapse possibly reduced, following the application of SrR after the expansion.Öğe Familial Adenomatous Polyposis: Successful Use of Sirolimus(Nature Publishing Group, 2016) Yuksekkaya, Hasan; Yucel, Aylin; Gumus, Meltem; Esen, Hasan; Toy, Hatice[Abstract Not Availabe]Öğe Hair Follicle Nevus: A Case Report(Galenos Yayincilik, 2014) Mevlitoglu, Inci; Daye, Munise; Unal, Mehmet; Toy, HaticeHair follicle nevus (HFN) is a rare hamartoma showing follicular differentiation. Hamartomas are benign tumoral formations caused by overproduction of normal tissues and cells. HFN was first introduced by Gans et al in 1928. There are a few reports in literature on HFN appearing as multiple lesions, which is often observed as a single papule or nodule. We are hereby present our patient having complaints beginning in early childhood as his lesions might be confused with other dermatoses located on face area. As far as we know, our patient is the first HFN case with bilateral, multiple, perioral, perinasal, periorbital and genital involvements.Öğe Hypomelanosis of Ito: A Case Report(Galenos Yayincilik, 2016) Akyurek, Fatma Tuncez; Kurtipek, Gulcan Saylam; Ataseven, Arzu; Toy, Hatice; Uzun, Meltem[Abstract Not Availabe]Öğe Inflammatory pseudotumor of the breast: A rare case(2013) Gündeş, Ebubekir; Kartal, Adil; Aksoy, Faruk; Toy, HaticeMemenin inflamatuar psödotümörü (MIP) çok nadir bir durumdur. Literatürde sınırlı sayıda olgu bildirilmiştir. Patogenezi tartışmalı bir konudur. Memenin inflamatuvar psödotümörü ön tanısıyla rezeksiyon yapılan 65 yaşında bir kadın hasta irdelendi. Sağ memesinde ağrısız kitle yakınması ile kliniğimize başvurdu. Görüntüleme eşliğinde tru-cut biyopsi yapıldı. Tru-cut biyopsi sonrası patolojik bulgular inflamatuvar psödotümörle uyumluydu. Lokal eksizyon işlemi uygulandı. Yirmi dört aylık takiplerinde nüks saptanmadı.
