Course of sepsis in rats with thyroid dysfunction
Yükleniyor...
Tarih
2017
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: Numerous studies show the relationship between sepsis and thyroid hormones. Virtually all these studies
investigate changes in post-sepsis thyroid hormones and the relationship between these changes and the progression of the disease. Our aim in this study was to investigate the progression of sepsis in rats with thyroid dysfunction.
Material and Methods: The study involved four groups, each containing seven female Wistar albino rats: Group 1:
Sham, Group 2: Control (Sepsis), Group 3: Hyperthyroidism-Sepsis, and Group 4: Hypothyroidism-Sepsis. Group 1 only
received laparotomy. Group 2 only had sepsis. Sepsis was induced in Group 3 and Group 4 following formation of
hyperthyroidism and hypothyroidism, respectively. After 24 hours, relaparotomy and thoracotomy were performed,
and tissue and blood samples were drawn.
Results: Dysfunctions seen in the liver, lungs, and kidneys during sepsis and other findings of sepsis were milder in
the hyperthyroidism group in comparison to both the control and hypothyroidism groups.
Conclusion: The results of Simon’s grade, histopathological organ damage, and laboratory parameters revealed that
the progression of sepsis was milder in the hyperthyroid group than in the hypothyroid and euthyroid groups. The
progression in the hypothyroid group was the most severe. Therefore, the results of the study raise the question of
whether immediate treatment in cases of hypothyroidism and slow return of thyroid function to normal levels in
cases of hyperthyroidism are adequate treatment approaches in patients who may develop sepsis or septic shock.”
To determine the answer to this question, more detailed studies are required with a higher number of subjects.
Açıklama
WOS:000410004200009
PubMed ID:28944329
PubMed ID:28944329
Anahtar Kelimeler
Cerrahi, Hyperthyroidism, Hypothyroidism, Organ dysfunction, Sepsis
Kaynak
Turkish Journal of Surgery
WoS Q Değeri
Scopus Q Değeri
Cilt
33
Sayı
3
Künye
Karaibrahimoğlu, A., Taşçı, H. İ., Erikoğlu, M., Toy, H. (2017). Course of sepsis in rats with thyroid dysfunction. Turkish Journal of Surgery, 33, 3, 175-179.
