Course of sepsis in rats with thyroid dysfunction

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dc.authoridMehmet Erikoğlu: 0000-0002-1834-8633en_US
dc.authoridAdnan Karaibrahimoğlu: 0000-0002-8277-0281en_US
dc.contributor.authorTaşcı, Halil İbrahim
dc.contributor.authorErikoğlu, Mehmet
dc.contributor.authorToy, Hatice
dc.contributor.authorKaraibrahimoğlu, Adnan
dc.date.accessioned2020-01-18T21:02:57Z
dc.date.available2020-01-18T21:02:57Z
dc.date.issued2017
dc.departmentNEÜ, Meram Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Genel Cerrahi Anabilim Dalıen_US
dc.departmentNEÜ, Meram Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Tıbbi Patoloji Anabilim Dalıen_US
dc.departmentNEÜ, Meram Tıp Fakültesi,Temel Tıp Bilimleri Bölümü, Tıp Eğitimi ve Bilişimi Anabilim Dalıen_US
dc.descriptionWOS:000410004200009en_US
dc.descriptionPubMed ID:28944329en_US
dc.description.abstractObjective: Numerous studies show the relationship between sepsis and thyroid hormones. Virtually all these studies investigate changes in post-sepsis thyroid hormones and the relationship between these changes and the progression of the disease. Our aim in this study was to investigate the progression of sepsis in rats with thyroid dysfunction. Material and Methods: The study involved four groups, each containing seven female Wistar albino rats: Group 1: Sham, Group 2: Control (Sepsis), Group 3: Hyperthyroidism-Sepsis, and Group 4: Hypothyroidism-Sepsis. Group 1 only received laparotomy. Group 2 only had sepsis. Sepsis was induced in Group 3 and Group 4 following formation of hyperthyroidism and hypothyroidism, respectively. After 24 hours, relaparotomy and thoracotomy were performed, and tissue and blood samples were drawn. Results: Dysfunctions seen in the liver, lungs, and kidneys during sepsis and other findings of sepsis were milder in the hyperthyroidism group in comparison to both the control and hypothyroidism groups. Conclusion: The results of Simon’s grade, histopathological organ damage, and laboratory parameters revealed that the progression of sepsis was milder in the hyperthyroid group than in the hypothyroid and euthyroid groups. The progression in the hypothyroid group was the most severe. Therefore, the results of the study raise the question of whether immediate treatment in cases of hypothyroidism and slow return of thyroid function to normal levels in cases of hyperthyroidism are adequate treatment approaches in patients who may develop sepsis or septic shock.” To determine the answer to this question, more detailed studies are required with a higher number of subjects.en_US
dc.identifier.citationKaraibrahimoğlu, A., Taşçı, H. İ., Erikoğlu, M., Toy, H. (2017). Course of sepsis in rats with thyroid dysfunction. Turkish Journal of Surgery, 33, 3, 175-179.en_US
dc.identifier.doi10.5152/turkjsurg.2017.3621en_US
dc.identifier.endpage179en_US
dc.identifier.issn2564-6850en_US
dc.identifier.issn2564-7032en_US
dc.identifier.issue3en_US
dc.identifier.pmid28944329en_US
dc.identifier.startpage175en_US
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TWpRek1qUXpNdz09/course-of-sepsis-in-rats-with-thyroid-dysfunction
dc.identifier.urihttps://hdl.handle.net/20.500.12452/1382
dc.identifier.volume33en_US
dc.identifier.wosWOS:000410004200009en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US]
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCerrahien_US
dc.subjectHyperthyroidismen_US
dc.subjectHypothyroidismen_US
dc.subjectOrgan dysfunctionen_US
dc.subjectSepsisen_US
dc.titleCourse of sepsis in rats with thyroid dysfunctionen_US
dc.typeArticleen_US

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