Yazar "Ural, Onur" seçeneğine göre listele
Listeleniyor 1 - 14 / 14
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Bir Üniversite Hastanesi Öğrencileri, Araştırma Görevlileri ve Öğretim Üyelerinin El Hijyeni Hakkındaki Bilgi Düzeyleri(2018) Demir, Lütfi Saltuk; Aktuğ Demir, Nazlım; Sümer, Şua; Ural, OnurAmaç: Bu çalışmanın amacı bir üniversite hastanesi öğrencilerinin, araştırma görevlilerinin ve öğretim üyelerinin el hijyeni hakkında farkındalığı ve bilgi düzeyinin değerlendirilmesidir. Yöntemler: Bu çalışma bir üniversite hastanesinde okuyan 892 öğrenci, fakültemizde çalışan 243 araştırma görevlisi ve 131öğretim üyesi olmak üzere toplam 1266 kişi üzerinde yapıldı. Literatür taraması sonrasında hazırlanan anketler katılımcılara yüz yüze uygulandı. Bulgular: Çalışmaya katılan 1266 kişinin 657 (%51.9)’si erkek, 609 (%48.1)’u kadındı. Çalışmaya katılan öğrencilerin %91’inin, araştırma görevlilerinin %73.2’sinin son 5 yıl içerisinde el hijyeni eğitimi aldığı saptandı. Araştırma görevlilerinin %23.1’inin, öğrencilerin %38.7’sinin son bir yıl içerisinde eğitim aldığı tespitedildi. Öğretim üyelerinin hiçbirinin son 5 yıl içerisinde el hijyeni eğitimi almadığı saptandı. Çalışmamızda son bir yıl içerisinde eğitim alanlarda bilgi düzeyi en yüksek bulundu (p0.001). Öğrencilerin bilgi düzeyi, araştırma görevlisi ve öğretim üyelerinden yüksek olarak tespit edildi (p0.01). Çalışmaya katılanların %54.2’si el hijyenine uyum oranını orta, %23.1’i iyi, %32.7’si kötü olarak değerlendirdi. Katılımcılar tarafından en çok doğrubilinen bilgi “her hastada eldiven değiştirilmelidir” iken en çok yanlış bilinen bilgi “eldiven giymek el hijyeni yerine geçer” olarak saptandı. Katılımcılar arasında el hijyenine uyumsuzluğun en önemli nedeni iş yoğunluğu olarak belirtildi. Sonuçlar: Hastanemizde el hijyenine uyumun artırılmasına yönelik olarak yapılan çalışmaların sürekliliğinin sağlanmasının ne kadar önemli olduğu ve ayrıca eğitimlerin hastanede çalışan tüm personele (özellikle de doktorlara) ulaştırılmasının gerekliliği gözlendi.Öğe A CASE WITH ABSENCE OF B LYMPHOCYTES(Springer/Plenum Publishers, 2014) Ozdemir, Hulya; Artac, Hasibe; Ural, Onur; Karabagli, Hakan; Caliskaner, A. Zafer[Abstract Not Availabe]Öğe Clinical and Laboratory Characteristics of COVID-19 Cases Followed in Selcuk University Faculty of Medicine(Doc Design Informatics Co Ltd, 2020) Sumer, Sua; Ural, Onur; Aktug-Demir, Nazlim; Cifci, Seyma; Turkseven, Burcu; Kilincer, Abidin; Turk-Dagi, HaticeObjective: Understanding the natural course of COVID-19 and determining its clinical findings are essential for early diagnosis and treatment. In this study, we aimed to investigate clinical and laboratory characteristics of cases followed with a diagnosis of COVID-19 in Selcuk University Faculty of Medicine Department of Infectious Diseases and Clinical Microbiology. Methods: Among patients followed with a diagnosis of possible/definitive COVID-19, those with a positive SARS-CoV-2 RT-PCR test were evaluated retrospectively in terms of their clinical, laboratory and thorax computed tomography (CT) data. Results: Among 407 patients followed with a diagnosis of possible/definitive COVID-19, 149 (36.6%) were SARS-CoV-2 RT-PCR test-positive. 82 (55%) of the patients were female and 67 (45%) were male. Mean age was 49.3 +/- 7.6 years. 11 (7.4%) were health care workers. While the most common symptom was cough with 46.3%, fever was observed in 29.5%, sore throat in 27.5% and malaise in 26.8% of the patients. 94 (63.1%) of the patients had underlying diseases. Hypertension and diabetes mellitus were the most common underlying disease. Laboratory findings were leukopenia in 12 (8.1%), lymphopenia in 34 (22.8%), thrombocytopenia in 24 (16.1%), elevated D-dimer levels in 43 (28.9%), elevated lactate dehydrogenase levels in 73 (49%), and elevated C-reactive protein (CRP) levels in 45 (30.2%) patients. While 71 (47.6%) of the patients had normal thorax CT, 43 (28.9%) had mild pneumonia, and 35 (23.5%) moderate pneumonia. D-dimer and CRP levels were higher in those with pneumonia than those without pneumonia (p=0.001 and p=0.001, respectively). As the pneumonia level increased, the increase of D-dimer and CRP levels became evident (p=0.003 and p=0.001, respectively). Conclusions: The clinical course of COVID-19 patients varies. It is noteworthy that there is a positive correlation between the severity of pneumonia and the increase in D-dimer and CRP levels in COVID-19.Öğe Concomitant neuromyelitis optica and cytomegalovirus-associated retinitis in an immunocompetent female(Springer Heidelberg, 2014) Tokgoz, Serhat; Dogan, Ebru Apaydin; Gumus, Haluk; Ilhan, Nurhan; Ural, Onur[Abstract Not Availabe]Öğe Evaluation of Annexin-1 (ANXA-1), Annexin-2 (ANXA-2) and Bone Morphogenetic Protein-7 (BMP-7) Serum Levels in Patients Followed Up With A Diagnosis of COVID-19(Ankara Microbiology Soc, 2022) Ural, Onur; Kiratli, Hatice Esranur; Sumer, Sua; Aktug Demir, Nazlim; Yilmaz Kirik, Sema; Vatansev, Husamettin; Akyurek, FikretCoronavirus disease 2019 (COVID-19) is a global health problem caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). SARS-CoV-2 infection may present with clinical pictures ranging from asymptomatic or mild forms to respiratory failure requiring intensive care follow-up and mechanical ventilation. The course of this disease with different clinical presentations raises many immunological questions. This study aimed to evaluate the serum levels of Annexin-1 (ANXA-1), Annexin-2 (ANXA-2) and bone morphogenetic protein-7 (BMP-7) in patients diagnosed with COVID-19 and to investigate whether these markers are associated with lung involvement. The study was conducted in 173 patients who were followed and treated with the diagnosis of COVID-19 and 51 healthy control group. Patients were primarily divided into two groups based on the presence of typical lung involvement (ground glass opacities, consolidation, and both) in the thoracic computed tomography (CT) scans for COVID-19. Those who found to have involvement in thoracic CT scans were divided into three groups as mild (< 33%), moderate (34-66%), and severe (> 67%) according to the extent of their lesions. Of the 173 patients included in the study, 130 had typical thoracic CT involvement for COVID-19, while 43 did not. ANXA-1, ANXA-2 and BMP-7 values were found to be higher in the patients than the control group (p=0.001, p=0.001, p=0.001). ANXA-2 levels were higher in patients with thoracic CT involvement than those without thoracic CT involvement (p=0.023). In addition, when the patients were evaluated according to their thorax CT involvement levels, it was found that as the lung involvement levels increased, ANXA-2 increased, ANXA-1 decreased, and BMP-7 levels did not change. While the increase in ANXA-2 was statistically significant, the decrease in ANXA-1 was not found statistically significant. When the relationship between the laboratory parameters and the thorax CT involvement level was evaluated; it was found that, the lymphocyte and thrombocyte counts decreased as the thorax CT involvement increased, and lactate dehydrogenase (LDH), ferritin, procalcitonin (PCT), C-reactive protein (CRP), D-dimer and troponin levels were increased. While no significant correlation was found between ANXA-1 and BMP-7 and laboratory parameters, a positive correlation was found between ANXA-2 and leukocyte count, LDH, troponin, PCT, ferritin, D-dimer, and CRP. The data obtained in our study suggest that the ANXA-2 level at the time of admission was related with the lung involvement and the level of involvement of the disease. As a result, molecular studies are needed today to understand the pathogenesis of COVID-19 and to investigate new treatment targets. Evaluation of ANXA-2 level may be important in predicting the level of lung involvement due to COVID-19.Öğe Evaluation of Depression, Anxiety Level and Quality of Life in Patients With Chronic Hepatitis B and Inactive Hepatitis B Virus Carriers(Aves, 2017) Yigit, Ozge; Ural, Onur; Aktug-Demir, Nazlim; Sumer, Sua; Guler, Ozkan; Demir, Lutfi SaltukObjective: The objective of this study was to compare the anxiety, depression and quality of life scores of chronic hepatitis B (CHB) patients and inactive hepatitis B virus (HBV) carriers with healthy control subjects and to demonstrate the need for a multidisciplinary approach in the follow-up and treatment of patients with HBV infection. Methods: The study was carried out by comparing 200 subjects including 100 CHB patients and 100 inactive HBV carriers, who were admitted to the Outpatient Clinic of Infectious Diseases and Clinical Microbiology Department, Faculty of Medicine, Selcuk University between August 2013 and August 2014 with 100 healthy control subjects. All subjects were given Hospital Anxiety and Depression (HAD) Scale and Short Form-36 (SF-36) to assess their quality of life. Results: Based on the HAD Scale, anxiety risk among the carriers was higher than the control group (p=0.031). Depression risk in the patient (p=0.031) and carrier groups (p=0.046) were higher than the control group. There was no significant difference between the patient and carrier groups with regard to anxiety risk or depression risk (p>0.05). Females had higher anxiety risk in the patient (p=0.015), carrier (p=0.035) and control (p=0.001) groups. Depression risk was also higher in females in the patient (p=0.037) and carrier (p=0.038) groups. There were no significant relations between marital status, family type, place of living and anxiety and depression risks (p>0.05). Three quality of life parameters including general health, role limitations due to physical health and vitality scores in the inactive HBV carriers and CHB patients were lower than those of the control group (p<0.05). Conclusions: Psychological state of the patients who are chronically infected with HBV should not be neglected during treatment and follow-up. If a psychiatric disturbance is identified, effective treatment will increaseÖğe An evaluation of matrix metalloproteinase-9 (Mmp-9) and tissue inhibitor metalloprotein- ase-1 (Timp-1) Serum levels and the Mmp-9/Timp-1 Ratio in Covid-19 patients(Makerere Univ, Coll Health Sciences,Sch Med, 2023) Demir, Nazlim Aktug; Kirik, Sema Yilmaz; Sumer, Sua; Ural, Onur; Kiratli, Hatice Esranur; Vatansev, Husamettin; Hayatsal, Esra PaydasBackground: The progression of COVID-19 has different clinical presentations, which raises a number of immunological questions. Objectives: This study aimed to investigate MMP-9 and TIMP-1 levels in patients diagnosed with COVID-19 and whether the MMP-9/TIMP-1 ratio is associated with lung involvement in COVID-19.Methods: This study was conducted with 192 patients and 45 healthy controls. ELISA was used to measure the MMP-9 and TIMP-1.Results: The MMP-9 and TIMP-1 levels of the patients were found to be higher than those of the controls. MMP-9 and TIMP-1 were detected more in patients with lung involvement on chest CT scans than in those with no lung involvement on chest CT scans. A comparison of lung involvement levels revealed no difference was found between the groups. The MMP-9/TIMP-1 ratio was 5.8 in the group with lung involvement on chest CT scans and 6.1 in the group without lung involvement on chest CT scans. No difference was found between the two groups. A comparison with respect to lung involvement levels showed that the MMP-9/TIMP-1 ratio difference was found between the groups.Conclusion: Diagnostic and treatment methods targeting MMP-9 activity or neutrophil activation may be important in predict-ing lung involvement in COVID-19 and directing clinical outcomes.Öğe Evaluation of Patients Followed by COVID-19 After Quarantine(Bilimsel Tip Yayinevi, 2020) Ural, Onur; Sumer, Sua; Aktug Demir, Nazlim; Yalcinkaya, Emine; Ucan, Elif; Demir, Lutfi SaltukIntroduction: The COVID-19 pandemic continues to affect the world with serious number of cases and deaths. For this reason, knowing the clinical findings and course of the disease is important for early diagnosis and treatment. In this article, COVID-19 cases followed up after quarantine were discussed. Materials and Methods: In this study, the data of 99 patients who were followed up during travel and post-Umrah quarantine between 31 March and 15 April 2020 were retrospectively reviewed. Results: Of the 99 patients included in the study, 66 (66.7%) were females, 33 (33.3%) were males, and mean age was 59.8 +/- 11.4 years. SARS-CoV-2 RT-PCR test was positive at the time of admission in 97 (98.0%) of the 99 patients. Thirty-nine (39.4%) of the patients were symptomatic and 25.3% of the patients had cough, 8.1% had fever, and 7.1% had shortness of breath. While SARS-CoV-2 RT-PCR test was negative in 2 (3.3%) of the 60 patients without complaints, 58 (96.7%) of them were positive for SARS-CoV-2 RT-PCR test. Leukopenia was detected as 3%, lymphopenia 66.7%, D-dimer height 47.5%, LDH elevation 38.4%, CRP elevation 45.5%. Ground glass opacities were present in 81 (81.8%) of the patients with lung involvement, and consolidation areas were present in 40 patients (40.4%). Underlying disease was present in 38 (38.4%) of the patients. Hypertension and diabetes mellitus were the most common underlying diseases. It was observed that 89 (89.4%) of our cases had negative SARS-CoV-2 RT-PCR test on the 5th day. Conclusion: COVID-19 infection is an infectious disease that can present with many different clinics. In asymptomatic COVID-19 cases, lung involvement findings and disorders in laboratory parameters may be observed. It should be kept in mind that asymptomatic cases pose a risk in terms of transmission.Öğe How should procalcitonin and C-reactive protein levels be interpreted in haemodialysis patients?(Wiley, 2018) Demir, Nazlim A.; Sumer, Sua; Celik, Gulperi; Afsar, Rengin E.; Demir, Lutfi S.; Ural, OnurBackground: Procalcitonin (PCT) and C-reactive protein (CRP) are used most widely in the diagnosis/treatment of bacterial infections. These are not infection-specific and may also show increases in other inflammation-causing cases. Aim: To establish a new cut-off value for PCT and CRP to eliminate confusion in the diagnosis and treatment of bacterial infections in haemodialysis (HD) patients. Methods: A total of 1110 patients, 802 with undocumented infection and 308 with documented infection, was included in the study. Results: A total of 802 patients with undocumented infection had a mean CRP value of 12.2 +/- 9.6 mg/dL and a mean PCT value of 0.51 +/- 0.96 ng/mL and the 308 patients with documented infection had a mean CRP value of 125.9 +/- 83.3 mg/dL and a mean PCT value of 13.9 +/- 26.9 ng/mL at the time of admittance. In HD patients, the cut-off values for CRP was determined as 19.15 mg/dL and for PCT as 0.685 ng/mL in the presence of infection. The use of these two parameters in combination (CRP = 19.15 mg/dL and PCT = 0.685 ng/mL) was found to have 95% positive predictive value (PPV) and 93% negative predictive value (NPV) for the diagnosis of infectious diseases in HD patients. When CRP = 100 mg/dL and PCT = 5 ng/mL, this was found to have 100% PPV and 94% NPV for the diagnosis of sepsis in HD patients. Conclusion: We specified PCT and CRP cut-off values with high PPV and NPV for revealing the presence of bacterial infection and sepsis in HD patients.Öğe Is serum high-mobility group box 1 (HMGB-1) level correlated with liver fibrosis in chronic hepatitis B?(Lippincott Williams & Wilkins, 2017) Inkaya, Ahmet Cagkan; Demir, Nazlim Aktug; Kolgelier, Servet; Sumer, Sua; Demir, Lutfi Saltuk; Ural, Onur; Pehlivan, Fatma SeherBackground: High-mobility group box 1 (HMGB1), identified as an alarmin molecule, was shown to have a role in virus-triggered liver injury. We aimed to evaluate the association between serum levels of HMGB1 and liver fibrosis. Method: This cross-sectional case-control study included 189 chronic hepatitis B (CHB) patients and 51 healthy controls. All patients underwent liver biopsy and modified Knodell scoring system used to determine the fibrosis level in CHB patients. Serum HMGB1 levels were determined with enzyme-linked immunosorbent assay (ELISA). Results: Mean serum HMGB1 levels of patients (58.1 +/- 54.7) were found to be higher than those of the control group (7.1 +/- 4.3) (P=. 001). HMGB1 levels of patients with advanced-stage fibrosis (stage 4 and 5) were detected to be higher than those of patients with early-stage fibrosis (stage 1-3). However, this difference was not statistically significant (P>. 05). Albumin levels of fibrosis 3 and 4 patients were lower than fibrosis 1 and 2 patients. ALT, HBV DNA, and AFP levels of fibrosis 5 patients were significantly higher than fibrosis 1 and 2 patients, and their platelet and albumin levels are lower than fibrosis 1 and 2 patients (P<. 001). In a logistic regression model, fibrosis levels were correlated with ALT values and inversely correlated with albumin levels. Conclusion: In this study, we demonstrated that serum HMGB1 levels increase in the early course of liver injury and this increase is not correlated with severity of the liver damage.Öğe Kronik Hepatit B Hastaları ve İnaktif Hepatit B Virusu Taşıyıcılarında Depresyon, Anksiyete Düzeyleri ve Yaşam Kalitesinin Değerlendirilmesi(2017) Demir, Lütfi Saltuk; Yiğit, Özge; Ural, Onur; Aktuğ Demir, Nazlım; Sümer, Şua; Güler, ÖzkanAmaç: Bu çalışmada kronik hepatit B (KHB) hastaları ve inaktif hepatit B virusu (HBV) taşıyıcılarında sağlıklı kontrol grubuna göre anksiyete, depresyon ve yaşam kalitesi skorlarının karşılaştırılması, HBV infeksiyonu olan kişilerin takip ve tedavisi sırasında multidisipliner yaklaşımların gerekliliğinin gösterilmesi amaçlandı. Yöntemler: Çalışma Ağustos 2013-Ağustos 2014 tarihleri arasında Selçuk Üniversitesi, Tıp Fakültesi, İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Polikliniği'ne başvuran 100 KHB hastası, 100 inaktif HBV taşıyıcısı ve 100 sağlıklı kontrol olmak üzere toplam 300 kişi üzerinde yapıldı. Tüm katılımcılara anksiyete ve depresyonu değerlendirmek amacıyla Hastane Anksiyete ve Depresyon (HAD) Ölçeği ve yaşam kalitelerini değerlendirmek amacıyla "Short Form-36" (SF-36) uygulandı. Bulgular: HAD Ölçeğine göre taşıyıcı grupta anksiyete riski kontrol grubundan yüksek bulundu (p0.031). Hasta grubu (p0.031) ve taşıyıcı grupta (p0.046) depresyon riski kontrol grubuna göre yüksek bulundu. Hasta grubu ve taşıyıcı grup arasında anksiyete riski ve depresyon riski açısından anlamlı bir fark yoktu (p0.05). Hasta grubu (p0.015), taşıyıcı grup (p0.035) ve kontrol grubunda (p0.001) kadın hastalarda anksiyete riskinin erkek hastalara göre yüksek olduğu görüldü. Hasta grubu (p0.037) ve taşıyıcı grupta (p0.038) kadın hastalarda depresyon riskinin yüksek olduğu görüldü. Tüm olguların medeni durumları, aile tipi, yaşadıkları yerle anksiyete ve depresyon riskleri arasında fark bulunmadı (p0.05). Yaşam kalitesi parametrelerinden genel sağlık, fiziksel rol güçlüğü ve vitalite skorları, inaktif HBV taşıyıcıları ve KHB hastalarında kontrol grubuna göre düşük bulundu (p<0.05). Sonuçlar: HBV ile kronik olarak infekte kişilerin takip ve tedavileri sırasında ruhsal durumları göz ardı edilmemelidir. Saptanan psikiyatrik bozuklukların etkin şekilde tedavi edilmesi bu olguların sağlıkla ilişkili yaşam kalitelerinin artmasını sağlayacak ve tedaviye olan uyumlarını artıracaktır.Öğe Kronik hepatit B'de fibrotest ve actitest karaciğer biyopsisine alternatif olabilir mi?(2016) Demir, Lütfi Saltuk; Sümer, Şua; Aktuğ Demir, Nazlım; Kölgelier, Servet; Ural, OnurAmaç: Bu çalışmada kronik hepatit B (KHB)'de karaciğer biyopsisinde saptanan fibrozis ve inflamasyon derecesi referans alınarak fibrotestin (FT) fibrozisi ve actitestin (AT) nekroinflamatuar aktiviteyi belirlemedeki duyarlılığının araştırılması amaçlandı. Gereç ve Yöntem: Bu prospektif çalışmaya 2013 yılı içerisinde takip edilen 53 KHB hastası dahil edildi. Biyopsiler modifiye Knodell skorlama sistemine gore değerlendirildi. Karaciğer biyopsisi yapıldığı gün hastalardan FT ve AT için kan örneği alındı. Bulgular: Çalışmaya alınan hastaların 22'si kadın, 31'i erkekti. KHB hastalarında karaciğer biyopsisi ve FT karşılaştırılmasında ciddi fibrozisi tespit etmek için FT'nin duyarlılığı %93.5, seçiciliği ise %54.5 olarak tespit edildi. FT'nin pozitif prediktif değeri (PPD) %74.3, negatif prediktif değeri (NPD) ise %85.7 olarak hesaplandı. FT için ROC analizi sonucu eğri altında kalan alan %75.1'ti (p0.003). KHB hastalarında karaciğer biyopsisi ve AT karşılaştırılmasında ise ciddi nekroinflamasyonun tespiti için AT'nin duyarlılığı %89.2, seçiciliği %64'tü. PPD %73.5 ve NPD ise %84.2 olarak hesaplandı. AT için ROC analizi sonucu eğri altında kalan alan % 65'ti (p0.001). Sonuç: KHB'de FT ve AT'nin ciddi fibrozis ve nekroinflamasyonu göstermedeki duyarlılıkları yüksekti. Bununla birlikte FT ve AT biyopsi yapılmaksızın tek başına kullanılabilecek bir belirteç olarak görülmemektedir.Öğe Serum Neutrophil Gelatinase-Associated Lipocalin Levels in Acute Brucellosis and Brucellar Spondylodiscitis(Ankara Microbiology Soc, 2022) Sumer, Sua; Aktug Demir, Nazlim; Demir, Lutfi Saltuk; Findik, Duygu; Kolgelier, Servet; Ural, OnurBrucellosis is a zoonotic infectious disease caused by Brucella spp., an intracellular bacterium. The complications of acute Brucellosis may affect all organs and systems. The most common complication of the disease is musculoskeletal system involvement. The neutrophil gelatinase-associated lipocalin (NGAL) is a marker of neutrophil formation and acts as a siderophore-binding protein to prevent bacterial iron uptake and its use as a marker in the diagnosis and follow-up of bacterial infections is being investigated. The aim of this study was to measure the serum levels of NGAL in patients with acute Brucellosis and Brucellar spondylodiscitis, and to determine whether there is a correlation between NGAL levels and the progression and complications of the disease. This prospective case control study was conducted with 240 patients and 120 healthy controls. The diagnosis of acute Brucellosis was established when a person was asked to take an STA test due to clinical symptoms within the past eight weeks, and the test result that exceeded 1/160, or a 4-fold titer increase was found in the STA test after an interval of two weeks, and/or there was Brucella spp. growth in the blood culture. A contrasted lumbar magnetic resonance (MR) scan was performed on patients diagnosed with acute Brucellosis who had lower back pain. Presence of spondylodiscitis was assessed radiologically with contrasted lumbar MR images. NGAL levels were determined with ELISA assay. The median NGAL value was found to be 456.67 ng/L (101.41-5804.41 ng/L) in patients with acute Brucellosis and 113.84 ng/L (58.29-542.34 ng/L) in the control group. The median NGAL value was statistically higher in the patients than the control group (p= 0.001). Brucellar spondylodiscitis was detected in 57 (23.7%) of 240 patients diagnosed with acute Brucellosis. The median NGAL value was 1885.62 ng/L (143.21-5804.41 ng/L) in patients with Brucellar spondylodiscitis, and 356.87 ng/L (101.41-1874.07 ng/L) in those who did not have Brucellar spondylodiscitis. This difference was statistically significant (p= 0.001). Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) values were found to be higher in patients who had Brucellar spondylodiscitis. Blood cultures were drawn from 186 (77.5%) of the 240 patients diagnosed with acute Brucellosis. The blood culture positivity rate was 36.02%. Patients whose blood cultures were positive had higher NGAL levels (p= 0.001). The blood culture positivity rate was higher in patients who were diagnosed with Brucellar spondylodiscitis (p= 0.001). A regression analysis showed that female gender and high levels of NGAL, ESR, and alanine aminotransferase (ALT) could be used as predictors of Brucellar spondylodiscitis. The explanatoriness of the model was 82.3%. Although determination of NGAL levels is seen as a useful marker in the diagnosis of acute Brucellosis and predicting the presence of Brucellar spondylodiscitis, more comprehensive studies are required to be used in clinical practice in regions where Brucellosis is endemic.Öğe Transfusion transmitted virüs (ttv) prevalansıinaktif hepatit b taşıyıcılarında hemodiyalizden etkileniyor mu?(2018) Kölgelier, Servet; Aktuğ Demir, Nazlım; Şua , Sümer; Demir, Lütfi Saltuk; Arpacı, Abdullah; Ural, OnurAmaç: Bu çalışmada, hemodiyaliz tedavisi uygulanan ve uygulanmayan inaktif hepatit B taşıyıcılarında Transfusion TransmittedVirus (TTV) prevalansının saptanması amaçlandı.Gereç ve Yöntem: Bu çalışma, hemodiyaliz tedavisi uygulanan 50 inaktif hepatit B hastası ve renal fonksiyonları normal olan 40 inaktifhepatit B olgusu üzerinde yapıldı. Hastalardan alınan serum örneklerinden ELİSA kiti ile Anti TTV IGG çalışıldı. Veriler Ki-karetesti ile değerlendirildi.Bulgular: 50 hemodiyaliz hastasının 39’unda (%78) Anti TTV IGG pozitif saptanırken, 40 hemodiyaliz tedavisi uygulanmayan inaktifhepatit B hastasının 8’inde (%20) Anti TTV IGG pozitifliği saptandı. Bu fark istatistiki olarak anlamlı idi (p0.001).Sonuç: Hemodiyaliz tedavisi uygulanan hastalarda TTV seropozitifliğinin yüksek olması nedeniyle, hepatit virüslerinin bulaşının önlenmesiiçin bu ünitelerde temizlik, dezenfeksiyon ve enfeksiyon kontrolüne yönelik standart önlemlerin daha dikkatli uygulanmasıgerektiğini düşünüyoruz.
