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Yazar "Uzun, Sema Tuncer" seçeneğine göre listele

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  • Küçük Resim Yok
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    Anesthetic management for cesarean birth in pregnancy with the novel coronavirus (COVID-19)
    (Elsevier Science Inc, 2020) Yilmaz, Resul; Kilic, Fatma; Arican, Sule; Hacibeyoglu, Gulcin; Suslu, Halime; Koyuncu, Mustafa; Uzun, Sema Tuncer
    [Abstract Not Availabe]
  • Küçük Resim Yok
    Öğe
    Combined erector spinae plane and interscalene brachial plexus block for surgical anesthesia of scapula fracture
    (Elsevier Science Inc, 2019) Kilicaslan, Alper; Hacibeyoglu, Gulcin; Goger, Esra; Uzun, Sema Tuncer; Ozer, Mustafa
    [Abstract Not Availabe]
  • Küçük Resim Yok
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    A Comparison of Ketamine and Paracetamol for Preventing Remifentanil Induced Hyperalgesia in Patients Undergoing Total Abdominal Hysterectomy
    (Ivyspring Int Publ, 2012) Yalcin, Naime; Uzun, Sema Tuncer; Reisli, Ruhiye; Borazan, Hale; Otelcioglu, Seref
    Background: The aim of this prospective, randomized, placebo-controlled study was to compare the effects of ketamine and paracetamol on preventing remifentanil induced hyperalgesia. Methods: Ninety patients undergoing total abdominal hysterectomy were randomly assigned to one of three groups to receive (I) either saline infusion; (II) 0.5 mg/kg ketamine iv bolus or (III) 1000 mg iv paracetamol infusion before induction of anesthesia. Until the skin closure, anesthesia was maintained with 0.4 mu g/kg/min remifentanil infusion in all groups, additionally Group II received 5 mu g/kg/min ketamine infusion. Pressure pain thresholds were measured the day before surgery during the preoperative visit for baseline measurements and repeated postoperatively at 24 and 48 hours (hrs). Pressure pain thresholds were established by digital algometer on three different peri-incisional regions for calculating mean pressure pain threshold values. The visual analogue scale (VAS), sedation scores, total morphine consumption and side effects were assessed postoperatively. Results: Demographic characteristics, duration of surgery and anesthesia were similar in the three groups. Pain thresholds at the incision region were significantly lower at 24 and 48 hrs postoperatively in Group I than the other Groups (p<0.05). In Group., pain thresholds were lower compared with preoperative baseline values. Thresholds in Group II and Group III were higher compared with preoperative baseline values (p<0.05) The VAS scores at all evaluation times were significantly higher in Group. when compared to Group.. and at 2, 4, 6,12 hrs were higher in Group I than Group III (p<0.05). The morphine consumption was higher in Group III at 24 and 48 hrs postoperatively (p<0.05). Conclusion: It was shown that ketamine and paracetamol were both effective in preventing remifentanil induced hyperalgesia.
  • Küçük Resim Yok
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    Comparison of the C-MAC D-Blade, Conventional C-MAC, and Macintosh Laryngoscopes in Simulated Easy and Difficult Airways
    (Aves, 2014) Kilicaslan, Alper; Topal, Ahmet; Erol, Atilla; Uzun, Sema Tuncer
    Objective: Recently, to further enhance the potential in the management of difficult airways, the highly angulated D-Blade was added to the C-MAC system. The purpose of this study was to investigate the laryngoscopic view and intubation parameters using the new C-MAC D-Blade in comparison to the conventional C-MAC video laryngoscope and Macintosh direct laryngoscope in simulated easy and difficult airways. Methods: We recruited 26 experienced anaesthesia providers into a randomized trial. Each performed tracheal intubation of a Laerdal SimMan r manikin with each laryngoscope in the following laryngoscopy scenarios: (1) normal airway, (2) cervical spine immobilization, and (3) tongue edema. The intubation times, success rates, number of intubation attempts, laryngoscopic views, and severity of dental compression were recorded. Results: In all scenarios, video laryngoscopes provided better laryngeal exposure than the ML and appeared to produce less dental pressure. In the cervical spine immobilization scenario, D-Blade caused less dental pressure and showed better Cormack-Lehane (CL) classes than the other devices (p<0.001). There were no differences between video laryngoscopes in success of tracheal intubation (p>0.05). The CMAC provided the most rapid intubation. The rate of failure was 19% with ML. In the tongue edema scenario, the CMAC provided the most rapid and successful intubation (p<0.001). There were no differences between video laryngoscopes in laryngoscopic views according to CL classification and dental pressure (p>0.05). The rate of failure was 46% with the ML and 7% with the D-Blade. Conclusion: The CMAC D-Blade caused less dental pressure than the conventional C-MAC and ML in the cervical immobilization scenario. The conventional CMAC performed better than the D-Blade and ML in the tongue edema scenario. These two video laryngoscopes may complement each other in various difficult airway situations.
  • Küçük Resim Yok
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    Comparison of the effect of the Trendelenburg and passive leg raising positions on internal jugular vein size in critically ill patients
    (E-Century Publishing Corp, 2015) Gok, Funda; Sarkilar, Gamze; Kilicaslan, Alper; Yosunkaya, Alper; Uzun, Sema Tuncer
    Central vein catheterization is a common procedure performed on patients under intensive care. The safe and successful placement of the central venous catheter depends on vein size. Although used for this purpose, the Trendelenburg position can be hazardous in some patients. The aim of this study was to compare the effects of the Trendelenburg and passive leg raising (PLR) positions on the size of the right internal jugular vein (IJV) in mechanically ventilated patients under intensive care. Seventy-eight mechanically ventilated patients under intensive care were included into the study. Sonographic images of the right IJV were recorded in supine (control), 10 degrees Trendelenburg and 40 degrees PLR positions. Anterior-posterior and transverse diameter, cross-sectional area (CSA), and depth were calculated from the recorded images. The size of the right IJV (CSA, transverse and vertical diameters) was significantly larger in the Trendelenburg and PLR positions than in supine position. An increase of 26% in the IJV CSA was obtained in the Trendelenburg position and 23% in the PLR position, compared to the supine position. There was no significant difference between the measurements obtained from the Trendelenburg and PLR positions. The study shows that the Trendelenburg and PLR positions increase the size of the IJV to a similar extent in mechanically ventilated patients under intensive care.
  • Küçük Resim Yok
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    The Effect of Transversus Abdominis Plane Block in Inguinal Hernioplasty on Chronic Pain
    (Modestum Ltd, 2015) Topal, Ahmet; Sargin, Mehmet; Kilicaslan, Alper; Uzun, Sema Tuncer
    The aim of the current study was to retrospectively evaluate the efficacy of IV analgesia after general anesthesia, transversus abdominis plane (TAP) block after the induction of general anesthesia and before the surgery and spinal analgesia on development of chronic pain following inguinal hernia repair. Forty patients, who underwent hernioplasty for the first-time and for whom at least 6 months had passed since the operation date were included in the study, were included in each group as follows: Group G received IV analgesia with general anesthesia; Group T included patients who received TAP block with general anesthesia; and Group S received spinal anesthesia. The study evaluated early and chronic postoperative pain, as well as pain severity, nature of the pain, predisposing factors, and the effect on various activities. No difference was found in pain incidence among the groups in the early postoperative pain evaluation; whereas VAS scores were lower in Group T. Chronic pain incidence was found to be lower in Group T. However, there was no difference among the groups in terms of VAS scores, pain nature, frequency, its effect on daily activities and sleep for patients with chronic pain. The TAP block is an effective method to prevent chronic pain development after inguinal hernioplasty compared to the other two methods. Because of the retrospective nature of the study, further prospective clinical trials are required.
  • Küçük Resim Yok
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    The Effect of Transversus Abdominis Plane Block in Inguinal Hernioplasty on Chronic Pain
    (Modestum Ltd, 2015) Topal, Ahmet; Sargin, Mehmet; Kilicaslan, Alper; Uzun, Sema Tuncer
    The aim of the current study was to retrospectively evaluate the efficacy of IV analgesia after general anesthesia, transversus abdominis plane (TAP) block after the induction of general anesthesia and before the surgery and spinal analgesia on development of chronic pain following inguinal hernia repair. Forty patients, who underwent hernioplasty for the first-time and for whom at least 6 months had passed since the operation date were included in the study, were included in each group as follows: Group G received IV analgesia with general anesthesia; Group T included patients who received TAP block with general anesthesia; and Group S received spinal anesthesia. The study evaluated early and chronic postoperative pain, as well as pain severity, nature of the pain, predisposing factors, and the effect on various activities. No difference was found in pain incidence among the groups in the early postoperative pain evaluation; whereas VAS scores were lower in Group T. Chronic pain incidence was found to be lower in Group T. However, there was no difference among the groups in terms of VAS scores, pain nature, frequency, its effect on daily activities and sleep for patients with chronic pain. The TAP block is an effective method to prevent chronic pain development after inguinal hernioplasty compared to the other two methods. Because of the retrospective nature of the study, further prospective clinical trials are required.
  • Küçük Resim Yok
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    Effects of Bilateral Infraorbital-Supraorbital Nerve Block on Postoperative Pain Control and Drug Consumption in Rhinoplasty
    (Aves, 2021) Yilmaz, Resul; Arican, Sule; Hacibeyoglu, Gulcin; Uzun, Sema Tuncer
    Objective: Rhinoplasty is a common procedure performed in plastic surgery. Postoperative pain, edema, and periorbital ecchymosis are the most common acute complications of this surgical procedure. In this study, we aimed to evaluate the postoperative pain and analgesic consumption after rhinoplasty of patients who had bilateral supraorbital and infraorbital nerve block. Methods: Eighty-four patients who underwent rhinoplasty under general anesthesia, between 17 and 41 years of age, and who underwent intravenous patient-controlled morphine analgesia for postoperative analgesia were included in this study. The cases were divided into two groups: bilateral supra-infraorbital block with intravenous analgesic (Group B) and only intravenous analgesic (Group C). Demographic data, hemodynamic data, operation time, visual analog scale values, patient-controlled analgesia device data, complaints of nausea-vomiting, and antiemetic drug use were recorded. Results: The hemodynamic data of the cases included in this study were similar (P > .05). When compared with Group C, postoperative 1st, 6th, and 24th hour visual analog scale (VAS) scores were found to be significantly lower in Group B (P < .05). Morphine consumption at the end of the postoperative 24 hours was found to be significantly lower in Group B compared with Group C (P < .05). Conclusion: In this study, which cases undergoing bilateral supraorbital-infraorbital nerve block and IV morphine was used for postoperative analgesia after rhinoplasty, significant reductions were achieved in the postoperative VAS values and analgesic consumption of the cases where the block was used.
  • Küçük Resim Yok
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    The effects of sevoflurane anesthesia on hemodynamics and cerebral artery diameters in endovascular treatment of intracranial aneurysm: A pilot study
    (Turkish Assoc Trauma Emergency Surgery, 2021) Arican, Sule; Bakdik, Suleyman; Hacibeyoglu, Gulcin; Yilmaz, Resul; Koc, Osman; Tavlan, Aybars; Uzun, Sema Tuncer
    BACKGROUND: Cerebral autoregulation is a steady-state of cerebral blood flow despite major changes in arterial blood pressure. Inhalation anesthetics are cerebral vasodilators. In <1 MAC values, the net effect is a moderate decrease in cerebral blood flow and maintenance of responsiveness to carbon dioxide. This study aims to investigate the effects of steady-state sevoflurane anesthesia on hemodynamic and cerebral artery diameter measurements in patients undergoing flow diverter device placement under general anesthesia. METHODS: Forty-six patients aged 18-70 years who underwent flow diverter devices under general anesthesia were included in this study. Routine monitoring was performed on the patients. Mean arterial pressure (MAP) values were recorded. Internal carotid artery, middle cerebral artery and anterior cerebral artery diameter measurements were made from digital subtraction angiography (DSA) images of patients with anterior aneurysms. Baseline artery, right posterior cerebral artery and left posterior cerebral artery diameter measurements were made from DSA images of patients with posterior aneurysms. These measurements were recorded as preoperative measurements. The same measurements were made from the DSA images performed before the Flow diverter device placement procedure performed under steady-state sevoflurane anesthesia for the same patients. These measurements were recorded as peroperative measurements. RESULTS: The average age of the patients was 56.6 +/- 15.1. The MAP of the patients before induction was 76.28 +/- 5.13 mmHg, MAP after induction was 64.36 +/- 3.23 mmHg, and MAP during sevoflurane anesthesia was 68.26 +/- 4.30 mmHg, there was a statistically significant difference. There was a statistically significant difference between the preoperative and perioperative values of anterior cerebral artery diameters. There was a strong relationship between the MAP change percentage and the ICA diameter change percentage (p<0.001, p=-0.785) and a moderate relationship between the MCA diameter change percentage (p=0.033, p=-0.338). CONCLUSION: In patients undergoing flow diverter devices, <1 MAC sevoflurane has a hemodynamic effect and creates significant vasodilation in the cerebral artery diameters.
  • Küçük Resim Yok
    Öğe
    The effects of sevoflurane anesthesia on hemodynamics and cerebral artery diameters in endovascular treatment of intracranial aneurysm: A pilot study
    (Turkish Assoc Trauma Emergency Surgery, 2021) Arican, Sule; Bakdik, Suleyman; Hacibeyoglu, Gulcin; Yilmaz, Resul; Koc, Osman; Tavlan, Aybars; Uzun, Sema Tuncer
    BACKGROUND: Cerebral autoregulation is a steady-state of cerebral blood flow despite major changes in arterial blood pressure. Inhalation anesthetics are cerebral vasodilators. In <1 MAC values, the net effect is a moderate decrease in cerebral blood flow and maintenance of responsiveness to carbon dioxide. This study aims to investigate the effects of steady-state sevoflurane anesthesia on hemodynamic and cerebral artery diameter measurements in patients undergoing flow diverter device placement under general anesthesia. METHODS: Forty-six patients aged 18-70 years who underwent flow diverter devices under general anesthesia were included in this study. Routine monitoring was performed on the patients. Mean arterial pressure (MAP) values were recorded. Internal carotid artery, middle cerebral artery and anterior cerebral artery diameter measurements were made from digital subtraction angiography (DSA) images of patients with anterior aneurysms. Baseline artery, right posterior cerebral artery and left posterior cerebral artery diameter measurements were made from DSA images of patients with posterior aneurysms. These measurements were recorded as preoperative measurements. The same measurements were made from the DSA images performed before the Flow diverter device placement procedure performed under steady-state sevoflurane anesthesia for the same patients. These measurements were recorded as peroperative measurements. RESULTS: The average age of the patients was 56.6 +/- 15.1. The MAP of the patients before induction was 76.28 +/- 5.13 mmHg, MAP after induction was 64.36 +/- 3.23 mmHg, and MAP during sevoflurane anesthesia was 68.26 +/- 4.30 mmHg, there was a statistically significant difference. There was a statistically significant difference between the preoperative and perioperative values of anterior cerebral artery diameters. There was a strong relationship between the MAP change percentage and the ICA diameter change percentage (p<0.001, p=-0.785) and a moderate relationship between the MCA diameter change percentage (p=0.033, p=-0.338). CONCLUSION: In patients undergoing flow diverter devices, <1 MAC sevoflurane has a hemodynamic effect and creates significant vasodilation in the cerebral artery diameters.
  • Küçük Resim Yok
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    Evaluation of the efficacy of erector spinae plane block and intercostal nerve block in the postherpetic neuralgia
    (Kare Publ, 2020) Hacibeyoglu, Gulcin; Arican, Sule; Ulukaya, Sinan Oguzhan; Yilmaz, Resul; Reisli, Ruhiye; Uzun, Sema Tuncer
    Objectives: The aim of this study was to compare the efficacy of an intercostal nerve block, which has been used for many years in the treatment of postherpetic neuralgia, and the more recent alternative of an erector spinae plane (ESP) block. Methods: The records of 39 patients who were treated in the algology department for postherpetic neuralgia between May 1, 2015 and May 1, 2018 were evaluated retrospectively. Patients who received an intercostal nerve block constituted Group 1 and those who received an ESP block were categorized as Group 2. The change in numeric rating scale (NRS) and Leeds Assessment of Neuropathic Symptoms and Signs (LANSS) scores in the short term and in the long term were the primary results of the study. Results: The NRS, LANSS, and sleep interference scale (SIS) scores of the patients in Group 1 and Group 2 were found to be significantly lower at the 24th hour, week 4, and week 12 compared with the values obtained before block application. In Group 1, the scores recorded at week 4 and week 12 were significantly higher than the 24th hour values, whereas no difference was observed between these results in Group 2.There was no significant difference between the groups in the week 4 and week 12 scores. Similarly, no significant difference was observed in the NRS, LANSS, or SIS scores before the block application or at the 24th hour. However, the scores at week 4 and week 12 were significantly lower in Group 2 compared with Group 1. Conclusion: The results indicated that an ESP block significantly decreased neuropathic pain symptoms and the need for additional treatment in postherpetic neuralgia treatment in the long term.
  • Küçük Resim Yok
    Öğe
    Evaluation of the efficacy of erector spinae plane block and intercostal nerve block in the postherpetic neuralgia
    (Kare Publ, 2020) Hacibeyoglu, Gulcin; Arican, Sule; Ulukaya, Sinan Oguzhan; Yilmaz, Resul; Reisli, Ruhiye; Uzun, Sema Tuncer
    Objectives: The aim of this study was to compare the efficacy of an intercostal nerve block, which has been used for many years in the treatment of postherpetic neuralgia, and the more recent alternative of an erector spinae plane (ESP) block. Methods: The records of 39 patients who were treated in the algology department for postherpetic neuralgia between May 1, 2015 and May 1, 2018 were evaluated retrospectively. Patients who received an intercostal nerve block constituted Group 1 and those who received an ESP block were categorized as Group 2. The change in numeric rating scale (NRS) and Leeds Assessment of Neuropathic Symptoms and Signs (LANSS) scores in the short term and in the long term were the primary results of the study. Results: The NRS, LANSS, and sleep interference scale (SIS) scores of the patients in Group 1 and Group 2 were found to be significantly lower at the 24th hour, week 4, and week 12 compared with the values obtained before block application. In Group 1, the scores recorded at week 4 and week 12 were significantly higher than the 24th hour values, whereas no difference was observed between these results in Group 2.There was no significant difference between the groups in the week 4 and week 12 scores. Similarly, no significant difference was observed in the NRS, LANSS, or SIS scores before the block application or at the 24th hour. However, the scores at week 4 and week 12 were significantly lower in Group 2 compared with Group 1. Conclusion: The results indicated that an ESP block significantly decreased neuropathic pain symptoms and the need for additional treatment in postherpetic neuralgia treatment in the long term.
  • Küçük Resim Yok
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    Immunological mechanism of postherpetic neuralgia and effect of pregabalin treatment on the mechanism: a prospective single-arm observational study
    (Korean Pain Soc, 2021) Mercan, Aysel; Uzun, Sema Tuncer; Keles, Sevgi; Hacibeyoglu, Gulcin; Yilmaz, Resul; Reisli, Ruhiye
    Background: Although neuropathic pain is a severe and common pain, its pathophysiology has not been elucidated yet. Studies in recent years have focused on the immune system's role in the pathogenesis of neuropathic pain. The aim of this study was to investigate the role of immunological mechanisms in neuropathic pain and the effect of pregabalin by measuring immunological marker levels in peripheral blood before and after pregabalin treatment in postherpetic neuralgia (PHN) patients with neuropathic pain. Methods: Forty patients diagnosed with PHN were included in the study. CD4, T follicular cells (If h: CD4(+)CXCR5(+)PD1(+)), Th17 (CD4(+)CCR6(+) and CD4(+)IL17A(+)), regulatory T cells (Treg: CD4(+)CD25(+)foxp3(+)), Th1 (CD4(+) CXCR3(+) and CD4(+ )IFN-gamma(+)) and Th2 (CD4(+) IL-4(+)) cell ratios were measured in peripheral blood samples before treatment and after 3 months of treatment. Results: When immunological marker and inflammation parameter levels were compared before and after treatment, the helper T cell ratio (CD3(+), CD4(+)) was 30.28 +/- 12.27% before treatment and 34.93 +/- 11.70% after treatment, so there was a statistically significant increase (P = 0.028). Th17 was 4.75 +/- 5.02% before treatment and 5.80 +/- 3.13% after treatment, and there was a statistically significant increase (P = 0.036). Conclusions: Immunological mechanisms play an essential role in the pathogenesis of neuropathic pain, immunologically based treatment approach will be the critical point of treatment.
  • Küçük Resim Yok
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    Investigation of the effect of ultrasonography-guided bilateral erector spinae plane block on postoperative opioid consumption and pain scores in patients undergoing hepatectomy: a prospective, randomized, controlled study
    (Associacao Paulista Medicina, 2022) Hacibeyoglu, Gulcin; Topal, Ahmet; Kucukkartallar, Tevfik; Yilmaz, Resul; Arican, Sule; Uzun, Sema Tuncer
    BACKGROUND: There is still a debate about what constitutes effective and safe postoperative analgesia in hepatectomy surgery. Erector spinae plane (ESP) block may be an important part of multimodal analgesia application in hepatectomy surgery. OBJECTIVES: To compare the effects of ultrasound-guided bilateral erector spinae plane block combined with intravenous (iv) patient-controlled analgesia (iv PCA), in comparison with iv PCA alone, in hepatectomy surgery. DESIGN AND SETTINGS: Randomized prospective single-blinded study in a tertiary university hospital. METHODS: Fifty patients scheduled for elective hepatectomy surgery were included in the study. Patients were randomized into the ESP group or the control group. In the ESP group, bilateral ESP block was performed preoperatively and iv PCA was used. In the control group, only iv PCA was used. Numerical rating scale (NRS) scores at rest and coughing, analgesic requirements and occurrences of nausea and vomiting were recorded. RESULTS: Intraoperative and postoperative opioid consumption, rescue analgesia requirement and resting and dynamic NRS scores were significantly lower in the ESP group (P < 0.05). There was no significant difference between two groups in terms of the presence of dynamic pain after the first postoperative hour. While all patients in the control group had nausea and vomiting, 24% of the patients in the ESP group did not have nausea and vomiting. CONCLUSION: This study showed that ESP block can be used as a part of multimodal analgesia, with the benefit of reducing opioid consumption and postoperative nausea and vomiting in hepatectomy surgery.
  • Küçük Resim Yok
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    Investigation of the effect of ultrasonography-guided bilateral erector spinae plane block on postoperative opioid consumption and pain scores in patients undergoing hepatectomy: a prospective, randomized, controlled study
    (Associacao Paulista Medicina, 2022) Hacibeyoglu, Gulcin; Topal, Ahmet; Kucukkartallar, Tevfik; Yilmaz, Resul; Arican, Sule; Uzun, Sema Tuncer
    BACKGROUND: There is still a debate about what constitutes effective and safe postoperative analgesia in hepatectomy surgery. Erector spinae plane (ESP) block may be an important part of multimodal analgesia application in hepatectomy surgery. OBJECTIVES: To compare the effects of ultrasound-guided bilateral erector spinae plane block combined with intravenous (iv) patient-controlled analgesia (iv PCA), in comparison with iv PCA alone, in hepatectomy surgery. DESIGN AND SETTINGS: Randomized prospective single-blinded study in a tertiary university hospital. METHODS: Fifty patients scheduled for elective hepatectomy surgery were included in the study. Patients were randomized into the ESP group or the control group. In the ESP group, bilateral ESP block was performed preoperatively and iv PCA was used. In the control group, only iv PCA was used. Numerical rating scale (NRS) scores at rest and coughing, analgesic requirements and occurrences of nausea and vomiting were recorded. RESULTS: Intraoperative and postoperative opioid consumption, rescue analgesia requirement and resting and dynamic NRS scores were significantly lower in the ESP group (P < 0.05). There was no significant difference between two groups in terms of the presence of dynamic pain after the first postoperative hour. While all patients in the control group had nausea and vomiting, 24% of the patients in the ESP group did not have nausea and vomiting. CONCLUSION: This study showed that ESP block can be used as a part of multimodal analgesia, with the benefit of reducing opioid consumption and postoperative nausea and vomiting in hepatectomy surgery.
  • Küçük Resim Yok
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    Ischemia-modified albumin (IMA) and dynamic thiol-disulfide homeostasis in patients with postherpetic neuralgia
    (Walter De Gruyter Gmbh, 2019) Arican, Sule; Hacibeyoglu, Gulcin; Ulukaya, Sinan Oguzhan; Avcioglu, Gamze; Reisli, Ruhiye; Uzun, Sema Tuncer; Erel, Ozcan
    Background: Ischemia-modified albumin (IMA) is an isotype of albumin that increases under oxidative stress, and plasma thiols are main defense mechanisms against oxidative stress. The objective of this study was to investigate thiol-disulfide homeostasis and serum IMA levels in postherpetic neuralgia (PHN) patients. Methods: A total of 29 PHN patients and 30 healthy controls were included in the study. Serum total and native thiol concentrations and serum disulfide concentration were measured using the method described by Erel and Neselioglu. The albumin cobalt binding test was used to measure serum IMA levels. Results: Serum IMA levels were 1.21 +/- 0.58 AU and 0.75 +/- 0.09 AU in the PHN and control groups, respectively (p <0.001). Serum total thiol concentrations were found to be 421.62 +/- 90.28 mu mol/L and 598.36 +/- 73.63 mu mol/L in the PHN and control groups, respectively (p <0.001). Serum native thiol concentrations were found to be 365.75 +/- 92.07 mu mol/L and 531.90 +/- 72.9 mu mol/L in the PHN and control groups, respectively (p < 0.001). Serum disulfide concentrations were found to be 33.23 +/- 5.33 mu mol/L and 27.93 +/- 7.81 mu mol/L in the PHN and control groups, respectively (p= 0.003). The native thiol/total thiol ratio was significantly lower, and the disulfide/total thiol and disulfide/native thiol ratios were significantly higher in the PHN group compared to the controls. Conclusions: IMA levels are high and dynamic thiol/disulfide homeostasis is disrupted in PHN patients.
  • Küçük Resim Yok
    Öğe
    Ischemia-modified albumin (IMA) and dynamic thiol-disulfide homeostasis in patients with postherpetic neuralgia
    (Walter De Gruyter Gmbh, 2019) Arican, Sule; Hacibeyoglu, Gulcin; Ulukaya, Sinan Oguzhan; Avcioglu, Gamze; Reisli, Ruhiye; Uzun, Sema Tuncer; Erel, Ozcan
    Background: Ischemia-modified albumin (IMA) is an isotype of albumin that increases under oxidative stress, and plasma thiols are main defense mechanisms against oxidative stress. The objective of this study was to investigate thiol-disulfide homeostasis and serum IMA levels in postherpetic neuralgia (PHN) patients. Methods: A total of 29 PHN patients and 30 healthy controls were included in the study. Serum total and native thiol concentrations and serum disulfide concentration were measured using the method described by Erel and Neselioglu. The albumin cobalt binding test was used to measure serum IMA levels. Results: Serum IMA levels were 1.21 +/- 0.58 AU and 0.75 +/- 0.09 AU in the PHN and control groups, respectively (p <0.001). Serum total thiol concentrations were found to be 421.62 +/- 90.28 mu mol/L and 598.36 +/- 73.63 mu mol/L in the PHN and control groups, respectively (p <0.001). Serum native thiol concentrations were found to be 365.75 +/- 92.07 mu mol/L and 531.90 +/- 72.9 mu mol/L in the PHN and control groups, respectively (p < 0.001). Serum disulfide concentrations were found to be 33.23 +/- 5.33 mu mol/L and 27.93 +/- 7.81 mu mol/L in the PHN and control groups, respectively (p= 0.003). The native thiol/total thiol ratio was significantly lower, and the disulfide/total thiol and disulfide/native thiol ratios were significantly higher in the PHN group compared to the controls. Conclusions: IMA levels are high and dynamic thiol/disulfide homeostasis is disrupted in PHN patients.
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    Neuromuscular Characteristics of Rocuronium in Diabetic Patients
    (Cukurova Univ, Fac Medicine, 2014) Topal, Ahmet; Sargin, Mehmet; Et, Tayfun; Uzun, Sema Tuncer
    Purpose: In diabetic patients, there may be obsserved functional loss of motor nerve fibers and this fact may affect the management of anesthesia in many ways. In our study we aimed to research if there is any differences between nondiabetic patients and the patients who have type 2 diabetes on the side of nueromuscular blockade characteristics of rocuronium. Material and Methods: 18 diabetic and 21 non-diabetic patients included to study, each patient evaluated by the NMT device after administiration of 0,6 mg/kg rocuronium intravenously. The onset of action time, clinical acting time, recovery time, total rocuronium dosage for each patient, amplitude of supramaximal excitation and Goldberg score were compared in the two groups. Results: Time of action (118,33 +/- 41,61 sn. & 142,00 +/- 28,68 sn.) and recovery time (13,33 +/- 9,83 dak. & 22,38 +/- 11,64 dak.) were longer than in diabetic patients (p<0,05), time of action and amplitude of supramaximal excitation were similar in two groups (p>0,05). Conclusion: We consider that the prolongation of onset of action time and recovery time in diabetic patients, is a complicaiton of diabetic neuropathy and diabetes may effect the pharmacodynamics of rocuronium.
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    Peripheral nerve blocks in a patient with suspected COVID-19 infection
    (Elsevier Science Inc, 2020) Kilicaslan, Alper; Kekec, Ahmet Fevzi; Eren, Ayse Seda; Uzun, Sema Tuncer
    [Abstract Not Availabe]
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    The place of ultrasonography in confirming the position of the laryngeal mask airway in pediatric patients: an observational study
    (Elsevier Science Inc, 2021) Arican, Sule; Pekcan, Sevgi; Hacibeyoglu, Gulcin; Yusifov, Merve; Yuce, Sait; Uzun, Sema Tuncer
    Background and objectives: Laryngeal mask airways are increasingly used as supraglottic devices during general anesthesia. Ultrasonography can provide a dynamic image simultaneous to placing the supraglottic airway device. In the current study, the incidence of suboptimal laryngeal mask airway position and replacement in children was evaluated using simultaneous ultrasonographic imaging. Methods: A prospective observational study was conducted on 82 patients aged 3-15 years with American Society of Anesthesiologists (ASA) physical status I or II. Patients under general anesthesia and with airway provided by a laryngeal mask airway were included. The position of the laryngeal mask airway was evaluated by ultrasonography on two planes. According to our scoring system, Grade I and Grade II were determined to indicate acceptable placement, while Grade III was determined to indicate unacceptable placement. Suboptimal laryngeal mask airway placement rates and the requirement of replacement were determined. Laryngeal mask airway placement optimized by ultrasonography was evaluated with both leak tests and a fiberoptic laryngoscope. Results: The average age of the patients was 6.27 +/- 4.66 years. After evaluation with ultrasonography, 65 (79.3%) of the laryngeal mask airways were found to be optimally positioned, while the position of 13 (15.9%) had to be corrected, and 4 (4.9%) had to be replaced. There was a moderate positive correlation between the ultrasonographic evaluation and leak test evaluation (p < 0.001; r = 0.628). Relocation of the laryngeal mask airway was determined to be an independent risk factor affecting the development of complications (OR = 2.961; p = 0.046; 95% Cl 2.850-30.745). Conclusion: The use of ultrasonography to verify and relocate laryngeal mask airway placement is noninvasive and effective. (c) 2021 Sociedade Brasileira de Anestesiologia. Published by Elsevier Editora Ltda. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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