Yazar "Vatansev, Celalettin" seçeneğine göre listele
Listeleniyor 1 - 11 / 11
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Clinicopathological Characteristics of Gastroenteropancreatic Neuroendocrine Tumors 10 Years of Experience From a Single Center(Lippincott Williams & Wilkins, 2022) Senturk, Mustafa; Acar, Berkan; Yildirim, Mehmet Aykut; Cakir, Murat; Kucukkartallar, Tevfik; Vatansev, CelalettinObjectives Gastorenteropancreatic neuroendocrine (GEP-NET) tumors are the second most common tumors of the gastrointestinal tract. We aimed to investigate the clinicopathological features and factors affecting the prognosis of patients with GEP-NET. Methods Clinicopathological features of 158 patients were evaluated, including tumor location, TNM stage and grade, pathological features, presence of lymph nodes and distant metastases at the time of diagnosis, maximum tumor diameter and treatment details. Also, follow-up information was analyzed to discover possible prognostic factors. Results The most common primary site is pancreas (45.6%, n = 72). Most of the GEP-NETs were nonfunctional (93.6%, n = 148). Of the 158 patients, 94 (59.5%) were grade 1, 46 (29.1%) grade 2, and 18 (11.4%) grade 3. The 1-year, 3-year, and 5-year survival rates were 82.3% (130/158), 61.4% (70/114), and 47.2% (35/74), respectively. In multivariate analysis, histological grade (P = 0.04) and TNM stage (P < 0.001) were independent prognostic factors for survival in patients with GEP-NET. Conclusions They are increasing in frequency and are the most common tumors in the pancreas. Nonfunctional tumors made up the majority of cases. The main treatment was surgical resection. Histological grade and TNM stage are independent prognostic factors.Öğe Effects of Tumor Volume on Lymph Node Involvement and Prognosis at Stage pt3 Colon Cancers(Springer India, 2022) Senturk, Mustafa; Ozer, Halil; Celik, Abdulkadir; Yildirim, Mehmet Aykut; Cakir, Murat; Vatansev, CelalettinSome studies showed that the increase of tumor size has a negative effect on survival in colon cancers. Our study aims to assess the effects of tumor volume on lymph node positivity and prognosis in stage pT3 colon cancers. All patients who underwent surgery for colon cancer in our clinic were evaluated retrospectively. The study included 213 patients who were diagnosed with colon adenocarcinoma and reported as pathologic. Preoperative abdomen computed tomography scans were used for measurements of tumor volume. Tumor volumes were compared according to the pathological lymph node involvement. Cut-off values were determined with ROC analysis. The cases were divided into groups according to the determined cut-off value and data compared. Mean tumor volume was found to be higher in the lymph node-positive group (p=0.01). The higher number of removed lymph nodes and lymph node positivity was detected more in cases that were above the cut-off value (p=0.003 and p=0.004, respectively). The mean survival time was 37.3 +/- 1.3 months. There was no correlation between tumor volume and the overall survival time (p=0.21). According to data comparison of the lymph node positivity, Kaplan-Meier analysis showed that the increase of the N stage reduces the 5-year survival rate (for the N0, N1, N2 stages, 60%, 52%, 35%, respectively). Tumor volume is correlated with lymph node involvement. It has been shown that increasing the N stage has a negative effect on prognosis. Our study showed that tumor volume has no significant impact on survival but may have an indirect effect on prognosis.Öğe Erkek Memesinin İnvaziv Papiller Karsinomu(2016) Gündeş, Ebubekir; Aksoy, Faruk; Vatansev, Celalettin; Esen, Hacı Hasan; Bal, AliMeme kanseri erkeklerde oldukça nadir görülür. Erkekte, kadın meme kanserlerinin tüm histolojik tipleri görülebilir. İnvaziv papiller karsinom ise nadir görülen bir meme kanseri tipidir. Memenin invaziv papiller karsinomu nedeniyle modifiye radikal mastektomi yapılan 67 yaşında bir erkek hastayı sunduk. Sağ memesinde ağrısız kitle yakınması ile kliniğimize başvurdu. Görüntüleme eşliğinde tru-cut biyopsi yapıldı. Biyopsi sonrası patolojik bulgular invaziv papiller karsinom ile uyumluydu. Modifiye radikal mastektomi işelemi uygulandı. 24 aylık takiplerinde nüks saptanmadı.Öğe The Increase of Intra-Abdominal Pressure Can Affect Intraocular Pressure(Hindawi Ltd, 2015) Ece, Ilhan; Vatansev, Celalettin; Kucukkartallar, Tevfik; Tekin, Ahmet; Kartal, Adil; Okka, AndmehmetObjective. This study aims to explore the usage of intraocular pressure measurements as the early indicator of the increase in intra-abdominal pressure. Methods. In this prospective study, 40 patients undergoing elective surgery were included. Patients were divided into four groups of 10 patients. The control group (Group C) was not subjected to laparoscopic intervention. Laparoscopic surgery was, respectively, performed with an intra-abdominal pressure of 9, 12, and 15 mmHg in Groups L (low), M (medium), and H (high pressure). Intraocular pressure was measured binocularly in each patient at three different times (before, during, and end of surgery) using a contact tonometer. Results. Patients' gender, age, body mass index (BMI), American Society of Anesthesiology (ASA) class, and operative times were not different among the groups. No complications occurred with either the surgery or measurement of intraocular pressure. Intubation was associated with a severe rise in IOP (P < 0.05). An increase in intraocular pressure was seen in groups M and H (P < 0.05). Conclusion. Intraocular pressure was increased in the groups with an intra-abdominal pressure of 12 mmHg or more. Measuring the intraocular pressure might be a useful method to estimate the intra-abdominal pressure.Öğe Invasive papillary carcinoma of the male breast(Yerkure Tanitim & Yayincilik Hizmetleri A S, 2016) Gundes, Ebubekir; Aksoy, Faruk; Vatansev, Celalettin; Esen, Haci Hasan; Bal, AliBreast cancer is rarely seen in male patients. All the histological types of female breast cancer can be seen in male patients. Invasive papillary carcinoma is a rare breast cancer type. We hereby report the case of a 67-year-old male patient who underwent modified radical mastectomy because of invasive papillary carcinoma. The patient presented to our clinic with the complaint of a painless mass in his right breast. Tru-cut biopsy guided by imaging was performed. The pathological results of the biopsy were in line with invasive papillary carcinoma. We performed modified radical mastectomy on the patient. No recurrences were seen in the 24-month follow-up period.Öğe Memenin granüler hücreli tümörü: Olgu sunumu(2013) Gündeş, Ebubekir; Aksoy, Faruk; Kozacıoğlu, Sümeyye; Vatansev, CelalettinMemenin granüler hücreli tümörü Schwann hücrelerinden köken alan nadir bir tümördür. Memede görülme oranı tüm granüler hücreli tümörlerin 5-8'i kadardır. Memenin granüler hücreli tümörü saptanan 61 yaşında bir kadın hastayı sunmak istedik.Öğe Primary Neuroendocrine Carcinoma of the Breast: A Report of Three Cases(2014) Aksoy, Faruk; Gündeş, Ebubekir; Vatansev, Celalettin; Çakır, Murat; Toy, Hatice; Emlik, Ganime DilekPrimary neuroendocrine carcinoma of the breast is extremely rare. More than 97% of neuroendocrine tumors occur in the gastrointestinal and respiratory tracts. Three cases that have been operated in our clinic and had a diagnosis of primary neuroendocrine carcinoma of the breast were assessed, along with literature data. Histopathological diagnoses were obtained by preoperative core needle biopsy. Breast-conserving surgery was performed in two cases, and modified radical mastectomy in one. In all cases, immunohistochemical studies were positive for neuron-specific enolase and synaptophysin. All patients received adjuvant chemotherapy (CT) and one patient received additional radiotherapy (RT). Recurrence or distant metastasis was not detected during long-term follow-up after surgery.Öğe Pure and Mixed Mucinous Carcinoma of the Breast(2013) Gündeş, Ebubekir; Aksoy, Faruk; Vatansev, Celalettin; Çakır, MuratAmaç: Müsinöz meme kanserleri nispeten nadirdir ve pür halinin tüm meme karsinomları içerisinde görülme sıklığı %2’dir. Pür ve mikst tipleri tarif edilmiştir. Bu çalışmada müsinöz meme kanserindeki tedavi yaklaşım- ları ve prognostik özelliklerin değerlendirilmesi amaçlanmıştır. Yöntem ve Gereçler: Bu çalışmada kliniğimizde 2004-2011 yılları ara- sında müsinöz meme kanseri nedeniyle ameliyat edilen 24 olgu patolojik tanılarına göre pür ve miks olarak iki gruba ayrıldı. Bulgular: Olguların tamamı bayan ve ortanca yaşı 54(37-84) idi. Miks müsinöz meme karsinomlu hasta sayısı 15 (%62.5), pür müsinöz meme karsinomlu hasta sayısı ise dokuz (%37,5) idi. Hastaların ortanca izlem süresi 40 (12-84) aydı. Pür grupta aksiller lenf nodu metastazı sadece bir (%11) olguda mevcut olup miks grupta ise dokuz olguda saptanmış olup istatistiksel olarak anlamlı fark vardı (p0,001). Sadece miks grupta bir has- tada lokal nüks görüldü. Miks grupta uzak metastazı olan hasta sayısı altı iken, pür grupta uzak metastaz saptanmadı. İki grup arasında uzak metastaz gelişimi açısından anlamlı fark vardı (p0,028). Sonuç: Pür müsinöz meme kanserlerinin diğer invaziv meme kanserlerine göre prognozu oldukça iyidir. Pür müsinöz meme karsinomları onkolojik prensiplere uyularak yapılan tedaviyle yüz güldürücü neticeler alınabilen bir kanser türüdür.Öğe Streptozotosinle oluşturulan diabete deneysel nesidioblastozisin etkisi(Necmettin Erbakan Üniversitesi Meram Tıp Fakültesi, 1995) Vatansev, Celalettin; Kartal, AdilKırk özel tip rata 40 ml/kg/gün(4 gün süreli) intraperitoneal streptozotosin verilerek tümünde deneysel diabet oluşturuldu. Diabetin oluştuğu klinik bulgu, açlık kan şekeri, idrar şekeri ve plazma insulin değerleri ile gösterildi. Diabetik hayvanlar 10 ar deneklik 4 guruba ayrıldı. I. Gruba( Kontrol grubu ) sham ameliyatı yapıldı. II. Grubta pankreas baş düzeyinde polipropilen ile, IH. Grubta pankreas baş düzeyinde krome katgüt ile, IV. Grubta pankreas baş düzeyinde polisülfonla sarıldı. Üçüncü haftanın sonunda kontrol grubunda 1(%14), II. grupta 3(%43), in.grupta 2(%40), IV.grupta 2(%33) denekte düzelme görüldü. Diabetleri düzeldi. Bu düzelme klinik ve laboratuvar olarak kanıtlandı. Düzelen denekler kilo aldı. AKŞ, idrar şekerleri ve plazma insulin değerleri normal seviyelere geldi. Klinik ve laboratuvar bulguları, histolojik olarak net bir şekilde desteklenemedi. Bu durum metodolojideki aksamalara bağlandı. Sonuçta deneysel nesidioblastozis hayvandaki pankreas ve materyale spesifik değildir. Hamster yerine rat, selofan yerine polipropilen, polisülfon gibi sarma materyalinin de kullanılabileceği kanısına varıldı.Öğe SURGICAL TREATMENT OF PHYLLODES TUMORS OF THE BREAST: A SINGLE CENTER EXPERIENCE(Aves, 2013) Aksoy, Faruk; Gundes, Ebubekir; Vatansev, Celalettin; Emlik, Ganime Dilek; Dogan, SerhatObjective: Phyllodes tumor of the breast is a rare fibroepithelial tumor. In this study, our aim is to present the clinicopathological characteristics of our patients diagnosed with phyllodes tumor of the breast and our treatment approach to the cases. Materials and Methods: The medical records of a total of 9 patients who had been treated at our clinic between 2003 and 2011 for phyllodes tumor were analyzed retrospectively. Results: The median age of the patients was 38 (20-70) years. The presenting complaint of all patients was a palpable mass in the breast. Six of the patients were diagnosed by tru-cut biopsy, two were diagnosed through excisional biopsy, and one was diagnosed through fine-needle aspiration biopsy (FNAB). Median tumor size was 9.3 (4-20) cm. Local excision was performed on all but two patients so as to have the surgical border negative and no adjuvant additional treatment was initiated. Mastectomy was performed for one of the two patients and modified radical mastectomy was performed for the other. The follow-up period of the patients was an average of 43 (5-95) months. No breast recurrences were seen during the follow-up period. Conclusion: Pre-operative diagnosis is important for these cases in order to determine the surgical approach. It is difficult to differentiate these tumors from fibroadenoma by ultrasonography and mammography. It is possible to diagnose patients through tissue biopsy. In conclusion, a surgical approach with negative margins for all patients should be taken into consideration since phyllodes tumors are generally benign both clinically and pathologically.Öğe Surgical treatment of phyllodes tumors of the breast: A single center experience(2013) Aksoy, Faruk; Gündeş, Ebubekir; Vatansev, Celalettin; Emlik, Ganime Dilek; Doğan, SerhatAmaç: Memenin fillodes tümörü nadir görülen fibroepitelyal bir tümördür. Bu çalışmada memenin fillodes tümörü tanılı hastalarımızın klinikopatolojik bulgularını ve tedavi yaklaşımımızı sunmayı amaçladık. Yöntem ve Gereçler: Kliniğimizde 2003-2011 yılları arasında memenin fillodes tümörü nedeniyle tedavi gören 9 hastanın tıbbi kayıtları geriye dönük olarak incelendi. Bulgular: Hastaların ortanca yaşı 38 (20-70) yaş olarak saptanmıştır. Hastaların tümünün başvuru şikayeti memede ele gelen kitle idi. Hastalardan altısına kalın-iğne biyopsi, ikisine eksizyonel biyopsi, birine de ince iğne aspirasyon biyopsisi (İİAB) ile tanı konuldu. Ortalama tümör büyüklüğü 9.3 (4-20) cm olarak hesaplandı. İki hasta dışında tüm olgulara cerrahi sınır negatif olacak şekilde lokal eksizyon uygulandı ve adjuvan ek bir tedavi verilmedi. İki hastadan birine mastektomi, diğerine ise modifiye radikal mastektomi işlemi uygulandı. Hastalar ortalama 43 (5-95) ay takip edildi. Takip süresince hastalarda memede nüks saptanmadı. Sonuç: Bu olgularda preoperatif tanı cerrahi yaklaşımı belirlemek açısından önemlidir. Ayırıcı tanıda yapılan ultrasonografi ve mamografi gibi radyolojik tetkiklerde bu tümörleri fibroadenomdan ayırt etmek zordur. Doku biyopsisi ile tanıya gitmek mümkündür. Sonuç olarak, fillodes tümörler genellikle klinik ve patolojik olarak selim olduğundan tüm hastalarda sınır negatif olacak şekilde cerrahi yaklaşım düşünülmelidir.
