Peritoneum and omentum are natural reservoirs for chondrocytes of osteochondral autografts: A comparative animal study

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dc.authoridOnur Bilge: 0000-0002-2976-0172en_US
dc.contributor.authorBüyükdoğan, Kadir
dc.contributor.authorDoral, Mahmut Nedim
dc.contributor.authorBilge, Onur
dc.contributor.authorTurhan, Egemen
dc.contributor.authorHuri, Gazi
dc.contributor.authorSargon, Mustafa Fevzi
dc.date.accessioned2020-01-18T21:02:58Z
dc.date.available2020-01-18T21:02:58Z
dc.date.issued2016
dc.departmentNEÜ, Meram Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Ortopedi ve Travmatoloji Anabilim Dalıen_US
dc.descriptionWOS:000392918000010en_US
dc.descriptionPubMed ID:27717559en_US
dc.description.abstractObjective: The purpose of this study was to investigate the effects of the omentum, peritoneum, paratenon and skeletal muscle on the proliferation of the cartilage tissue using rabbit model as an in vivo culture medium. Methods: 6 months old forty-five New Zealand rabbits were randomized into omentum, peritoneum, muscle, and Achilles paratenon groups. Standard sized osteochondral grafts were harvested from right knees and immediately placed into the specified tissues. Control group was fresh cartilage at the end of follow-up. After five months, samples were collected and evaluated macroscopically by measuring their dimensions (vertical ¼ D1, horizontal ¼ D2, and depth ¼ D3) and volumes, and histologically by counting the chondrocyte number using camera lucida method. Results: Macroscopically, increase in mean values for D1 and D2 dimensions of specimens from paratenon and omentum compared to pretransplant dimensions was statistically significant (p < 0.05). Although, volume measurements were higher in omentum and peritoneum group compared to pretransplant dimensions, increase was not significant (p > 0.05). Histologically, mean chondrocyte count was 14.0 ± 0.6 in fresh articular cartilage. Mean chondrocyte counts were 14.4 ± 0.9 in omentum group, 15.4 ± 1.0 in peritoneum group, 9.7 ± 1.3 in muscle group and 9.2 ± 0.4 in Achilles paratenon group respectively. However, mean chondrocyte counts were higher in samples of omentum and peritoneum group compared to fresh articular cartilage, increase was not statistically significant (p > 0.05). Discussion: Transplantation of the cartilage grafts into mesothelium enhanced the chondrocyte counts and volumes compared with the pretransplant measurements. Mesothelium may have the potential to be used as an in vivo culture medium for osteochondral tissue growth.en_US
dc.identifier.citationBilge, O., Büyükdoğan, K., Doral, M. N., Turhan, E., Huri, G., Sargon, M. F. (2016). Peritoneum and omentum are natural reservoirs for chondrocytes of osteochondral autografts: A comparative animal study. Acta Orthopaedica Et Traumatologica Turcica, 50, 5, 539-543.en_US
dc.identifier.doi10.1016/j.aott.2016.08.003en_US
dc.identifier.endpage543en_US
dc.identifier.issn1017-995Xen_US
dc.identifier.issue5en_US
dc.identifier.pmid27717559en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage539en_US
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TWpFM05EVXlNZz09/peritoneum-and-omentum-are-natural-reservoirs-for-chondrocytes-of-osteochondral-autografts-a-comparative-animal-study
dc.identifier.urihttps://hdl.handle.net/20.500.12452/1389
dc.identifier.volume50en_US
dc.identifier.wosWOS:000392918000010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofActa Orthopaedica et Traumatologica Turcicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US]
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCerrahien_US
dc.subjectCartilage preservationen_US
dc.subjectMesotheliumen_US
dc.subjectChondrocyteen_US
dc.subjectKneeen_US
dc.titlePeritoneum and omentum are natural reservoirs for chondrocytes of osteochondral autografts: A comparative animal studyen_US
dc.typeArticleen_US

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