Assessment of Serum Galectin-3 Levels in Patients with Gestational Diabetes Mellitus

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dc.authoridEmine Gül Baldane: 0000-0002-4462-3598en_US
dc.contributor.authorBaldane, Süleyman
dc.contributor.authorÇelik, Murat
dc.contributor.authorKörez, Muslu Kazım
dc.contributor.authorBaldane, Emine Gül
dc.contributor.authorAbuşoğlu, Sedat
dc.contributor.authorÜnlü, Ali
dc.contributor.authorİpekçi, Süleyman
dc.contributor.authorKebapçılar, Levent
dc.date.accessioned2023-05-18T13:16:06Z
dc.date.available2023-05-18T13:16:06Z
dc.date.issued2023en_US
dc.departmentNEÜ, Meram Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Halk Sağlığı Anabilim Dalıen_US
dc.departmentNEÜ, Meram Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Anabilim Dalıen_US
dc.descriptionMakaleen_US
dc.descriptionWOS:000941436500004en_US
dc.description.abstractObjective: This study was aimed to compare serum galectin-3 (Gal-3) levels in gestational diabetes mellitus (GDM) and healthy pregnant women and to evaluate the relationship between insulin resistance parameters and serum Gal-3 levels. Materials and Methods: Fifty-nine pregnant women who were screened for GDM with oral glucose tolerance tests (OGTT) at the 24th-28th gestational weeks were included in the study. According to the results of OGTT, 34 pregnant women were included in the GDM group and 25 pregnant women were included in the control group. Results: Serum Gal-3 value was found to be similar in the GDM and control group (P < 0.471). However, there was a significant positive association between Gal-3 and fasting insulin (r = 0.509, P < 0.001) and homeostasis model assessment of insulin resistance (HOMA-IR) (r = 0.479, P < 0.001) in the whole pregnancies, and between Gal-3 levels and fasting insulin (r = 0.608, P < 0.001), HOMA-IR (r = 0.609, P < 0.001), and OGTT 60 min glucose (r = 0.444, P = 0.016) in the GDM patients. Conclusions: There was no difference in the last trimester serum Gal-3 levels between GDM and healthy pregnant women. However, a significant positive correlation was determined between Gal-3 and fasting insulin, HOMA-IR, and OGTT 60 min glucose values in the GDM group, and fasting insulin and HOMA-IR values in whole pregnancies. The results of our study support previous data reporting the relationship between Gal-3 and GDM through insulin resistance.en_US
dc.description.sponsorshipScientific Research Projects (BAP) Coordination Unit of Selcuk Universityen_US
dc.identifier.citationBaldane, S., Çelik, M., Körez, M. K., Baldane, E. G., Abuşoğlu, S., Ünlü, A., İpekçi, S., Kebapçılar, L. (2023). Assessment of serum galectin-3 levels in patients with gestational diabetes mellitus. Journal of Diabetology, 14, 1, 28-33.en_US
dc.identifier.doi10.4103/jod.jod_84_22en_US
dc.identifier.endpage33en_US
dc.identifier.issn2543-3288en_US
dc.identifier.issn2078-7685en_US
dc.identifier.issue1en_US
dc.identifier.startpage28en_US
dc.identifier.urihttp://dx.doi.org/10.4103/jod.jod_84_22
dc.identifier.urihttps://hdl.handle.net/20.500.12452/9651
dc.identifier.volume14en_US
dc.identifier.wosWOS:000941436500004en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherMedknow Publicationsen_US
dc.relation.ispartofJournal of Diabetologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGalectin-3en_US
dc.subjectGestational Diabetes Mellitusen_US
dc.subjectSubclinical Inflammationen_US
dc.titleAssessment of Serum Galectin-3 Levels in Patients with Gestational Diabetes Mellitusen_US
dc.typeArticleen_US

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