Serum soluble TWEAK levels in non-alcoholic fatty liver disease
Yükleniyor...
Tarih
2019
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Aim: Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease. The exact pathogenesis of NAFLD has not been fully elucidated. Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) is a member of TNF superfamily and it hasbeen implicated in the pathogenesis of several diseases including liver inflammation and fibrosis. Current study was conducted to evaluate serum sTWEAK levels in patients with NAFLD. Material and Methods: Seventeen patients with biopsy proven non-alcoholic steatohepatitis (NASH), 22 patients with simple hepatosteatosis and 30 healthy controls were included in the study and serum sTWEAK concentrations were measured using commercial ELISA kits. Results: Mean serum sTWEAK concentration was significantly lower in the NASH group when compared to the simple hepatosteatosis group and healthy controls (199.6101.2 pg/mL, 246.165.7 pg/mL and 277.6117.6 pg/mL respectively, p0.029). ROC analysesfor sTWEAK to differentiate NASH patients from healthy controls and from simple hepatosteatosis revealed that AUC for sTWEAK was 0.712 (%95 CI, 0.543-0.880). For the specified cut off value, 171.1 pg/mL positive and negative predictive values calculated were 64.3% and 85.5% respectively. Conclusion: Serum sTWEAK concentration is decreased in patients with NASH when compared to patients with simple hepatosteatosis and healthy controls.
Açıklama
Anahtar Kelimeler
Nonalcoholic steatohepatitis, Tumor necrosis factor-like weak inducer of apoptosis, sTWEAK, Fibroblast growth factor-inducible 14, Fn 14
Kaynak
Annals of Medical Research
WoS Q Değeri
Scopus Q Değeri
Cilt
26
Sayı
8
Künye
Dertli, R., Yolaçan, R., Keskin, M., Kayar, Y., Ataseven, H., Polat, H., Ünver, N., Demir, A., Asıl, M., Bıyık, M., Uysal, S. (2019). Serum soluble TWEAK levels in non-alcoholic fatty liver disease. Annals of Medical Research, 26, 8, 1594-1599.
