Gastrointestinal stromal tümörlerde prognozun belirlenmesinde preoperatif nötrofil lenfosit oranının etkisi
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Dosyalar
Tarih
2015
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Gastrointestinal stromal tümörlerin lokal etkileriyle immünsupresyonda rol oynadığı düşünülmektedir. İnflamasyonla ilişkili bazı kanserlerde tedavi öncesi nötrofil lenfosit oranındaki artış kötü prognozun göstergesi olarak kabul edilmektedir. Çalışmamızın amacı gastrointestinal stromal tümör hastalarında kan nötrofil lenfosit oranı ile hastalığın prognozunu değerlendirmektir. Gereç ve Yöntemler: Kliniğimizde primer gastrointestinal stromal tümör nedeniyle cerrahi uygulanan 78 hastanın verileri retrospektif olarak değerlendirildi. Hastaların operasyon öncesi periferik kandan bakılan nötrofil lenfosit oranları belirlendi. Nötrofil lenfosit oranı ile tümör riski ve prognoz arasındaki ilişki karşılaştırıldı. Verilerin değerlendirilmesinde Pearson korelasyon analizi ve ANOVA Welch testi kullanıldı. Bulgular: Preoperatif nötrofil lenfosit oranındaki artış patolojik olarak yüksek riskli gastrointestinal stromal tümör gruplarında anlamlıydı (p0,05). Preoperatif nötrofil lenfosit oranı yüksek olan hastaların sağkalımları düşüktü (r- 0,32, p0,009). Ayrıca nötrofil lenfosit oranı artışı ile tümör mitotik aktivitesi artışı benzerdi (r-0,364, p0,025). Sonuç: Gastrointestinal stromal tümörlerde preoperatif nötrofil lenfosit oranı yüksek riskli tümörlerin belirlenmesinde ve kötü prognozun göstergesi olarak kullanılabilecek bir parametredir.
Objective: Gastrointestinal stromal tumors are believed to play a role in immunosuppression with their local effect. In some cancers with associated inflammation, an increased pretreatment neutrophil lymphocyte ratio is considered as an indicator of poor prognosis. The aim of our study was to assess the relationship of increased blood neutrophil lymphocyte ratio with disease prognosis in patients with gastrointestinal stromal tumors. Material and Methods: The data of 78 patients who underwent surgery with the diagnosis of primary gastrointestinal stromal tumor in our clinic were evaluated retrospectively. The preoperative neutrophil lymphocyte ratio in the peripheral blood was determined. The neutrophil lymphocyte ratio and its relationship with tumor risk and prognosis were compared. The data were evaluated by Pearson's correlation analysis and the Welch ANOVA test. Results: The preoperative neutrophil lymphocyte ratio was significantly increased in the high-risk groups (p>0.05). An increased preoperative neutrophil lymphocyte ratio was associated with shorter survival (r-0.32, p0.009). In addition, an increase in the neutrophil lymphocyte ratio was associated with an increase in the mitotic activity of the tumor (r-0.364, p0.025). Conclusion: The preoperative neutrophil lymphocyte ratio in gastrointestinal stromal tumors can be used as an indicator of high-risk tumors and poor prognosis.
Objective: Gastrointestinal stromal tumors are believed to play a role in immunosuppression with their local effect. In some cancers with associated inflammation, an increased pretreatment neutrophil lymphocyte ratio is considered as an indicator of poor prognosis. The aim of our study was to assess the relationship of increased blood neutrophil lymphocyte ratio with disease prognosis in patients with gastrointestinal stromal tumors. Material and Methods: The data of 78 patients who underwent surgery with the diagnosis of primary gastrointestinal stromal tumor in our clinic were evaluated retrospectively. The preoperative neutrophil lymphocyte ratio in the peripheral blood was determined. The neutrophil lymphocyte ratio and its relationship with tumor risk and prognosis were compared. The data were evaluated by Pearson's correlation analysis and the Welch ANOVA test. Results: The preoperative neutrophil lymphocyte ratio was significantly increased in the high-risk groups (p>0.05). An increased preoperative neutrophil lymphocyte ratio was associated with shorter survival (r-0.32, p0.009). In addition, an increase in the neutrophil lymphocyte ratio was associated with an increase in the mitotic activity of the tumor (r-0.364, p0.025). Conclusion: The preoperative neutrophil lymphocyte ratio in gastrointestinal stromal tumors can be used as an indicator of high-risk tumors and poor prognosis.
Açıklama
Anahtar Kelimeler
Cerrahi, Gastrointestinal Stromal Tümör, Nötrofil Lenfosit Oranı, Prognoz, Gastrointestinal Stromal Tumor, Neutrophil Lymphocyte Ratio, Prognosis
Kaynak
Ulusal Cerrahi Dergisi
WoS Q Değeri
Scopus Q Değeri
Q3
Cilt
31
Sayı
2
Künye
Kargın, S., Çakır, M., Gündeş, E., Yavuz, Y., Esen, H. H., İyisoy, M. S. (2015). Necmettin Erbakan Üniversitesi, Meram Tıp Fakültesi. Gastrointestinal stromal tümörlerde prognozun belirlenmesinde preoperatif nötrofil lenfosit oranının etkisi. Ulusal Cerrahi Dergisi, 31, 2, 61 - 64.
