Saving the zone of stasis in burns with melatonin: an experimental study in rats

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dc.authoridMustafa Cihat Avunduk: 0000-0002-8709-8949en_US
dc.contributor.authorKayapınar, Muhammet
dc.contributor.authorSeyhan, Nevra
dc.contributor.authorAvunduk, Mustafa Cihat
dc.contributor.authorSavacı, Nedim
dc.date.accessioned2020-01-18T21:02:53Z
dc.date.available2020-01-18T21:02:53Z
dc.date.issued2015
dc.departmentNEÜ, Meram Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Plastik Cerrahi Anabilim Dalıen_US
dc.departmentNEÜ, Meram Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Tıbbi Patoloji Anabilim Dalıen_US
dc.descriptionWOS:000368269100001en_US
dc.descriptionPubMed ID:27054630en_US
dc.description.abstractBACKGROUND: Studies aimed at recovering the zone of stasis are one of the major issues of experimental burn studies. Many drugs including antithrombotics, anticoagulants, anti-inflammatories have been investigated experimentally for saving the zone of stasis. In this study, the effect of the systemic melatonin on the zone of stasis was evaluated.METHODS: Twenty Wistar Albino rats were used in the study. Rats were assigned to two groups (n10). The metal comb 1x2 cm in size was immersed in boiling water and held for 20 seconds on the back of the rats to create burn wounds.No treatment was given to the control group. Melatonin was given at a dose of 10 mg/kg/d by intraperitoneal injection in the treatment group for 7 days. Daily digital photographs of both groups were obtained. Total necrotic burn areas and the zone of stasis were assessed with Auto CAD and Visual Analyzing computer programs. At the end of one week, rats were sacrificed and skin biopsies were taken for histological examination. Edema, congestion, inflammatory infiltration, vascular proliferation and fibrosis were the parameters evaluated. Data were evaluated statistically by Chi-square test and Student-t test.RESULTS: When histopatologic data and the measured values for total necrotic areas and zone of stasis of the experimental group werecompared to control group, the results were statistically significant (p>0.05).CONCLUSION: According to the results of this study, melatonin is efficient in saving the zone of stasis in burnsen_US
dc.identifier.citationKayapınar, M., Seyhan, N., Avunduk, M. C., Savacı, N. (2015). Saving the zone of stasis in burns with melatonin: an experimental study in rats. Ulusal Travma Ve Acil Cerrahi Dergisi = Turkish Journal of Trauma & Emergency Surgery : Tjtes, 21, 6, 419-424.en_US
dc.identifier.doi10.5505/tjtes.2015.53059en_US
dc.identifier.endpage424en_US
dc.identifier.issn1306-696Xen_US
dc.identifier.issn1307-7945en_US
dc.identifier.issue6en_US
dc.identifier.pmid27054630en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage419en_US
dc.identifier.urihttp://app.trdizin.gov.tr/publication/paper/detail/TVRrM01EUTNOdz09
dc.identifier.urihttps://hdl.handle.net/20.500.12452/1337
dc.identifier.volume21en_US
dc.identifier.wosWOS:000368269100001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.relation.ispartofUlusal Travma ve Acil Cerrahi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US]
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCerrahien_US
dc.subjectBurn Modelen_US
dc.subjectMelatoninen_US
dc.subjectZone Of Stasisen_US
dc.subjectMelatoninen_US
dc.subjectStaz Zonuen_US
dc.subjectYanıken_US
dc.titleSaving the zone of stasis in burns with melatonin: an experimental study in ratsen_US
dc.typeArticleen_US

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