Prognostic Value of İnterferon-Gamma, İnterleukin-6, and Tumor Necrosis Factor-Alpha in The Radiation Response of Patients Diagnosed With Locally Advanced Non-Small-Cell Lung Cancer and Glioblastoma Multiforme

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dc.authoridMehmet Gürbilek: 0000-0002-6281-8807
dc.contributor.authorDeniz, Çiğdem Damla
dc.contributor.authorGürbilek, Mehmet
dc.contributor.authorMehmet, Koç
dc.date.accessioned2020-01-18T21:04:37Z
dc.date.available2020-01-18T21:04:37Z
dc.date.issued2018
dc.departmentNEÜ, Meram Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Anabilim Dalıen_US
dc.departmentNEÜ, Meram Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Radyasyon Onkolojisi Bölümü, Anabilim Dalıen_US
dc.descriptionWOS:000425902900020en_US
dc.descriptionPubMed ID:29479968en_US
dc.description.abstractBackground/aim: This study aimed to investigate the effect of chemoradiotherapy (CRT) on interferon-gamma, interleukin-6(IL-6), and tumor necrosis factor-alpha, which are critical markers of the clinical radiation response of patients with locallyadvanced non-small-cell lung cancer (NSCLC) and glioblastoma multiforme (GBM).Materials and methods: Thirty patients who were treated with CRT and 20 healthy controls were prospectively evaluated. Circulatinglevels of cytokines were measured by enzyme-linked immunosorbent assay procedure. Post-CRT and pre-CRT levels were compared.Results: Post-CRT, TNF- and IFN- levels were significantly lower than pre-CRT levels in the NSCLC and GBM groups, respectively.The statistical analysis did not show any significant difference between the post- and pre-CRT IL-6 levels. However, the pre-CRT IL-6levels in the GBM group and post-CRT IL-6 levels in the NSCLC group were significantly higher than those of the control group.Conclusion: CRT affected TNF- levels in NSCLC and IFN- levels in GBM, with the levels of both decreasing significantly. The IL-6levels of the post-CRT NSCLC group were higher than those of the post-CRT GBM group. Irradiation-induced IL-6 may be responsiblefor tumor regrowth. Therefore, treatment with IL-6 inhibitors could be a potential therapeutic strategy for sensitizing NSCLC toirradiation in the clinic.en_US
dc.identifier.citationDeniz, Ç. D., Gürbilek, M., Koç, M. (2018). Prognostic value of interferon-gamma, interleukin-6, and tumor necrosis factor-alpha in the radiation response of patients diagnosed with locally advanced non-small-cell lung cancer and glioblastoma multiforme. Turkish Journal of Medical Sciences, 48, 1, 117-123.en_US
dc.identifier.doi10.3906/sag-1611-77en_US
dc.identifier.endpage123en_US
dc.identifier.issn1300-0144en_US
dc.identifier.issn1303-6165en_US
dc.identifier.issue1en_US
dc.identifier.pmid29479968en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage117en_US
dc.identifier.urihttps://dx.doi.org/10.3906/sag-1611-77
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TWprNU1UVXlNZz09/prognostic-value-of-interferon-gamma-interleukin-6-and-tumor-necrosis-factor-alpha-in-the-radiation-response-of-patients-diagnosed-with-locally-advanced-non-small-cell-lung-cancer-and-glioblastoma-multiforme
dc.identifier.urihttps://hdl.handle.net/20.500.12452/1874
dc.identifier.volume48en_US
dc.identifier.wosWOS:000425902900020en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US]
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectInterferon-gammaen_US
dc.subjectİnterleukin-6en_US
dc.subjectTumor necrosis factor-alphaen_US
dc.subjectCanceren_US
dc.subjectRadiotherapyen_US
dc.titlePrognostic Value of İnterferon-Gamma, İnterleukin-6, and Tumor Necrosis Factor-Alpha in The Radiation Response of Patients Diagnosed With Locally Advanced Non-Small-Cell Lung Cancer and Glioblastoma Multiformeen_US
dc.typeArticleen_US

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