Karotid endarterektomi geçiren hastalarda kontrolsüz diyabetin statin kullanan ve kullanmayan hastalarda LDL seviyelerine etkisi
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Dosyalar
Tarih
2016
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Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Çalışmanın amacı Karotid endarterektomi geçiren hastalarda kontrolsüz diyabetes mellitusun (DM) uzun süreli statin kullanan ve kullanmayan hastalarda Düşük Yoğunluklu Lipoprotein (LDL) seviyelerine etkisini araştırmaktı.Gereç ve yöntem: Ateroskleroz nedeniyle karotid endarterektomi geçiren 40 hastanın ameliyat öncesi LDL seviyeleri retrospektif olarak analiz edildi. Tüm hastalar en az 1 yıldır statin kullanıyordu. HbA1C seviyelerinin % 6,4'den fazla olması kontrolsüz DM kriteri kabul edildi (D). Diğer hastalar diyabet olmayan gruplara alındı (D-). Grup 1: D statin kullanan (n9), grup 2: D- statin kullanan (n10), grup 3: D statin kullanmayan (n8), grup 4: D- statin kullanmayan (n13) hastalardan oluştu. İstatistiksel değerlendirme için Kruskal-Wallis ve Mann-Whitney testleri kullanıldı. p0,05 anlamlı kabul edildi.Bulgular: Demografik veriler benzerdi. Grup 1, 2, 3 ve 4 için LDL seviyeleri sırasıyla 125,08,7 mg/dl, 95,07,0 mg/dl, 133,510,0 mg/dl, 114,010,2 mg/dl olarak bulundu. ). Statin kullanan ve kullanmayan kontrolsüz diyabet hastalarının LDL seviyeleri diğer gruplardan anlamlı derecede yüksekti (p0,05). Statin kullanan diyabetik hastaların LDL seviyeleri de statin kullanan normal hastalardan daha yüksekti (p0,05). Kontrolsüz diyabet olan hastaların LDL seviyeleri statin kullanan ve kullanmayan gruplarda benzerdi (p0,05). Diyabet olmayan hastaların LDL seviyeleri benzer bulundu (p0,05).Sonuç: Bu çalışma, kontrolsüz diyabeti olan ateroskleroz hastalarının LDL seviyelerinin, statin kullansınlar ya da kullanmasınlar diyabet olmayan ateroskleroz hastalarından daha yüksek olduğunu göstermiştir. İleri çalışmaların kanıtlanmış aterosklerozu olan hasta gruplarında çok merkezli ve yüksek vaka sayılı olarak yapılmasının uygun olacağı görüşündeyiz.
Introduction: This study aims to assess the effects of uncontrolled diabetes mellitus (DM) on LDL levels of atherosclerotic patients on long term statins and patients not on statins.Material and Methods: LDL levels of 40 patients undergoing carotid endarterectomy due to atherosclerosis were retrospectively analyzed. All statin users were on statins for <1yr. Patients with HbA1C levels of <6.4% were considered as uncontrolled DM (D). All other patients were non diabetics (D-). Group1: D, statin user (n9), group 2: D- statin user (n10), group 3: D non statin user (n8), and group 4: D- non statin user (n13). LDL levels are given as mg/dl, Kruskal-Wallis and Mann-Whitney tests were used for statistics. p>0.05 significant.Results: Demographic data were similar. LDL levels for groups 1, 2, 3 and 4 were 125.0±8.7 mg/dl, 95.0±7.0 mg/dl, 133.5±10.0 mg/dl, 114.0±10.2 mg/dl respectively. LDL levels of uncontrolled diabetic patients on and off statins were significantly higher than normal patients (p>0.05). LDL levels were similar in both uncontrolled diabetic patient groups (p<0.05). LDL levels of non-diabetic patients on statins was similar to off statin non-diabetic patients (p<0.05). Conclusions: Results of this study suggest that atherosclerotic patients with uncontrolled diabetes who are either on or off statin therapy have higher LDL results compared to non-diabetic atherosclerotic patients. Further multicenter studies with higher number of patients with proven atherosclerosis are needed.
Introduction: This study aims to assess the effects of uncontrolled diabetes mellitus (DM) on LDL levels of atherosclerotic patients on long term statins and patients not on statins.Material and Methods: LDL levels of 40 patients undergoing carotid endarterectomy due to atherosclerosis were retrospectively analyzed. All statin users were on statins for <1yr. Patients with HbA1C levels of <6.4% were considered as uncontrolled DM (D). All other patients were non diabetics (D-). Group1: D, statin user (n9), group 2: D- statin user (n10), group 3: D non statin user (n8), and group 4: D- non statin user (n13). LDL levels are given as mg/dl, Kruskal-Wallis and Mann-Whitney tests were used for statistics. p>0.05 significant.Results: Demographic data were similar. LDL levels for groups 1, 2, 3 and 4 were 125.0±8.7 mg/dl, 95.0±7.0 mg/dl, 133.5±10.0 mg/dl, 114.0±10.2 mg/dl respectively. LDL levels of uncontrolled diabetic patients on and off statins were significantly higher than normal patients (p>0.05). LDL levels were similar in both uncontrolled diabetic patient groups (p<0.05). LDL levels of non-diabetic patients on statins was similar to off statin non-diabetic patients (p<0.05). Conclusions: Results of this study suggest that atherosclerotic patients with uncontrolled diabetes who are either on or off statin therapy have higher LDL results compared to non-diabetic atherosclerotic patients. Further multicenter studies with higher number of patients with proven atherosclerosis are needed.
Açıklama
Anahtar Kelimeler
Genel ve Dahili Tıp, Ateroskleroz, Statin, Karotid Endarterektomi, Ldl, Atherosclerosis, Statin, Carotid Endarterectomy
Kaynak
Genel Tıp Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
26
Sayı
2
Künye
Duman, i., Vatansev, H., Şimşek, M., Arun, O., Öç, B., Duman, A., Öç, M. A. (2016). Karotid Endarterektomi geçiren hastalarda kontrolsüz diyabetin statin kullanan ve kullanmayan hastalarda LDL seviyelerine etkisi. Genel Tip Dergisi, 26, 2, 50.
