Prediabetes and Cardiovascular Parameters in Obese Children and Adolescents

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dc.authorid0000-0002-2242-9401en_US
dc.contributor.authorEklioğlu, Beray Selver
dc.contributor.authorAtabek, Mehmet Emre
dc.contributor.authorAkyürek, Nesibe
dc.contributor.authorAlp, Hayrullah
dc.date.accessioned2020-01-18T21:02:57Z
dc.date.available2020-01-18T21:02:57Z
dc.date.issued2016
dc.departmentNEÜ, Meram Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalığı Anabilim Dalıen_US
dc.description.abstractObjective: In this study, our aim was to determine cardiovascular risk and cardiac function in prediabetic obese children and adolescents. Methods: The study was conducted on 198 obese children and adolescents 6-18 years of age. Anthropometric measurements, blood pressure measurements, oral glucose tolerance test, lipid profile, and HbA1c levels of patients were assessed. Prediabetes was defined according to American Diabetes Association criteria. Left ventricular mass index (LVMi), carotid intima-media thickness (c-IMT), and tissue Doppler measurements records were used.Results: LVMi was found to be significantly higher in the prediabetes group (p0.03). There were no statistically significant differences in right ventricular tissue Doppler measurements between the prediabetic and non-prediabetic groups. Left ventricular tissue Doppler measurements were significantly higher in the prediabetes group: LVEEM (left ventricular E/e ratio) (p0.04); LVEM (left ventricular myocardial velocity cm/s) (p0.035). LVMi was found to positively correlate with triglyceride level, diastolic blood pressure, waist circumference, body weight standard deviation score and to negatively correlate with high-density lipoprotein cholesterol (p0.043, r0.15; p0.039, r0.15; p0.025, r0.17; p0.009, r0.19; p0.038, r-0.15, respectively). LVEM was correlated with glucose (p0.046, r0.15) and LVEEM was correlated with systolic blood pressure (p0.035, r0.15). In linear regression analysis for clinical cardiovascular risk factors, fasting glucose level was the best predictor of LVEM.Conclusion: In this study, deterioration of cardiac function in prediabetic obese children and adolescents was shown. We recommend determining cardiovascular risk and cardiac dysfunction at early stages in prediabetic obese children and adolescents.en_US
dc.identifier.citationEklioğlu, B. S., Atabek, M. E., Akyürek, N., Alp, H. (2016). Prediabetes and cardiovascular parameters in obese children and adolescents. Jcrpe Journal of Clinical Research in Pediatric Endocrinology, 8, 1, 80-85.en_US
dc.identifier.doi10.4274/jcrpe.2248en_US
dc.identifier.endpage85en_US
dc.identifier.issn1308-5727en_US
dc.identifier.issn1308-5735en_US
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage80en_US
dc.identifier.urihttp://app.trdizin.gov.tr/publication/paper/detail/TVRrNU16UTBOQT09
dc.identifier.urihttps://hdl.handle.net/20.500.12452/1379
dc.identifier.volume8en_US
dc.identifier.wosWOS:000378168600012en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofJournal of Clinical Research in Pediatric Endocrinologyen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US]
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEndokrinoloji ve Metabolizmaen_US
dc.subjectPediatrien_US
dc.subjectObesityen_US
dc.subjectPrediabetesen_US
dc.subjectChildrenen_US
dc.subjectAdolescenten_US
dc.titlePrediabetes and Cardiovascular Parameters in Obese Children and Adolescentsen_US
dc.typeArticleen_US

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