Effects of Nigella sativa L. seed oil on intima-media thickness and Bax and Caspase 3 expression in diabetic rat aorta

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dc.authoridGökhan Cüce: 0000-0003-1781-5292
dc.authoridSabiha Serpil Kalkan: 9590
dc.authoridMehmet Enes Sözen: 0000-0002-5007-6631
dc.authoridHalime Tuba Canbaz: 0000-0003-4671-1249
dc.contributor.authorCüce, Gökhan
dc.contributor.authorKalkan, Sabiha Serpil
dc.contributor.authorSözen, Mehmet Enes
dc.contributor.authorÇetinkaya, Seda
dc.contributor.authorCanbaz, Halime Tuba
dc.contributor.authorSeflek, Hatice
dc.date.accessioned2020-01-18T21:02:57Z
dc.date.available2020-01-18T21:02:57Z
dc.date.issued2016
dc.departmentNEÜ, Meram Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Anabilim Dalıen_US
dc.description.abstractObjective: Hyperglycaemia is an important risk factor for the development and progression of the macrovascular and microvascular complications that occur in diabetes. The expression of apoptotic markers in the aortic medial layer of diabetic rats and the effects of N. sativa L. seed oil on the expression of these markers were investigated in this study. Methods: Four-month-old adult female Wistar rats (n21) were divided into 3 groups: Group 1, control; Group 2, diabetes and Group 3, diabetes+N. sativa L. seed oil. Group 3 received 0.2 mg/kg/day N. sativa L. seed (black cumin) oil intraperitoneally 6 days per week for 30 days. At the end of the experiment, abdominal and thoracic aortas of all animals were collected and fixed in 10% formalin solution. Then, 5-?m-thick sections were stained with Verhoeff-Van Gieson stain to evaluate Bax and Caspase 3 expression. Tunica intima-media thickness was measured using the stained sections. Results: There were no significant differences in abdominal or thoracic aortic intima-media thickness among the 3 groups. However, there were significant differences in Bax and Caspase 3 expression in the tunica media of the thoracic and abdominal aortas between Group 1 and Group 2 (p0.05) and between Group 2 and Group 3 (p0.05) evaluated with the Kruskal-Wallis and Mann-Whitney U tests.Conclusion: It is understood that N. sativa L. seed oil is effective against diabetes. N. sativa L. seed oil is a plant material and has value for further investigation to develop diabetes treatment strategies for preventing apoptosis in vascular structures.en_US
dc.identifier.citationCüce, G., Kalkan, S. S., Sözen, M. E., Çetinkaya, S., Canbaz, H. T., Seflek, H. (2016). Effects of Nigella sativa L. seed oil on intima-media thickness and Bax and Caspase 3 expression in diabetic rat aorta. The Anatolian Journal of Cardiology, 16, 7, 460-466.
dc.identifier.doi10.5152/AnatolJCardiol.2015.6326en_US
dc.identifier.endpage466en_US
dc.identifier.issn2149-2263en_US
dc.identifier.issn2149-2271en_US
dc.identifier.issue7en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage460en_US
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TWpVd056VTRPQT09/effects-of-nigella-sativa-l-seed-oil-on-intima-media-thickness-and-bax-and-caspase-3-expression-in-diabetic-rat-aorta
dc.identifier.urihttps://hdl.handle.net/20.500.12452/1378
dc.identifier.volume16en_US
dc.identifier.wosWOS:000384426300002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofThe Anatolian Journal of Cardiologyen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US]
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDiabetesen_US
dc.subjectAortaen_US
dc.subjectNigella sativa L. seed oilen_US
dc.subjectBaxen_US
dc.subjectCaspase 3en_US
dc.titleEffects of Nigella sativa L. seed oil on intima-media thickness and Bax and Caspase 3 expression in diabetic rat aortaen_US
dc.typeArticleen_US

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