Tip 1 Diabetes Mellituslu Hastaların Uzun Dönem İzlemi: Tek Merkez Deneyimi
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Tarih
2015
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Tip 1 diyabetes mellitus (DM) çocukluk yaş grubunda sık görülen, pankreasın beta hücrelerinin tahrip olması sonucu gelişen insülopeni ve hiperglisemi ile karakterize kronik metabolik bir hastalıktır. Çalışmada, Tip 1 DMli hastaların klinik ve laboratuvar bulgularının değerlendirilmesi ve bulguların literatür eşliğinde tartışılması amaçlanmıştır. Gereç ve Yöntemler: Bu çalışma 2010-2013 Ocak tarihleri arasında Pediatrik Endokrinoloji Kliniğinde takip edilen, Tip 1 DMli 162 hastanın değerlendirildiği tanımlayıcı kesitsel bir araştırmadır. Bulgular: Çalışmamıza 162 hasta dahil edildi (Yaş ortalaması 12.3 4.2 yıl). Olguların ortalama diyabet süresi 3.92.3 yıl, son 1 yıldaki ortalama Hba1c değerleri%9.74 2.5di. Tip 1 DMye ek olarak olguların % 6.7sinde (n11) çölyak hasta- lığı , %18.52inde (n30) de otoimmüntiroid hastalığı mevcuttu. Olguların %9.2sinde (n15) hipertansiyon, %7. 4ünde (n12) dislipidemi saptandı. Mikrovasküler komplikasyon olarak % 6.1inde (n10) 24 saatlik idrarda mikroalbüminüri, %15.4ünde (n25) EMGde sinir ileti hızında yavaşlama tespit edildi. Sonuç: Tip 1 DMli hastaların izleminde eşlik edebilecek otoimmün hastaların tespiti ve diyabete bağlı gelişebilecek komplikasyonların erken dönemde saptanması ve koruyucu önlemlerin alınması hastaların hayat kalitesinin arttırılması açısından önemlidir.
Objective: Type 1 diabetes mellitus (DM) is a chronic metabolic disease of childhood characterized by insulin insufficiency and hyperglycemia due to the destruction of the beta cells of the pancreas. The aim of this study was to determine the laboratory and clinical characteristics of patients with type 1 diabetes mellitus and to compare the findings with the literature. Material and Methods: This is a descriptive study of 162 patients with type 1 diabetes mellitus followed by the Pediatric Endocrinology department between January 2010 and 2013. results: A total of 162 patients were included in this study (mean age, 12. 3 ±4. 2 years). The mean duration of diabetes was 3.89 ± 2.3 years and mean HbA1c was 2.5 ± 9.74%. In addition to Type 1 DM, 6.7% of cases (n 11) had celiac disease and 18.52% of the cases (n 30) had autoimmune thyroid disease. Hypertension was present in 9.2% of the cases (n 15) while 7.4% (n 12) had dyslipidemia. We found had 24-hour urine microalbuminuria in 6.1% of the cases (n 10) and decreased EMG nerve conduction velocity in 15.4% of the cases (n 25). conclusion: It is important to detect any concurrent autoimmune disorders and diabetes-related potential complications in the early stages and to take preventive measures to increase the quality of life during follow-up of patients with Type 1 DM.
Objective: Type 1 diabetes mellitus (DM) is a chronic metabolic disease of childhood characterized by insulin insufficiency and hyperglycemia due to the destruction of the beta cells of the pancreas. The aim of this study was to determine the laboratory and clinical characteristics of patients with type 1 diabetes mellitus and to compare the findings with the literature. Material and Methods: This is a descriptive study of 162 patients with type 1 diabetes mellitus followed by the Pediatric Endocrinology department between January 2010 and 2013. results: A total of 162 patients were included in this study (mean age, 12. 3 ±4. 2 years). The mean duration of diabetes was 3.89 ± 2.3 years and mean HbA1c was 2.5 ± 9.74%. In addition to Type 1 DM, 6.7% of cases (n 11) had celiac disease and 18.52% of the cases (n 30) had autoimmune thyroid disease. Hypertension was present in 9.2% of the cases (n 15) while 7.4% (n 12) had dyslipidemia. We found had 24-hour urine microalbuminuria in 6.1% of the cases (n 10) and decreased EMG nerve conduction velocity in 15.4% of the cases (n 25). conclusion: It is important to detect any concurrent autoimmune disorders and diabetes-related potential complications in the early stages and to take preventive measures to increase the quality of life during follow-up of patients with Type 1 DM.
Açıklama
Anahtar Kelimeler
Mikrovasküler komplikasyon, Otoimmün hastalık, Tip 1 diyabetes mellitus, Microvascular complications, Autoimmune disease, Type 1 diabetes mellitus
Kaynak
Türkiye Çocuk Hastalıkları Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
9
Sayı
4
Künye
Atabek, M. E., Eklioğlu, B. S., Akyürek, N. (2015). Tip 1 Diabetes Mellitus'lu hastaların uzun dönem izlemi: Tek merkez deneyimi. Türkiye Çocuk Hastalıkları Dergisi, 9, 4, 243-247.
