Kistik Fibrozis Dışı Bronşiektazili Çocuk Hastalarda Oksidan ve Antioksidan Denge
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Tarih
2018
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Çocuklarda, oksidan ve antioksidan dengenin kistik fibrosis dışı bronşiekatazi (non-CF BE) patogenezi ve prognozundaki etkisinin değerlendirilmesi.Gereç ve Yöntem: Haziran 2009 ve Ekim 2010 tarihleri arasında nonCF BE tanılı 29 çocuk çalışmaya alındı. Otuz sağlıklı çocuk kontrol grubunu oluşturdu. Sağlıklı ve hasta çocuklarda paraoksonaz1 (PON1), total oksidan durum (TOS) ve total antioksidan durum (TAS) serum düzeyleri stabil ve alevlenme dönemlerinde ölçüldü.Bulgular: Hasta grubunda PON1 ve TAS düzeyleri alevlenme döneminde kontrol gurbuna göre daha düşüktü (p 0.05 ve p 0.01, sırasıyla). İmmün yetmezlikli hastalarda oksidatif stresi gösteren TOS düzeyleri ve TAS/TOS oranı kontrol grubuna göre daha düşüktü (p 0.008 ve p 0.01, sırasıyla). TAS düzeyleri ve PON1/TOS oranı orta-şiddetli bronşiektazili hastalarda hafif bronşektazili hastalardan daha düşüktü (p 0.04 ve p 0.03, sırasıyla).Sonuç: Alevlenme döneminde non-CF BE çocuklarda oksidatif stres artmış ve anti-oksidan kapasite azalmıştır. Antioksidan tedavi özellikle immün yetmezliği ve/veya orta-şiddetli bronşiaktazisi olan non-CF BE hastalarda oksidatif stresin neden olduğu hasarın şiddetini azaltmaya yardımcı olacak, özellikle daha iyi prognoza katkıda bulunacaktır.
Objective: To evaluate the role of the oxidant and antioxidant balance in the pathogenesis and prognosis of non-cystic fibrosis bronchiectasis (non-CF BE) in children.Materials and Methods: Twenty-nine children with non-CF BE were enrolled between June 2009 and October 2010. Thirty healthy children were enrolled as controls. Paraoxonase 1 (PON1), total oxidant status (TOS), and total antioxidant status (TAS) serum levels were measured in controls and in patients when stable and at acute exacerbation.Results: PON1 and TAS levels were lower in patients at acute exacerbation than in controls (P 0.05 and P 0.01, respectively). TOS levels indicative of oxidative stress were higher, and TAS/TOS levels were lower, in immune-deficient patients than control group (P 0.008 and P 0.01, respectively). TAS levels and PON1/TOS ratio were significantly lower in patients with moderate-severe bronchiectasis than in patients with mild bronchiectasis (P 0.043 and P 0.03, respectively).Conclusion: Oxidative stress was increased and antioxidant capacity decreased in patients with non-CF BE during the exacerbation period. Antioxidant treatment in patients with non-CF BE, especially in patients with immunodeficiency and/or with moderate-severe bronchiectasis, could be helpful to reduce the frequency and severity of the attacks by reducing oxidative stress-induced damage, ultimately contributing to a better prognosis.
Objective: To evaluate the role of the oxidant and antioxidant balance in the pathogenesis and prognosis of non-cystic fibrosis bronchiectasis (non-CF BE) in children.Materials and Methods: Twenty-nine children with non-CF BE were enrolled between June 2009 and October 2010. Thirty healthy children were enrolled as controls. Paraoxonase 1 (PON1), total oxidant status (TOS), and total antioxidant status (TAS) serum levels were measured in controls and in patients when stable and at acute exacerbation.Results: PON1 and TAS levels were lower in patients at acute exacerbation than in controls (P 0.05 and P 0.01, respectively). TOS levels indicative of oxidative stress were higher, and TAS/TOS levels were lower, in immune-deficient patients than control group (P 0.008 and P 0.01, respectively). TAS levels and PON1/TOS ratio were significantly lower in patients with moderate-severe bronchiectasis than in patients with mild bronchiectasis (P 0.043 and P 0.03, respectively).Conclusion: Oxidative stress was increased and antioxidant capacity decreased in patients with non-CF BE during the exacerbation period. Antioxidant treatment in patients with non-CF BE, especially in patients with immunodeficiency and/or with moderate-severe bronchiectasis, could be helpful to reduce the frequency and severity of the attacks by reducing oxidative stress-induced damage, ultimately contributing to a better prognosis.
Açıklama
Anahtar Kelimeler
Çocuk, Kistik fibrosis dışı bronşiektazi, Oksidatif denge, Paraoksonaz, Children, Non-cystic fibrosis-related bronchiectasis, Oxidative balance, Paraoxonase
Kaynak
Astım Allerji İmmünoloji
WoS Q Değeri
Scopus Q Değeri
Cilt
16
Sayı
1
Künye
Pekcan, S., Köse, S. K., Bahar, G., Kurban, S., Güner, Ş. N, (2018). Kistik Fibrozis Dışı Bronşiektazili Çocuk Hastalarda Oksidan ve Antioksidan Denge. Astım Allerji İmmünoloji, 16, 1, 17, 23.
Bağlantı
https://app.trdizin.gov.tr/dokuman-goruntule?ext=pdf&path=CrnWZGRsXTjRjLjWxD978OSUAL2jXitizhVYmCxNvH4axJam75Tq4prNUVfz_hOwbJxPpGvwmhK5Tl5iDzMU_9e0D3-Qwm10kzAQKMjSiuUCwE7GBFmmEn2f5gEWPbzdBKABiCO9iunOuY3vBUmQ6n11WkVpuuqtrxRo_JBU1c5_MNLDJUvpNwyt_BVGiDque0zomhJ6umZM2DBBLHxgJ4cCEPYu6c134I3_HkG0BMI=&contentType=application/pdf
https://hdl.handle.net/20.500.12452/1686
https://hdl.handle.net/20.500.12452/1686
