The Effect of Local Injury to the Endometrium for Implantation and Pregnancy Rates in ICSI - ET Cycles with Implantation Failure: A Randomised Controlled Study
Yükleniyor...
Tarih
2012
Dergi Başlığı
Dergi ISSN
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Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Tekrarlayan implantasyon başarısızlığı olan ICSI-ET (intrasitoplazmik sperm injeksiyonu-embriyo transferi) sikluslarında endometriuma uygulanan lokal hasarın implantasyon, klinik gebelik ve canlı doğum oranlarına olan etkisini araştırmak. Çalışma bir üniversite hastanesinde prospektif olarak tasarlandı ve geçekleştirildi. İnfertilite nedeniyle başvuran ve ICSI-ET yapılması kararlaştırılan, uzun protokol (GnRH analoğu; rFSHHMG) yöntemiyle KOH uygulanacak, tekrarlayan implantasyon başarısızlığı olan toplam 100 hasta seçildi. Aralarından randomize olarak seçilen 50 hastaya KOH siklusundan önce tekrarlanan endometrial biyopsi uygulandı. Hastaların yaş ortalaması, indüksiyon gün süresi, kullanılan toplam gonadotropin dozları, hCG günü E 2 değerleri ve endometrium kalınlıkları, siklus başına toplam MII evresindeki oosit sayıları, transfere uygun kalitedeki total embriyo sayıları, transfer günleri ve transfer edilen embriyo sayıları iki grupta da benzerdi. Benzer sayıda embriyo transferleri ile (çalışma ve kontrol gruplarında sırasıyla 138 ve 141) implantasyon oranları (% 34.67e karşı % 30.8, p 0.05), klinik gebelik oranları (% 60e karşı % 34, p 0.009) ve ET başına canlı doğum oranları (% 44e karşı % 24, p 0.03) çalışma grubunda kontrol grubuna göre daha yüksek bulunmuştur. Bu sonuçlar IVF tedavisi öncesinde endometriuma uygulanan lokal hasarın embriyo implantasyon, klinik gebelik ve canlı doğum oranlarını artırdığını desteklemiştir.
To assess the effect of local injury to the endometrium for implantation, pregnancy and live birth rates in ICSI ET cycles with re- current implantation failure. The study was prospectively designed and performed in a university hospital. A group of 100 women, who failed to conceive during one or more cycles of IVF and embryo transfer (ET), was treated with a long protocol for controlled ovarian hyperstimulation. The IVF treatment and ET were preceded by repeated endometrial biopsies, in a randomly selected 50 of a total of 100 women. Age of the women, days of stimulation, total dose of gonadotropins, E2 concentrations and endometrial thickness on hCG day, total MII stage oocytes, the total number of high quality embryos for transfer, the day of transfer and the number of embryos transferred were similar for both groups. Transfer of a similar number of embryos (138 and 141 in the experi- mental and control patients, respectively) resulted in rates of implantation (34.67 % vs. 30.88 %; p 0,1384) clinical pregnancy (60 % vs. 34 %; p 0.009), and live births per ET (44 % vs. 24 %; p 0.03), which were higher in the experimental group as compared to controls. These results suggest that IVF treatment that is preceded by local injury to the endometrium improved the rates of embryo implantation, clinical pregnancy, and live births in asiste reproductive technique.
To assess the effect of local injury to the endometrium for implantation, pregnancy and live birth rates in ICSI ET cycles with re- current implantation failure. The study was prospectively designed and performed in a university hospital. A group of 100 women, who failed to conceive during one or more cycles of IVF and embryo transfer (ET), was treated with a long protocol for controlled ovarian hyperstimulation. The IVF treatment and ET were preceded by repeated endometrial biopsies, in a randomly selected 50 of a total of 100 women. Age of the women, days of stimulation, total dose of gonadotropins, E2 concentrations and endometrial thickness on hCG day, total MII stage oocytes, the total number of high quality embryos for transfer, the day of transfer and the number of embryos transferred were similar for both groups. Transfer of a similar number of embryos (138 and 141 in the experi- mental and control patients, respectively) resulted in rates of implantation (34.67 % vs. 30.88 %; p 0,1384) clinical pregnancy (60 % vs. 34 %; p 0.009), and live births per ET (44 % vs. 24 %; p 0.03), which were higher in the experimental group as compared to controls. These results suggest that IVF treatment that is preceded by local injury to the endometrium improved the rates of embryo implantation, clinical pregnancy, and live births in asiste reproductive technique.
Açıklama
Anahtar Kelimeler
Endometrium, Local injury, Implantation, Pregnancy, In vitro fertilization, Endometrium, Lokal hasar, İmplantasyon, Doğum, İn-vitro fertilizasyon
Kaynak
European Journal of General Medicine
WoS Q Değeri
Scopus Q Değeri
Cilt
9
Sayı
4
Künye
Görkemli, H., İnal Öztürk, Z. H., İnal, H. A. (2012). The effect of local injury to the endometrium for implantation and pregnancy rates in ICSI - ET cycles with implantation failure: A randomised controlled study. European Journal of General Medicine, 9, 4, 223-229.
