Gastroenteritli Çocukların Dışkılarında Adenovirus ve Rotavirus Sıklığı ve Mevsimsel Dağılımı
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Tarih
2016
Dergi Başlığı
Dergi ISSN
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Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Bu çalışmada, 0-18 yaş grubundaki hastalardan ishal, karın ağrısı, kusma ve ateş gibi şikayetlerle hastanemize başvurup akut gastroenterit ön tanısı alan; bunların içinde laboratuvarımıza virolojik tahlil için gönderilen dışkı örneklerinde rotavirus ve enterik adenovirusların bulunma sıklığını ve bazı demografik özelliklere göre dağılımını araştırmayı hedefledik. Yöntemler: Ocak 2013-Aralık 2015 tarihleri arasında Necmettin Erbakan Üniversitesi, Meram Tıp Fakültesi Hastanesi'ne başvurup akut gastroenterit ön tanısı alan 5156 pediyatrik hastaya ait laboratuvar kayıtları retrospektif olarak incelenmiştir. Dışkı örneklerinde rotavirus ve adenovirus antijenlerini aynı anda immünokromatografik olarak belirleyen VIKIA Rota-Adeno (bioMérieux, Marcy l'Etoile, Fransa) kaset testi, üretici firma önerileri doğrultusunda kullanılmıştır. Bulgular: Toplam 5156 dışkı örneğinin 884 (%17.1)'ünde viral antijenler saptanmıştır. Pozitif saptananların 764 (%14.8) adedi rotavirus, 120 (%2.3) adedi adenovirus olarak belirlenmiştir. Örneğinde antijen saptanan hastalardan 412 (%46.6)'si kız, 472 (%53.4)'si erkektir. Antijen saptanan 884 hastada en sık pozitifliğin %42.1 ile 2-4 yaş (n372) arasındaki hastalarda olduğu görülmüştür. Rotavirusa bağlı gelişen akut gastroenterit olgularının kış ve ilkbahar mevsimlerinde arttığı ve enterik adenoviruslara bağlı gelişen akut gastroenterit olgularının ise tüm yıl boyunca saptandığı gözlenmiştir. Sonuçlar: Yenidoğan ve küçük çocuklarda görülen ciddi gastroenteritlerin en yaygın sebebi olan rotavirusların, özellikle ilk 4 yaştaki ishal olgularında akla getirilmesi gerekmektedir. Etkenin tanısının hızlı konması, hastanın kliniğinin öngörülmesi ve tedavi yaklaşımı bakımından önemlidir. Enterik adenovirusların, sütçocukluğu ve çocukluk döneminde önemli bir gastroenterit nedeni olması; adenovirus antijenlerinin de araştırılmasını gerekli kılmaktadır. Yapılan bölgesel çalışmalar, epidemiyolojik bilgilere katkı sağlaması açısından önemlidir.
Objective: In our study, we aimed to investigate the prevalence of rotavirus and enteric adenovirus in stool samples sent to our laboratory for antigen detection of children between 0-18 years of age admitted to hospital with diarrhea, abdominal pain, vomiting and fever and diagnosed as gastroenteritis. We also analyzed their frequencies according to demographic parameters. Methods: Results of 5156 pediatric patients admitted to Necmettin Erbakan University Meram Faculty of Medicine Hospital and diagnosed as gastroenteritis between January 2013-December 2015 were investigated retrospectively. VIKIA® RotaAdeno (bioMérieux, Marcy l'Etoile, France), a chromatographic immunoassay detecting both viruses simultaneously was used according to the manufacturer's recommendations in stool samples. Results: Viral antigens were detected in 884 (17.1%) of the total 5156 samples. 764 (14.8%) of the positive results were detected as rotavirus and 120 (2.3%) were detected as adenovirus. Of the patients with positive results, 412 (46.6%) were female and 472 (53.4%) were male. When results are considered according to age, 2-4 age group was found to have the most common positivity (n372) as 42.1%. Seasonal distribution of acute gastroenteritis cases was analyzed and the number of cases due to rotavirus was found to be increased in winter and spring and enteric adenoviruses were detected all year round. Conclusions: Rotavirus is the most common reason of gastroenteritis in the newborn and children, which must be considered for patients with diarrhea especially in the first four years of life. Rapid diagnosis is important for prediction of clinical implications and treatment. As enteric adenovirus is an important reason of gastroenteritis in infancy and childhood, it is necessary to investigate adenovirus antigens as well. Conducting regional studies are important for contributing to epidemiological data.
Objective: In our study, we aimed to investigate the prevalence of rotavirus and enteric adenovirus in stool samples sent to our laboratory for antigen detection of children between 0-18 years of age admitted to hospital with diarrhea, abdominal pain, vomiting and fever and diagnosed as gastroenteritis. We also analyzed their frequencies according to demographic parameters. Methods: Results of 5156 pediatric patients admitted to Necmettin Erbakan University Meram Faculty of Medicine Hospital and diagnosed as gastroenteritis between January 2013-December 2015 were investigated retrospectively. VIKIA® RotaAdeno (bioMérieux, Marcy l'Etoile, France), a chromatographic immunoassay detecting both viruses simultaneously was used according to the manufacturer's recommendations in stool samples. Results: Viral antigens were detected in 884 (17.1%) of the total 5156 samples. 764 (14.8%) of the positive results were detected as rotavirus and 120 (2.3%) were detected as adenovirus. Of the patients with positive results, 412 (46.6%) were female and 472 (53.4%) were male. When results are considered according to age, 2-4 age group was found to have the most common positivity (n372) as 42.1%. Seasonal distribution of acute gastroenteritis cases was analyzed and the number of cases due to rotavirus was found to be increased in winter and spring and enteric adenoviruses were detected all year round. Conclusions: Rotavirus is the most common reason of gastroenteritis in the newborn and children, which must be considered for patients with diarrhea especially in the first four years of life. Rapid diagnosis is important for prediction of clinical implications and treatment. As enteric adenovirus is an important reason of gastroenteritis in infancy and childhood, it is necessary to investigate adenovirus antigens as well. Conducting regional studies are important for contributing to epidemiological data.
Açıklama
Anahtar Kelimeler
Gastroenterit, Rotavirus, Adenovirus, Gastroenteritis
Kaynak
Klimik Dergisi
WoS Q Değeri
Scopus Q Değeri
Q4
Cilt
29
Sayı
3
Künye
Feyzioğlu, B., Özdemir, M., Saran Gülcen, B., Tüzüner, U. (2016). Gastroenteritli çocukların dışkılarında adenovirus ve rotavirus sıklığı ve mevsimsel dağılımı. Klimik Dergisi, 29, 3, 121-124.
