Is there any potential or additive effect of anemia on hepatorenal syndrome?

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dc.authoridMuharrem Keskin: 0000-0002-5696-4752
dc.authoridHüseyin Ataseven: 0000-0001-8515-8760
dc.authoridGökhan Güngör: 0000-0002-8199-6617
dc.contributor.authorKeskin, Muharrem
dc.contributor.authorBıyık, Murat
dc.contributor.authorAtaseven, Hüseyin
dc.contributor.authorDemir, Ali
dc.contributor.authorGüngör, Gökhan
dc.contributor.authorAkyıldız, Murat
dc.contributor.authorSolak, Yalçın
dc.contributor.authorGaipov, Abduzhappar
dc.contributor.authorÇifçi, Sami
dc.contributor.authorPolat, Hakkı
dc.date.accessioned2020-01-18T21:02:52Z
dc.date.available2020-01-18T21:02:52Z
dc.date.issued2016
dc.departmentNEÜ, Meram Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Anabilim Dalıen_US
dc.description.abstractBackground/Aims: Hepatorenal syndrome (HRS) is a severe complication of advanced cirrhosis and is characterized by renal dysfunction and poor survival rates. Although anemia is a non-rare condition in advanced liver cirrhosis, there is no publication regarding the potential or additive effects of anemia on HRS and renal dysfunction in patients with cirrhosis. We investigated whether severe anemia is a precipitant factor for HRS.Materials and Methods: In this prospective study, consecutive patients with cirrhosis with and without renal dysfunction were enrolled. A total of 29 patients with cirrhosis with HRS meeting the HRS diagnostic criteria (9 patients with type 1 HRS and 20 with type 2 HRS) and 37 patients with cirrhosis without HRS were included. The demographic features, laboratory data (particularly anemic parameters), and clinical scores of patients with and without HRS were evaluated.Results: Grades of ascites, Child-Turcotte-Pugh (CTP) scores, and Model of End Stage Liver Disease (MELD) scores were significantly higher in contrast to hemoglobin levels; hematocrit concentrations were significantly lower in patients with type 1 and 2 HRS than in those with non-HRS stable cirrhosis. There was a negative correlation between the hemoglobin-hematocrit and serum creatinine levels. In the logistic regression analysis, the hemoglobin levels and CTP and MELD scores were statistically significant for an onset of HRS.Conclusion: Anemia may contribute to HRS and deteriorated renal function in patients with HRS because anemic hypoxia can lead to microcirculatory renal ischemia in the kidneys and anemia can also activate sympathetic activity and hyperdynamic circulation in the pathogenesis of HRS.en_US
dc.identifier.citationKeskin, M., Bıyık, M., Ataseven, H., Demir, A., Güngör, G., Akyıldız, M., Solak, Y., Gaipov, A., Çifçi, S., Polat, H. (2016). Is there any potential or additive effect of anemia on hepatorenal syndrome?. Turkish Journal of Gastroenterology, 27, 3, 273-278.
dc.identifier.doi10.5152/tjg.2016.16029en_US
dc.identifier.endpage278en_US
dc.identifier.issn1300-4948en_US
dc.identifier.issn2148-5607en_US
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage273en_US
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TWpBM05UZzFOUT09/is-there-any-potential-or-additive-effect-of-anemia-on-hepatorenal-syndrome-
dc.identifier.urihttps://hdl.handle.net/20.500.12452/1331
dc.identifier.volume27en_US
dc.identifier.wosWOS:000376888000013en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Gastroenterologyen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US]
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectLiver cirrhosisen_US
dc.subjectAnemiaen_US
dc.subjectRenal hypoxiaen_US
dc.subjectRenal dysfunctionen_US
dc.subjectHepatorenal syndromeen_US
dc.titleIs there any potential or additive effect of anemia on hepatorenal syndrome?en_US
dc.typeArticleen_US

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