Effects of resveratrol and cigarette smoking on bone healing: Histomorphometric evaluation
Yükleniyor...
Tarih
2016
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Background/aim: The aim of the present study is to investigate the effects of cigarette smoke (CS) and simultaneous application of resveratrol on bone healing histomorphometrically and to evaluate the effects of resveratrol on negative effects of CS. Materials and methods: For 4 weeks, Sprague Dawley rats were exposed to cigarette smoke at the equivalent of 6 cigarettes per day. After this period, monocortical defects were created in femurs by a trephine bur on day 28. Starting from the day of defect creation to the 28th postoperative day, rats were given 20 mg/kg body weight resveratrol. Histomorphometric examination of the number of osteoblasts and osteoclasts, as well as new bone area, was conducted. Results: Investigations were carried out on 33 rats. Differences between osteoblast numbers in the control and CS groups were significant, and CS caused a reduction in the number of osteoblasts. Areas of new bone formation in the resveratrol and control groups were higher than in the smoking and smokingresveratrol groups. Conclusion: Smoking appeared to have adverse effects upon bone healing and resveratrol administration helped to reduce these effects.
Açıklama
WOS:000378646700039
PubMed ID:27513426
PubMed ID:27513426
Anahtar Kelimeler
Cigarette smoking, Resveratrol, New bone area, Osteoblast, Osteoclast
Kaynak
Turkish Journal of Medical Sciences
WoS Q Değeri
Q3
Scopus Q Değeri
Q3
Cilt
46
Sayı
4
Künye
Kolkesen Şahin, O., Çına Aksoy, M., Avunduk, M. C. (2016). Effects of resveratrol and cigarette smoking on bone healing: Histomorphometric evaluation. Turkish Journal of Medical Sciences, 46, 4, 1203-1208.
