Effects of resveratrol and cigarette smoking on bone healing: Histomorphometric evaluation

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dc.authoridMustafa Cihat Avunduk: 0000-0002-8709-8949en_US
dc.contributor.authorKolkesen Şahin, Özge
dc.contributor.authorAksoy, Müge Çina
dc.contributor.authorAvunduk, Mustafa Cihat
dc.date.accessioned2020-01-18T21:02:51Z
dc.date.available2020-01-18T21:02:51Z
dc.date.issued2016
dc.departmentNEÜ, Meram Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Tıbbi Patoloji Anabilim Dalıen_US
dc.descriptionWOS:000378646700039en_US
dc.descriptionPubMed ID:27513426en_US
dc.description.abstractBackground/aim: The aim of the present study is to investigate the effects of cigarette smoke (CS) and simultaneous application of resveratrol on bone healing histomorphometrically and to evaluate the effects of resveratrol on negative effects of CS. Materials and methods: For 4 weeks, Sprague Dawley rats were exposed to cigarette smoke at the equivalent of 6 cigarettes per day. After this period, monocortical defects were created in femurs by a trephine bur on day 28. Starting from the day of defect creation to the 28th postoperative day, rats were given 20 mg/kg body weight resveratrol. Histomorphometric examination of the number of osteoblasts and osteoclasts, as well as new bone area, was conducted. Results: Investigations were carried out on 33 rats. Differences between osteoblast numbers in the control and CS groups were significant, and CS caused a reduction in the number of osteoblasts. Areas of new bone formation in the resveratrol and control groups were higher than in the smoking and smokingresveratrol groups. Conclusion: Smoking appeared to have adverse effects upon bone healing and resveratrol administration helped to reduce these effects.en_US
dc.identifier.citationKolkesen Şahin, O., Çına Aksoy, M., Avunduk, M. C. (2016). Effects of resveratrol and cigarette smoking on bone healing: Histomorphometric evaluation. Turkish Journal of Medical Sciences, 46, 4, 1203-1208.en_US
dc.identifier.doi10.3906/sag-1501-109en_US
dc.identifier.endpage1208en_US
dc.identifier.issn1300-0144en_US
dc.identifier.issn1303-6165en_US
dc.identifier.issue4en_US
dc.identifier.pmid27513426en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1203en_US
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TWpRNU5qUTJOZz09/effects-of-resveratrol-and-cigarette-smoking-on-bone-healing-histomorphometric-evaluation
dc.identifier.urihttps://hdl.handle.net/20.500.12452/1321
dc.identifier.volume46en_US
dc.identifier.wosWOS:000378646700039en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US]
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCigarette smokingen_US
dc.subjectResveratrolen_US
dc.subjectNew bone areaen_US
dc.subjectOsteoblasten_US
dc.subjectOsteoclasten_US
dc.titleEffects of resveratrol and cigarette smoking on bone healing: Histomorphometric evaluationen_US
dc.typeArticleen_US

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