Tip1 ve tip2 diyabetus mellitus hastalarında; Ekzokrinpankreas yetmezliği sıklığının araştırılması ve çeşitli klinikve laboratuvar parametreleriyle ilişkisinin incelenmesi
Yükleniyor...
Tarih
2023
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Necmettin Erbakan Üniversitesi Meram Tıp Fakültesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Introduction: Pancreatic enzyme deficiency (PEI) is a common clinical condition in
patients with Diabetes Mellitus. The aim of our thesis study is to determine the frequency of
pancreatic enzyme insufficiency in patients with Type 1 or Type 2 DM in Necmettin Erbakan
University Meram Faculty of Medicine, Department of Internal Medicine, Endocrinology and
Metabolism Diseases Department and service, and to retrospectively examine the clinical and
laboratory tests of these patients and evaluate the difference to evaluate relationships.
Methods: Fecal samples were obtained from 165 patients with Type 1 or Type 2 DM
who were followed up in Necmettin Erbakan University Meram Faculty of Medicine,
Department of Internal Diseases, Endocrinology and Metabolic Diseases Outpatient Clinic
and service. The fecal samples taken were kept at -80 degrees until FE-1 biochemistry study
kits were obtained. Fecal elastase 1 (FE1) level was measured using enzyme-linked-immune
assay (ELISA) kits for the presence of PEI in fecal samples. Fecal elastase levels of 200 μg/g
were classified as normal exocrine function, 100-200 μg/g as mild to moderate exocrine
pancreatic insufficiency (PEI), and <100 μg/g as severe PEY. The patients were divided into
3 main groups as type 2 DM using insulin, type 2 DM only using OAD, and type 1 DM. In
our study, the clinical and laboratory tests between these 3 groups were retrospectively
analyzed and the relationship between them was evaluated. A questionnaire was administered
to the patients regarding the diagnosis and symptoms of PEY. According to the results of the
questionnaire, they were evaluated as patients with mild, moderate and severe PEI symptoms
and who were not considered to have PEI.
In conclusion: Of 165 patients with DM, 44 had Type 1 DM and 121 had Type 2 DM. Of
the patients diagnosed with Type 2 DM, 58 were on insulin and 63 were on oral antidiabetics
(OAD). Of 165 patients, 80 (48.50%) had PEY and 85 (51.51%) did not have PEI. The rate of
PEI was 59.1% in type 1 DM patients and 44.6% in 121 type 2 DM patients. Patients in the group
with severe PEI had a longer diagnostic period and were insulin users. The questionnaire revealed
that symptom severity increased as the severity of PEI increased.
Results: PEI is a common condition in diabetic patients. Patients diagnosed with
diabetes should be evaluated in terms of PEI, PEI symptoms should be questioned, and
further examination should be performed when necessary.
Açıklama
Anahtar Kelimeler
Ekzokrin pankreatik yetmezlik(PEY), Diyabetus mellitus, Fekal elastaz, Exocrine pancreatic insufficiency, Diabetes mellitus, Fecal elastase
Kaynak
WoS Q Değeri
Scopus Q Değeri
Cilt
Sayı
Künye
Karabulut, B. (2023). Tip1 ve tip2 diyabetus mellitus hastalarında; Ekzokrinpankreas yetmezliği sıklığının araştırılması ve çeşitli klinikve laboratuvar parametreleriyle ilişkisinin incelenmesi. (Yayınlanmamış tıpta uzmanlık tezi) Necmettin Erbakan Üniversitesi, Meram Tıp Fakültesi Dahilİ Tıp Bilimleri Bölümü İç Hastalıkları Anabilim Dalı, Konya.
