Tip1 ve tip2 diyabetus mellitus hastalarında; Ekzokrinpankreas yetmezliği sıklığının araştırılması ve çeşitli klinikve laboratuvar parametreleriyle ilişkisinin incelenmesi

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dc.contributor.advisorAsıl, Mehmet
dc.contributor.authorKarabulut, Burcu
dc.date.accessioned2023-10-26T12:12:51Z
dc.date.available2023-10-26T12:12:51Z
dc.date.issued2023en_US
dc.date.submitted2023
dc.departmentNEÜ, Meram Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Anabilim Dalıen_US
dc.description.abstractIntroduction: Pancreatic enzyme deficiency (PEI) is a common clinical condition in patients with Diabetes Mellitus. The aim of our thesis study is to determine the frequency of pancreatic enzyme insufficiency in patients with Type 1 or Type 2 DM in Necmettin Erbakan University Meram Faculty of Medicine, Department of Internal Medicine, Endocrinology and Metabolism Diseases Department and service, and to retrospectively examine the clinical and laboratory tests of these patients and evaluate the difference to evaluate relationships. Methods: Fecal samples were obtained from 165 patients with Type 1 or Type 2 DM who were followed up in Necmettin Erbakan University Meram Faculty of Medicine, Department of Internal Diseases, Endocrinology and Metabolic Diseases Outpatient Clinic and service. The fecal samples taken were kept at -80 degrees until FE-1 biochemistry study kits were obtained. Fecal elastase 1 (FE1) level was measured using enzyme-linked-immune assay (ELISA) kits for the presence of PEI in fecal samples. Fecal elastase levels of 200 μg/g were classified as normal exocrine function, 100-200 μg/g as mild to moderate exocrine pancreatic insufficiency (PEI), and <100 μg/g as severe PEY. The patients were divided into 3 main groups as type 2 DM using insulin, type 2 DM only using OAD, and type 1 DM. In our study, the clinical and laboratory tests between these 3 groups were retrospectively analyzed and the relationship between them was evaluated. A questionnaire was administered to the patients regarding the diagnosis and symptoms of PEY. According to the results of the questionnaire, they were evaluated as patients with mild, moderate and severe PEI symptoms and who were not considered to have PEI. In conclusion: Of 165 patients with DM, 44 had Type 1 DM and 121 had Type 2 DM. Of the patients diagnosed with Type 2 DM, 58 were on insulin and 63 were on oral antidiabetics (OAD). Of 165 patients, 80 (48.50%) had PEY and 85 (51.51%) did not have PEI. The rate of PEI was 59.1% in type 1 DM patients and 44.6% in 121 type 2 DM patients. Patients in the group with severe PEI had a longer diagnostic period and were insulin users. The questionnaire revealed that symptom severity increased as the severity of PEI increased. Results: PEI is a common condition in diabetic patients. Patients diagnosed with diabetes should be evaluated in terms of PEI, PEI symptoms should be questioned, and further examination should be performed when necessary.en_US
dc.identifier.citationKarabulut, B. (2023). Tip1 ve tip2 diyabetus mellitus hastalarında; Ekzokrinpankreas yetmezliği sıklığının araştırılması ve çeşitli klinikve laboratuvar parametreleriyle ilişkisinin incelenmesi. (Yayınlanmamış tıpta uzmanlık tezi) Necmettin Erbakan Üniversitesi, Meram Tıp Fakültesi Dahilİ Tıp Bilimleri Bölümü İç Hastalıkları Anabilim Dalı, Konya.en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12452/10185
dc.language.isotren_US
dc.publisherNecmettin Erbakan Üniversitesi Meram Tıp Fakültesien_US
dc.relation.publicationcategoryTezen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEkzokrin pankreatik yetmezlik(PEY)en_US
dc.subjectDiyabetus mellitusen_US
dc.subjectFekal elastazen_US
dc.subjectExocrine pancreatic insufficiencyen_US
dc.subjectDiabetes mellitusen_US
dc.subjectFecal elastaseen_US
dc.titleTip1 ve tip2 diyabetus mellitus hastalarında; Ekzokrinpankreas yetmezliği sıklığının araştırılması ve çeşitli klinikve laboratuvar parametreleriyle ilişkisinin incelenmesien_US
dc.title.alternativeType1 and type2 diabetus mellitus patients; Exocrineinvestigation of the frequency of pancreas failure and various clinic and investigation of the relationship with laboratory parametersen_US
dc.typeSpecialist Thesisen_US

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