What is the place of empirical proton pump inhibitor testing in the diagnosis of gastroesophageal reflux disease? (Description, duration, and dosage)

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dc.authorid0000-0002-5696-4752en_US
dc.contributor.authorVardar, Rukiye
dc.contributor.authorKeskin, Muharrem
dc.date.accessioned2020-01-18T21:02:53Z
dc.date.available2020-01-18T21:02:53Z
dc.date.issued2017
dc.departmentNEÜ, Meram Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Anabilim Dalıen_US
dc.descriptionWOS:000417204500004en_US
dc.descriptionPubMed ID:29199160en_US
dc.description.abstractEmpirical acid suppression tests that are performed with proton pump inhibitors (PPI) are used to detect both the presence of acid-related gastrointestinal symptoms and gastroesophageal reflux disease (GERD). In comparison to other diagnostic methods, it is non-invasive, easily applicable, and cost-effective in the diagnosis of GERD. In addition to typical reflux symptoms, it can also be used for diagnostic purposes in patients with non-cardiac chest pain (NCCP). If the symptom response is 50% and above when obtained using the PPI test in patients with NCCP, it can be considered as positive and the treatment should be continued sensitivity of the PPI test in patients with typical symptoms of GERD is 27%-89%, while its specificity is 35%-83%. Although there are differences related to the duration and dosage of the PPI test, a significant difference has not been found according to the type of PPI. When PPI test sensitivity and specificity were calculated by cumulatively evaluating the data regarding the PPI test in the literature, a sensitivity of 82.3% and specificity of 51.5% was obtained. It has been found that high doses of PPI were mostly used in studies, and the duration of the median test was 14 days. As a result, the sensitivity of PPI trial test is good, but the specificity is low in the diagnosis of GERD in patients with typical reflux symptomsen_US
dc.identifier.citationVardar, R., Keskin, M. (2017). What is the place of empirical proton pump inhibitor testing in the diagnosis of gastroesophageal reflux disease? (Description, duration, and dosage). The Turkish Journal of Gastroenterology, 28, 1, 12-15.en_US
dc.identifier.doi10.5152/tjg.2017.05en_US
dc.identifier.endpage15en_US
dc.identifier.issn1300-4948en_US
dc.identifier.issn2148-5607en_US
dc.identifier.issue1en_US
dc.identifier.pmid29199160en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage12en_US
dc.identifier.urihttp://app.trdizin.gov.tr/publication/paper/detail/TWpZM05UUTRPQT09
dc.identifier.urihttps://hdl.handle.net/20.500.12452/1345
dc.identifier.volume28en_US
dc.identifier.wosWOS:000417204500004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Gastroenterologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US]
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCerrahien_US
dc.subjectEmpirical Ppı Testen_US
dc.subjectGerden_US
dc.subjectPpı Trial Testen_US
dc.titleWhat is the place of empirical proton pump inhibitor testing in the diagnosis of gastroesophageal reflux disease? (Description, duration, and dosage)en_US
dc.typeArticleen_US

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