Serum Heat Shock Protein 70, S100A12 and Matrix Gla Protein in Childhood Obesity and Metabolic Syndrome
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Dosyalar
Tarih
2016
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Metabolik Sendromun primer nedeni erişkin ve çocuk popülasyonunda insülin rezistansı ile sonuçlanan düşük dereceli inflamasyon ile ilgili obezitedir. Heat şok protein 70,S100A12 ve matriks Gla protein kronik inflamatuar hastalık ile ilgilidir. Çocuk çağı obezitesi ve metabolik sendromun da bu markırları değerlendirmeyi amaçladık. Gereç ve Yöntem: Bu çalışma 10-15 yaş aralığında 45 obez çocuk ve 47 metabolik sendrom'lu çocukta yapıldı. Heat şok protein 70, S100A12 ve matriks Gla protein ELISA metodu kullanılarak ölçüldü.Bulgular: Obez çocuklarda serum matriks Gla protein ve S100A12 seviyeleri metabolik sendrom'lu gruptan anlamlı olarak yüksekti (p0.05). İlaveten, metabolik sendrom ve obez bireyler arasında serum hsCRP (p0.288) ve heat şok protein 70 (p0.960) fark yoktu. Her iki grupta S100A12, matriks Gla protein ve heat şok protein 70 seviyeleri arasında anlamlı pozitif korelasyon vardı. Sonuç: Bulgularımız S100A12, matriks Gla protein ve heat şok protein 70 biyomarkırları metabolik sendrom ve obezite ile anlamlı olarak ilgili olduğunu gösterdi. Obezite metabolik sendrom gelişiminde önemli bir risk faktörüdür. Obezitede bu proteinlerin artışı, metabolik sendrom ve diabet gibi metabolik bozuklukların gelişiminin önlenmesinde ilgi çekici olabilir.
Objectives: The primary cause of the metabolic syndrome appears to be obesity that is associated with a low-grade inflammatory state resulting from insulin resistance in both adult and pediatric populations. Heat shock protein 70, S100A12 and matrix Gla protein are involved in chronic inflammatory diseases. We aimed to evaluate the association between these markers and childhood obesity and metabolic syndrome. Materials and Methods: This study was performed with 45 obese children aged 10-15 years and 47 children with metabolic syndrome aged 10-15 years. Serum heat shock protein 70, S100A12 and matrix Gla protein levels were measured by using ELISA method. Results: Serum matrix Gla protein and S100A12 levels in obese subjects were significantly higher than metabolic syndrome groups (p>0.05). However no significant differences were observed in serum high sensitivity Creactive protein (p0.288) and heat shock protein 70 (p0.960) levels between metabolic syndrome and obese subjects. There was a significant positive correlation between serum S100A12, matrix Gla protein and heat shock protein 70 levels in both groups. Conclusions: Our findings showed a significant association between heat shock protein 70, S100A12, matrix Gla protein, and obesity and metabolic syndrome. Obesity may be involved in increased risk of developing metabolic syndrome. It might be useful to focus on the roles of these proteins in obesity in accordance with the prevention of the development of metabolic syndrome and other metabolic disorders like diabetes.
Objectives: The primary cause of the metabolic syndrome appears to be obesity that is associated with a low-grade inflammatory state resulting from insulin resistance in both adult and pediatric populations. Heat shock protein 70, S100A12 and matrix Gla protein are involved in chronic inflammatory diseases. We aimed to evaluate the association between these markers and childhood obesity and metabolic syndrome. Materials and Methods: This study was performed with 45 obese children aged 10-15 years and 47 children with metabolic syndrome aged 10-15 years. Serum heat shock protein 70, S100A12 and matrix Gla protein levels were measured by using ELISA method. Results: Serum matrix Gla protein and S100A12 levels in obese subjects were significantly higher than metabolic syndrome groups (p>0.05). However no significant differences were observed in serum high sensitivity Creactive protein (p0.288) and heat shock protein 70 (p0.960) levels between metabolic syndrome and obese subjects. There was a significant positive correlation between serum S100A12, matrix Gla protein and heat shock protein 70 levels in both groups. Conclusions: Our findings showed a significant association between heat shock protein 70, S100A12, matrix Gla protein, and obesity and metabolic syndrome. Obesity may be involved in increased risk of developing metabolic syndrome. It might be useful to focus on the roles of these proteins in obesity in accordance with the prevention of the development of metabolic syndrome and other metabolic disorders like diabetes.
Açıklama
Anahtar Kelimeler
Cerrahi, Obesity, Metabolic Syndrome, Heat Shock Protein 70, S100a12 And Matrix Gla Protein, Obezite, Metabolik Sendrom, Heat Şok Protein 70, S100a12, Matriks Gla Protein
Kaynak
Van Tıp Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
23
Sayı
4
Künye
Can, Ü., Büyükinan, M., Güzelant, A., Karaibrahimoğlu, A. (2016). Serum Heat Shock Protein 70, S100A12 and Matrix Gla Protein in Childhood Obesity and Metabolic Syndrome. Van Tıp Dergisi, 23, 4, 307-312.
