Two Different Presentation of C3 Glomerulonephritis Treated with Eculizumab: Two Cases and Brief Overview
Yükleniyor...
Tarih
2023
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Aves
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
C3 glomerulopathy is a newly defined glomerular disease dominated by C3 complement storage and uncertain C1, C4, and
immunoglobin accumulations. Hereditary mutations associated with Complement Factor H (CFH) causing hyperactivation
of the alternative complement pathway were identified. Most mutations associated with C3 glomerulopathy are associated
with the N-terminal end. Whether mutations are pathogenic or not will direct diagnosis and treatment. We present 2 cases,
one 61-year-old and one 24-year-old attending our clinic at different times with hematuria, proteinuria, edema, and kidney
failure. Both patients had C3 glomerulopathy diagnosed based on the results of kidney biopsy and were treated with eculizumab. Both cases had CFH-associated mutations.
Açıklama
Makale
WOS:000925209300013
WOS:000925209300013
Anahtar Kelimeler
Clinical Nephrology, C3 Glomerulopathy, CFH, Eculizumab, Mutation, Pathology
Kaynak
Turkish Journal of Nephrology
WoS Q Değeri
Scopus Q Değeri
Cilt
32
Sayı
1
Künye
Öztürk, Y., Özer, H., Baloğlu, İ., Türkmen, K. (2023). Two different presentation of C3 glomerulonephritis treated with eculizumab: Two cases and brief overview. Turkish Journal of Nephrology, 32, 1, 86-89.
