Two Different Presentation of C3 Glomerulonephritis Treated with Eculizumab: Two Cases and Brief Overview

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dc.authoridYasin Öztürk: 0000-0003-2634-2677en_US
dc.authoridHakan Özer: 0000-0001-9174-0351en_US
dc.authoridİsmail Baloğlu: 0000-0002-8751-5490en_US
dc.authoridKültigin Türkmen: 0000-0002-1667-7716en_US
dc.contributor.authorÖztürk, Yasin
dc.contributor.authorÖzer, Hakan
dc.contributor.authorBaloğlu, İsmail
dc.contributor.authorTürkmen, Kültigin
dc.date.accessioned2023-05-18T11:39:25Z
dc.date.available2023-05-18T11:39:25Z
dc.date.issued2023en_US
dc.departmentNEÜ, Meram Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Anabilim Dalıen_US
dc.descriptionMakaleen_US
dc.descriptionWOS:000925209300013en_US
dc.description.abstractC3 glomerulopathy is a newly defined glomerular disease dominated by C3 complement storage and uncertain C1, C4, and immunoglobin accumulations. Hereditary mutations associated with Complement Factor H (CFH) causing hyperactivation of the alternative complement pathway were identified. Most mutations associated with C3 glomerulopathy are associated with the N-terminal end. Whether mutations are pathogenic or not will direct diagnosis and treatment. We present 2 cases, one 61-year-old and one 24-year-old attending our clinic at different times with hematuria, proteinuria, edema, and kidney failure. Both patients had C3 glomerulopathy diagnosed based on the results of kidney biopsy and were treated with eculizumab. Both cases had CFH-associated mutations.en_US
dc.identifier.citationÖztürk, Y., Özer, H., Baloğlu, İ., Türkmen, K. (2023). Two different presentation of C3 glomerulonephritis treated with eculizumab: Two cases and brief overview. Turkish Journal of Nephrology, 32, 1, 86-89.en_US
dc.identifier.doi10.5152/turkjnephrol.2023.21141125en_US
dc.identifier.endpage86en_US
dc.identifier.issue1en_US
dc.identifier.startpage86en_US
dc.identifier.urihttp://dx.doi.org/10.5152/turkjnephrol.2023.21141125
dc.identifier.urihttps://hdl.handle.net/20.500.12452/9647
dc.identifier.volume32en_US
dc.identifier.wosWOS:000925209300013en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherAvesen_US
dc.relation.ispartofTurkish Journal of Nephrologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectClinical Nephrologyen_US
dc.subjectC3 Glomerulopathyen_US
dc.subjectCFHen_US
dc.subjectEculizumaben_US
dc.subjectMutationen_US
dc.subjectPathologyen_US
dc.titleTwo Different Presentation of C3 Glomerulonephritis Treated with Eculizumab: Two Cases and Brief Overviewen_US
dc.typeArticleen_US

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