Efficacy of Low Density Linear Shockwave Treatment in Severe Arteriogenic Erectile Dysfunction Patients
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Tarih
2017
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Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Bu çalışmanın amacı, şiddetli arteriyojenik erektil disfonksiyona (ED) sahip hastalarda, fosfodiesteraz tip 5 (PDESİ) inhibitörünün (Tadalafil 5 mg) günlük kullanımı ile kombine edilen düşük dansiteli lineer şok dalga tedavisini (LI-ESWT), sadece PDESİ'nin günlük kullanımı ile kıyaslayarak LI-ESWT'nin etkinliğini değerlendirmektir.Gereç ve Yöntem: Toplam 23 hasta çalışmaya dahil edildi. Bu hastalar LI-ESWT tadalafil 5 mg tedavisi (n10) uygulanan, sadece tadalafil 5 mg tedavisi uygulanan (n13) hastalar şeklinde iki gruba ayrıldı. LI-ESWT, 4 hafta boyunca haftada bir kez uygulandı. Her iki gruptaki hastalara da günde bir defa tadalafil 5 mg tedavisi oral olarak başlandı ve tedaviye her iki grupta 3 ay devam edildi. Tedavi öncesi ve sonrası 1. ay ve 3. ayda hastalar Uluslararası Erektil Fonksiyon İndeks Formu-Erektil Fonksiyon Alanı Skoru (IIEF-EF) ve Ereksiyon Sertlik Derecesi Skoru (ESDS) seviyeleri ve Seksüel İlişki Profili (SEP) 2 ve 3 ile değerlendirildi. Bulgular: Tedavi öncesi ve tedavi sonrası 1. ve 3. ayda ölçülen IIEF-EF skorları arasında istatiksel anlamlı fark saptanmadı (p0,091; p0,198). Üçüncü ay sonunda LI-ESWT tadalafil 5 mg grubunda IIEF-EF skoru 4 puan, Tadalafil 5 mg grubunda 3,2 puan artış gösterdi. İki grup arasında 1. ve 3. ayda ölçülen ESDS, SEP2 ve SEP3 pozitif hasta oranları arasında istatistiksel olarak anlamlı fark saptanmadı.Sonuç: LI-ESWT, ED tedavisinde kolay uygulanabilir, belirgin yan etkisi olamayan ve sonuçlar üzerinde pozitif etkisi olan bir uygulamadır. Fakat ağır arteriyojenik ED mevcut hastalarda etkin bir tedavi yöntemi değildir.
Objective: The aim of this study was to evaluate the efficacy of low-intensity linear shockwave treatment (LI-ESWT) in patients with severe arteriogenic erectile dysfunction (ED) by comparing LI-ESWT combined with daily use of phosphodiesterase type 5 inhibitors (PDE5i) with the daily use of PDE5i alone.Materials and Methods: A total of 23 patients were included in the study. The patients were separated into two groups: LI-ESWT tadalafil 5 mg (n10) group and tadalafil 5 mg only group (n13). LI-ESWT was applied once a week for four weeks. Oral tadalafil 5 mg once a day was started and continued for three months in both groups. The patients were evaluated with the International Erectile Function Index Questionnaire Erectile Function Domain (IIEF-EF), Erection Hardness Score (EHS) and Sexual Encounter Profile (SEP) 2 and 3 before treatment and the 1 and 3 months after treatment. Results: No statistically significant difference was detected among IIEF-EF scores measured before and 1 and 3 months after treatment (p0.091, p0.198). At the end of the third month, IIEF score increased 4 points in LI-ESWT tadalafil 5 mg group and 3.2 points in tadalafil 5 mg only group. No statistically significant difference was detected in EHS, and the rate of positive responses to SEP2 and SEP3 questions at the 1st and 3rd months between the groups.Conclusion: LI-ESWT is easily applicable without any significant side effects and it has positive effects on the outcomes, however, it is not an effective treatment method in patients with severe arteriogenic ED.
Objective: The aim of this study was to evaluate the efficacy of low-intensity linear shockwave treatment (LI-ESWT) in patients with severe arteriogenic erectile dysfunction (ED) by comparing LI-ESWT combined with daily use of phosphodiesterase type 5 inhibitors (PDE5i) with the daily use of PDE5i alone.Materials and Methods: A total of 23 patients were included in the study. The patients were separated into two groups: LI-ESWT tadalafil 5 mg (n10) group and tadalafil 5 mg only group (n13). LI-ESWT was applied once a week for four weeks. Oral tadalafil 5 mg once a day was started and continued for three months in both groups. The patients were evaluated with the International Erectile Function Index Questionnaire Erectile Function Domain (IIEF-EF), Erection Hardness Score (EHS) and Sexual Encounter Profile (SEP) 2 and 3 before treatment and the 1 and 3 months after treatment. Results: No statistically significant difference was detected among IIEF-EF scores measured before and 1 and 3 months after treatment (p0.091, p0.198). At the end of the third month, IIEF score increased 4 points in LI-ESWT tadalafil 5 mg group and 3.2 points in tadalafil 5 mg only group. No statistically significant difference was detected in EHS, and the rate of positive responses to SEP2 and SEP3 questions at the 1st and 3rd months between the groups.Conclusion: LI-ESWT is easily applicable without any significant side effects and it has positive effects on the outcomes, however, it is not an effective treatment method in patients with severe arteriogenic ED.
Açıklama
WOS:000419241900006
Anahtar Kelimeler
Low-İntensity linear shockwave treatment, Phospodiesterase type 5 inhibitors, Erectile dysfunction, Düşük dansiteli linear şok dalga tedavisi, Fosfodiesteraz tip 5 inhibitörleri, Erektil disfonksiyon
Kaynak
Journal of Urological Surgery
WoS Q Değeri
Scopus Q Değeri
Cilt
4
Sayı
4
Künye
Sönmez, M. G., Kara, C. (2017). Efficacy of low density linear shockwave treatment in Severe arteriogenic erectile dysfunction patients. Journal of Urological Surgery, 4, 4, 189-194.
