Evaluation of serum RANTES levels in childhood asthma
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Tarih
2012
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Giriş: İnflamatuvar hücreler için kemoatraktan
bir molekül olan RANTES, değişik allerjik hastalıklarda rol oynar. Bu çalışmanın amacı, çocukluk çağı astımında serum RANTES düzeylerini değerlendirmek ve akut astım atağındaki değişimini incelemektir.
Gereç ve Yöntem: Serum RANTES düzeyleri yaşları 2-14 yıl arasında olan 16 astımlı çocukta (median yaş: 4.5 yıl) akut astım atağı sırasında ve astım
atağından iki hafta sonra ELISA yöntemiyle ölçüldü. Yaş grubu benzer 10 sağlıklı çocuk da kontrol
grubunu oluşturdu.
Bulgular: Astımlı çocukların atak sırasında ölçülen serum RANTES düzeyleri kontrol grubu ile benzerken, atak sonrası ikinci haftada kontrol grubundan yüksek bulundu (p> 0.05). Astımlı hastaların
11’inde atak sonrası serum RANTES düzeyleri yükselirken, dördünde düşme saptandı, birinde ise değişiklik gözlenmedi. Astımlı hastalarda gözlenen bu
değişiklik istatistiksel olarak anlamlı bulundu.
Sonuç: Akut astım atağı sonrası ikinci haftada gözlenen serum düzeylerindeki yükselme eğilimi, RANTES’in çocukluk çağı astımının patogenezinde rol
oynayabilen bir molekül olabileceği savını destelemektedir.
(Asthma Allergy Immunol 2012;10:78-83)
Objective: RANTES is considered to play an important role in various allergic disorders since it is a potent chemoattractant for inflammatory cells such as eosinophils, memory T cells and monocytes. The aim of this study is to determine serum RANTES levels and to assess whether or not it varies in acute attack in the children with asthma. Materials and Methods: Serum RANTES levels were measured in 16 asthmatic children (2 to 14 years of age, median 4.5 years) longitudinally during asthma attacks and two weeks later by ELISA technique. Ten healthy age-matched children without any atopic and infectious disease served as controls. Results: There was no significant difference in serum levels of RANTES between asthmatic patients with acute attacks and controls. Two weeks following the acute attack, the serum RANTES levels were higher than the controls, however the difference was insignificant. When we compared the serum RANTES levels of asthmatic patients during acute attack and two weeks following the acute attack, the serum RANTES levels were elevated in 11 asthmatic patients, decreased in four, and remained unchanged in one. This variation occurring among asthmatic acute attack versus stable asthmatic children was statistically significant (p< 0.05). Conclusion: The up-regulation in the production of RANTES detected in stable asthmatic children two weeks after the acute attack suggests that RANTES is a mediator in the pathogenesis of childhood asthma. (Asthma Allergy Immunol 2012;10:78-83)
Objective: RANTES is considered to play an important role in various allergic disorders since it is a potent chemoattractant for inflammatory cells such as eosinophils, memory T cells and monocytes. The aim of this study is to determine serum RANTES levels and to assess whether or not it varies in acute attack in the children with asthma. Materials and Methods: Serum RANTES levels were measured in 16 asthmatic children (2 to 14 years of age, median 4.5 years) longitudinally during asthma attacks and two weeks later by ELISA technique. Ten healthy age-matched children without any atopic and infectious disease served as controls. Results: There was no significant difference in serum levels of RANTES between asthmatic patients with acute attacks and controls. Two weeks following the acute attack, the serum RANTES levels were higher than the controls, however the difference was insignificant. When we compared the serum RANTES levels of asthmatic patients during acute attack and two weeks following the acute attack, the serum RANTES levels were elevated in 11 asthmatic patients, decreased in four, and remained unchanged in one. This variation occurring among asthmatic acute attack versus stable asthmatic children was statistically significant (p< 0.05). Conclusion: The up-regulation in the production of RANTES detected in stable asthmatic children two weeks after the acute attack suggests that RANTES is a mediator in the pathogenesis of childhood asthma. (Asthma Allergy Immunol 2012;10:78-83)
Açıklama
Anahtar Kelimeler
Asthma, Rantes, Childhood, Astım, Çocukluk
Kaynak
Astım Allerji İmmünoloji
WoS Q Değeri
Scopus Q Değeri
Cilt
10
Sayı
2
Künye
Reisli, İ., Doğu, E. F., İkincioğulları, K. A., Babacan, E. (2012). Evaluation of serum RANTES levels in childhood asthma. Astım Allerji İmmünoloji, 10, 2, 78-83.
