The role of soluble urokinase plasminogen activator receptor (SuPAR) as an indicator of the severity of acute pancreatitis

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dc.authoridKadir Küçükceran: 0000-0001-9758-0803en_US
dc.authoridMehmet Ergin: 0000-0002-9420-6514en_US
dc.authoridİbrahim Kılınç: 0000-0002-7729-7557en_US
dc.authoridAdnan Karaibrahimoğlu: 0000-0002-8277-0281en_US
dc.authoridTamer Çolak: 0000-0003-3844-4785en_US
dc.authoridAlpay Tuncar: 0000-0002-3889-819Xen_US
dc.authoridZerrin Defne Dündar: 0000-0001-6431-5800en_US
dc.authoridSedat Koçak: 0000-0001-8265-9615en_US
dc.authoridAbdullah Sadık Girişgin: 0000-0003-2669-0532en_US
dc.authoridMehmet Gül: 0000-0003-3815-1667en_US
dc.authoridBaşar Cander: 0000-0003-1035-1907en_US
dc.contributor.authorKüçükceran, Kadir
dc.contributor.authorErgin, Mehmet
dc.contributor.authorKılınç, İbrahim
dc.contributor.authorKaraibrahimoğlu, Adnan
dc.contributor.authorÇolak, Tamer
dc.contributor.authorTuncar, Alpay
dc.contributor.authorDündar, Zerrin Defne
dc.contributor.authorKoçak, Sedat
dc.contributor.authorGirişgin, Abdullah Sadık
dc.contributor.authorGül, Mehmet
dc.contributor.authorCander, Başar
dc.date.accessioned2020-01-18T21:04:36Z
dc.date.available2020-01-18T21:04:36Z
dc.date.issued2018
dc.departmentNEÜ, Meram Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Acil Tıp Anabilim Dalıen_US
dc.departmentNEÜ, Meram Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyoistatistik ve Tıbbi Bilişim Anabilim Dalıen_US
dc.departmentNEÜ, Meram Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Anabilim Dalıen_US
dc.descriptionWOS:000452890300015en_US
dc.descriptionPubMed ID:30541244en_US
dc.description.abstractBackground/aim: Soluble urokinase plasminogen activator receptor (suPAR) has been reported to have a positive correlation with theactivation degree of the immune system. This study’s aim is to investigate the efficiency of SuPAR serum levels in acute pancreatitis (AP)patients in determining the severity of disease.Materials and methods: This prospective research involves patients who arrived at the emergency service, were over 18 years old, hadnontraumatic abdominal pain and diagnosis of AP, and agreed to join the study. Demographic characteristics, contact information,laboratory and imaging test parameters, Ranson’s criteria, the Balthazar Severity Index, the Rapid Acute Physiologic Score (RAPS), andthe modified Glasgow (Imrie) score of all patients were recorded. Two study groups were created as score of 3 (mild, Group I) and 3(severe, Group II) for pancreatitis according to Ranson’s criteria.Results: During the study period, 59 sequential patients with AP were included in the study. It was seen that 79.7% of the study group(n 47) were in Group I. Etiologically 67.8% (n 40) cases were biliary and 32.3% (n 19) were nonbiliary diseases. According to theresults, suPAR level was effective in distinguishing the severity of AP (AUC 0.902, P 0.001 (95% CI: 0.821–0.984)). With regardto determining severe disease, suPAR had an optimum cutoff value of 6.815 ng/mL, sensitivity of 91.66%, specificity of 82.97%, andnegative predictive value of 97.5%.Conclusion: Our study was performed the determine the efficiency of suPAR level in predicting severe disease in AP patients. We foundit significant in indicating the severity of disease according to the study results.en_US
dc.identifier.citationKüçükceran, K., Ergin, M., Kılınç, I., Karaibrahimoğlu, A., Çolak, T., Tuncar, A., Dündar, Z. D., Koçak, S., Girisgin, A. S., Gül, M., Cander, B. (2018). The role of soluble urokinase plasminogen activator receptor (SuPAR) as an indicator of the severity of acute pancreatitis. Turkish Journal of Medical Sciences, 48, 6, 1175-1181.en_US
dc.identifier.doi10.3906/sag-1709-134en_US
dc.identifier.endpage1181en_US
dc.identifier.issn1300-0144en_US
dc.identifier.issn1303-6165en_US
dc.identifier.issue6en_US
dc.identifier.pmid30541244en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1175en_US
dc.identifier.urihttps://dx.doi.org/10.3906/sag-1709-134
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TWprNE9EWTNOdz09/the-role-of-soluble-urokinase-plasminogen-activator-receptor-supar-as-an-indicator-of-the-severity-of-acute-pancreatitis
dc.identifier.urihttps://hdl.handle.net/20.500.12452/1872
dc.identifier.volume48en_US
dc.identifier.wosWOS:000452890300015en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US]
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcute pancreatitisen_US
dc.subjectBiomarkeren_US
dc.subjectAbdominal painen_US
dc.subjectSuparen_US
dc.titleThe role of soluble urokinase plasminogen activator receptor (SuPAR) as an indicator of the severity of acute pancreatitisen_US
dc.typeArticleen_US

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