Dynamic thiol-disulfide homeostasis is disturbed in hepatitis B virus-related chronic hepatitis and liver cirrhosis

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dc.authoridMuharrem Keskin: 0000-0002-5696-4752en_US
dc.authoridHüseyin Ataseven: 0000-0001-8515-8760en_US
dc.authoridPembe Oltulu: 0000-0003-3273-671Xen_US
dc.authoridMehmet Asıl: 0000-0001-7332-686Xen_US
dc.authoridHakkı Polat: 0000-0002-8532-237Xen_US
dc.authoridAli Demir: 0000-0002-2113-4484en_US
dc.authoridRamazan Dertli: 0000-0002-6205-8983en_US
dc.authoridMurat Bıyık: 0000-0003-0558-2882en_US
dc.contributor.authorDertli, Ramazan
dc.contributor.authorKeskin, Muharrem
dc.contributor.authorBıyık, Murat
dc.contributor.authorAtaseven, Hüseyin
dc.contributor.authorPolat, Hakkı
dc.contributor.authorDemir, Ali
dc.contributor.authorOltulu, Pembe
dc.contributor.authorAsıl, Mehmet
dc.date.accessioned2020-01-18T21:04:36Z
dc.date.available2020-01-18T21:04:36Z
dc.date.issued2018
dc.departmentNEÜ, Meram Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Anabilim Dalıen_US
dc.departmentNEÜ, Meram Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Tıbbi Patoloji Anabilim Dalıen_US
dc.descriptionWOS:000452889200014en_US
dc.descriptionPubMed ID:30384565en_US
dc.description.abstractBackground/aim: Thiol-disulfide homeostasis is an important antioxidant defense mechanism. This study was conducted to investigatedynamic thiol-disulfide homeostasis in patients with hepatitis B virus-related chronic hepatitis and liver cirrhosis.Materials and methods: Seventy-one treatment-naive patients with chronic hepatitis B (CHB), 50 patients with hepatitis B virusassociated liver cirrhosis, and 45 healthy controls were included in the study. Serum total and native thiol concentrations and serumdisulfide concentrations were measured using an automated method.Results: Mean serum total thiol concentrations in the control, CHB, and cirrhosis groups were 481.64 37.87 µmol/L, 438.50 71.35µmol/L, and 358.07 80.47 µmol/L, respectively (P 0.001), and mean serum native thiol concentrations in the control, CHB, andcirrhosis groups were 452.92 36.43 µmol/L, 400.16 65.92 µmol/L, and 328.15 74.91 µmol/L, respectively (P 0.001). Mean serumdisulfide concentrations in the control, CHB, and cirrhosis groups were 14.38 3.38 µmol/L, 19.19 6.16 µmol/L, and 14.98 5.53µmol/L, respectively (P 0.001). There was a progressive decrease in both mean serum native and total thiol concentrations parallel tothe liver fibrosis stage.Conclusion: : Thiol-disulfide homeostasis is disturbed in patients with hepatitis B virus-related chronic hepatitis and liver cirrhosis.en_US
dc.identifier.citationDertli, R., Keskin, M., Bıyık, M., Ataseven, H., Polat, H., Demir, A., Oltulu, P., Asıl, M., Neşeloğlu, S., Erel, Ö. (2018). Dynamic thiol-disulfide homeostasis is disturbed in hepatitis B virus-related chronic hepatitis and liver cirrhosis. Turkish Journal of Medical Sciences, 48, 5, 985-992.en_US
dc.identifier.doi10.3906/sag-1803-135en_US
dc.identifier.endpage992en_US
dc.identifier.issn1300-0144en_US
dc.identifier.issn1303-6165en_US
dc.identifier.issue5en_US
dc.identifier.pmid30384565en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage985en_US
dc.identifier.urihttps://dx.doi.org/10.3906/sag-1803-135
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TWprNU5EZzRPQT09/dynamic-thiol-disulfide-homeostasis-is-disturbed-in-hepatitis-b-virus-related-chronic-hepatitis-and-liver-cirrhosis
dc.identifier.urihttps://hdl.handle.net/20.500.12452/1873
dc.identifier.volume48en_US
dc.identifier.wosWOS:000452889200014en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US]
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHepatitis Ben_US
dc.subjectThiolsen_US
dc.subjectDisulfidesen_US
dc.subjectOxidative stressen_US
dc.titleDynamic thiol-disulfide homeostasis is disturbed in hepatitis B virus-related chronic hepatitis and liver cirrhosisen_US
dc.typeArticleen_US

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