The Effects of Sugammadex on Progesterone Levels in Pregnant Rats

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dc.authoridTayfun Et: 0000-0002-0111-3360
dc.authoridAtilla Erol: 0000-0002-2376-2759
dc.authoridAybars Tavlan: 0000-0002-6064-0179
dc.authoridAlper Kılıçaslan: 0000-0002-2570-5854
dc.authoridSema Tuncer Uzun: 0000-0002-6205-1706
dc.contributor.authorEt, Tayfun
dc.contributor.authorTopal, Ahmet
dc.contributor.authorErol, Atilla
dc.contributor.authorTavlan, Aybars
dc.contributor.authorKılıçaslan, Alper
dc.contributor.authorTuncer Uzun, Sema
dc.date.accessioned2020-01-18T21:02:52Z
dc.date.available2020-01-18T21:02:52Z
dc.date.issued2015
dc.departmentNEÜ, Meram Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Anesteziyoloji ve Reanimasyon Anabilim Dalıen_US
dc.description.abstractBackground: Sugammadex has been shown to de- crease the efficiency of progesterone-containing oral contraceptive drugs which possess a steroid structure. Aims: The aim of the present study was to evaluate the effects of sugammadex on progesterone levels in pregnant rats as well as on the physiological course of the pregnancy. Study Design: Animal experiment. Methods: This study was approved by the Selçuk Uni- versity Ethical Committee for Experimental Animal Research. Pregnant Winster Albino rats (n26) were divided into three groups and administered with vari- ous intravenous injections on the 7th day of pregnancy. The control group (Group K, n6) received 1.5 mL serum physiologic, the sugammadex group (Group S, n10) received 30 mg/kg sugammadex and the sugam- madex rocuronium group (Group SR, n10) received 30 mg/kg sugammadex and 3.5 mg/kg rocuronium. Progesterone levels were measured and the offspring were monitored for morphologic status. Results: Mean progesterone levels were 94.16±15.54 ng/mL in Group K, 87.86±12.48 ng/mL in Group S, and 94.53±16.10 ng/mL in Group SR (p<0.05). No stillbirth or miscarriage was observed in the rats. The mean number of offspring was 6.8±1.47 in Group K, 6.5±1.35 in Group S, and 6.4±1.17 in Group SR. The offspring appeared macroscopically normal. Conclusion: Sugammadex does not appear to affect the progesterone levels in pregnant rats in the first trimes- ter and the clinical course. Successful completion of pregnancy and the absence of stillbirth or miscarriage will guide future studies about the use of sugammadex, particularly in the first trimester of the pregnancy.en_US
dc.identifier.citationEt, T., Topal, A., Erol, A., Tavlan, A., Kılıçaslan, A., Tuncer Uzun, S. (2015). The Effects of sugammadex on progesterone levels in pregnant rats. Balkan Medical Journal, 32, 2, 203-207.
dc.identifier.doi10.5152/balkanmedj.2015.15502en_US
dc.identifier.endpage207en_US
dc.identifier.issn2146-3123en_US
dc.identifier.issn2146-3131en_US
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage203en_US
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TVRjeE9UYzFOUT09/the-effects-of-sugammadex-on-progesterone-levels-in-pregnant-rats
dc.identifier.urihttps://hdl.handle.net/20.500.12452/1333
dc.identifier.volume32en_US
dc.identifier.wosWOS:000353479200010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofBalkan Medical Journalen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US]
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPregnanten_US
dc.subjectProgesterone levelen_US
dc.subjectRaten_US
dc.subjectSugammadexen_US
dc.titleThe Effects of Sugammadex on Progesterone Levels in Pregnant Ratsen_US
dc.typeArticleen_US

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