Turner Syndrome and Associated Problems in Turkish Children: A Multicenter Study

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dc.authorid0000-0002-2242-9401en_US
dc.contributor.authorYeşilkaya, Ediz
dc.contributor.authorBereket, Abdullah
dc.contributor.authorDarendeliler, Fatma Feyza
dc.contributor.authorBaş, Firdevs
dc.contributor.authorPoyrazoğlu, Şükran
dc.contributor.authorKüçükemre Aydın, Banu
dc.contributor.authorDarcan, Şükran
dc.contributor.authorDündar, Bumin Nuri
dc.contributor.authorBüyükinan, Muammer
dc.contributor.authorKara, Cengiz
dc.contributor.authorSarı, Erkan
dc.contributor.authorAdal, Servet Erdal
dc.contributor.authorAkıncı, Ayşehan
dc.contributor.authorAtabek, Mehmet Emre
dc.contributor.authorDemirel, Fatma
dc.contributor.authorÇelik, Nurullah
dc.contributor.authorÖzkan, Behzat
dc.contributor.authorOrbak, Zerrin
dc.contributor.authorErsoy, Betül
dc.contributor.authorDoğan, Murat
dc.contributor.authorAtaş, Ali
dc.contributor.authorTuran, Serap
dc.contributor.authorGökşen Şimşek, Ruhsar Damla
dc.contributor.authorTarım, Ömer Faruk
dc.contributor.authorYüksel, Bilgin
dc.contributor.authorErcan, Oya
dc.contributor.authorHatun, Şükrü
dc.contributor.authorŞimşek, Enver
dc.contributor.authorÖkten, Ayşenur
dc.contributor.authorAbacı, Ayhan
dc.contributor.authorDöneray, Hakan
dc.contributor.authorÖzbek, Mehmet Nuri
dc.contributor.authorKeskin, Mehmet
dc.contributor.authorÖnal, Hasan
dc.contributor.authorAkyürek, Nesibe
dc.contributor.authorBulan, Kezban
dc.contributor.authorTepe, Derya
dc.contributor.authorEmeksiz, Hamdi Cihan
dc.contributor.authorDemir, Korcan
dc.contributor.authorKızılay, Deniz
dc.contributor.authorTopaloğlu, Ali Kemal
dc.contributor.authorEren, Erdal
dc.contributor.authorÖzen, Samim
dc.contributor.authorAbalı, Saygın
dc.contributor.authorAkın, Leyla
dc.contributor.authorSelver Eklioğlu, Beray
dc.contributor.authorKaba, Sultan
dc.contributor.authorAnık, Ahmet
dc.contributor.authorBaş, Serpil
dc.contributor.authorÜnüvar, Tolga
dc.contributor.authorSağlam, Halil
dc.contributor.authorBolu, Semih
dc.contributor.authorÖzgen, İlker Tolga
dc.contributor.authorDoğan, Durmuş
dc.contributor.authorÇakır, Esra Deniz
dc.contributor.authorŞen, Yaşar
dc.contributor.authorAndıran, Nesibe
dc.contributor.authorÇizmecioğlu, Filiz Mine
dc.contributor.authorEvliyaoğlu, Saadet Olcay
dc.contributor.authorKaragüzel, Gülay
dc.contributor.authorPirgon, Mustafa Özgür
dc.contributor.authorÇatlı, Gönül
dc.contributor.authorCan, Hatice Dilek
dc.contributor.authorGürbüz, Fatih
dc.contributor.authorBinay, Çiğdem
dc.contributor.authorBaş, Veysel Nijat
dc.contributor.authorFidancı, Muzaffer Kürşat
dc.contributor.authorPolat, Adem
dc.contributor.authorGül, Davut
dc.contributor.authorAçıkel, Cengizhan
dc.contributor.authorDemirbilek, Hüseyin
dc.contributor.authorCinaz, Peyami
dc.contributor.authorBondy, Carolyn
dc.date.accessioned2020-01-18T21:02:58Z
dc.date.available2020-01-18T21:02:58Z
dc.date.issued2015
dc.departmentNEÜ, Meram Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalığı Anabilim Dalıen_US
dc.description.abstractObjective: Turner syndrome (TS) is a chromosomal disorder caused by complete or partial X chromosome monosomy that manifests various clinical features depending on the karyotype and on the genetic background of affected girls. This study aimed to systematically investigate the key clinical features of TS in relationship to karyotype in a large pediatric Turkish patient population.Methods: Our retrospective study included 842 karyotype-proven TS patients aged 0-18 years who were evaluated in 35 different centers in Turkey in the years 2013-2014.Results: The most common karyotype was 45,X (50.7%), followed by 45,X/46,XX (10.8%), 46,X,i(Xq) (10.1%) and 45,X/46,X,i(Xq) (9.5%). Mean age at diagnosis was 10.2±4.4 years. The most common presenting complaints were short stature and delayed puberty. Among patients diagnosed before age one year, the ratio of karyotype 45,X was significantly higher than that of other karyotype groups. Cardiac defects (bicuspid aortic valve, coarctation of the aorta and aortic stenosis) were the most common congenital anomalies, occurring in 25% of the TS cases. This was followed by urinary system anomalies (horseshoe kidney, double collector duct system and renal rotation) detected in 16.3%. Hashimoto's thyroiditis was found in 11.1% of patients, gastrointestinal abnormalities in 8.9%, ear nose and throat problems in 22.6%, dermatologic problems in 21.8% and osteoporosis in 15.3%. Learning difficulties and/or psychosocial problems were encountered in 39.1%. Insulin resistance and impaired fasting glucose were detected in 3.4% and 2.2%, respectively. Dyslipidemia prevalence was 11.4%.Conclusion: This comprehensive study systematically evaluated the largest group of karyotype-proven TS girls to date. The karyotype distribution, congenital anomaly and comorbidity profile closely parallel that from other countries and support the need for close medical surveillance of these complex patients throughout their lifespanen_US
dc.identifier.citationYeşilkaya, E., Bereket, A., Darendeliler, F., Baş, F., Poyrazoğlu, S., Aydın, B. K., Darcan, S., Eklioğlu, B. S., Atabek, M. E., Akyürek, N., ... Bondy, C. (2015). Turner Syndrome and Associated Problems in Turkish Children: A Multicenter Study. Journal of Clinical Research in Pediatric Endocrinology, 7, 1, 27-36.en_US
dc.identifier.doi10.4274/jcrpe.1771en_US
dc.identifier.endpage36en_US
dc.identifier.issn1308-5727en_US
dc.identifier.issn1308-5735en_US
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage27en_US
dc.identifier.urihttp://app.trdizin.gov.tr/publication/paper/detail/TVRrNU1EYzRPQT09
dc.identifier.urihttps://hdl.handle.net/20.500.12452/1393
dc.identifier.volume7en_US
dc.identifier.wosWOS:000351307200005en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofJournal of Clinical Research in Pediatric Endocrinologyen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US]
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEndokrinoloji ve Metabolizmaen_US
dc.subjectPediatrien_US
dc.subjectNationwide Studyen_US
dc.subjectTurner Syndromeen_US
dc.subjectChildrenen_US
dc.subjectDiagnostic Features
dc.subjectAssociated Problemsen_US
dc.titleTurner Syndrome and Associated Problems in Turkish Children: A Multicenter Studyen_US
dc.typeArticleen_US

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