The histopathological evaluation of healing effects of vitamin C administered before methotrexate therapy on testicular injury induced by methotrexate

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dc.authoridAydan Görgülü: 0000-0002-4267-6899en_US
dc.contributor.authorSayılmaz, Aysun
dc.contributor.authorKarabulut, Yasemin Yuyucu
dc.contributor.authorÖzgörgülü, Aydan
dc.date.accessioned2020-01-18T21:02:57Z
dc.date.available2020-01-18T21:02:57Z
dc.date.issued2016
dc.departmentNEÜ, Meram Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Anabilim Dalıen_US
dc.descriptionWOS:000388501500004en_US
dc.descriptionPubMed ID:27909615en_US
dc.description.abstractObjective: Methotrexate (MTX) leads to acute toxic side effects in tissues or organs containing rapidly dividing cells such as seminiferous tubules. In this study, we investigated the protective effects of vitamin C against MTX-induced injury in rat testis.Material and methods: A total of 31 rats were divided into 4 groups, including the control group. The study was completed within 4 weeks and the rats received daily doses of 2 mL/kg SF, 100 mg/kg vitamin C and 10 mg/kg/day MTX i.p according to their groups. The mean seminiferous tubular diameter, germinal epithelial cell thickness, and mean testicular biopsy score were determined by histologic examination of each group.Results: The vitamin C MTX group showed more similarity with the control group. Statistically significant results were achieved between groups as for mean seminiferous tubular diameter, germinal epithelial cell thickness, and mean testicular biopsy score. When compared with the group which received vitamin C after MTX therapy, values for mean seminiferous tubular diameter, germinal epithelial cell thickness, and mean testicular biopsy score were significantly higher in the group which received vitamin C before initiation of MTX therapy.Conclusion: Vitamin C decreased MTX-induced testicular histological injuries, especially when used before MTX therapy.en_US
dc.identifier.citationSayılmaz, A., Karabulut, Y. Y., Özgörgülü, A. (2016). The histopathological evaluation of healing effects of vitamin C administered before methotrexate therapy on testicular injury induced by methotrexate. Turkish Journal of Urology, 42, 4, 235-239.en_US
dc.identifier.doi10.5152/tud.2016.63903en_US
dc.identifier.endpage239en_US
dc.identifier.issn2149-3235en_US
dc.identifier.issn2149-3057en_US
dc.identifier.issue4en_US
dc.identifier.pmid27909615en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage235en_US
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TWpNNU5Ua3dNQT09/the-histopathological-evaluation-of-healing-effects-of-vitamin-c-administered-before-methotrexate-therapy-on-testicular-injury-induced-by-methotrexate
dc.identifier.urihttps://hdl.handle.net/20.500.12452/1381
dc.identifier.volume42en_US
dc.identifier.wosWOS:000388501500004en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Urologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US]
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectVitamin Cen_US
dc.subjectMethotrexateen_US
dc.subjectTestisen_US
dc.titleThe histopathological evaluation of healing effects of vitamin C administered before methotrexate therapy on testicular injury induced by methotrexateen_US
dc.typeArticleen_US

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