İmmünglobulin A eksikliğinde atopi ve allerjik hastalıklar
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Tarih
2012
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Dergi ISSN
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Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Giriş: İmmünglobulin (Ig) A eksikliği özellikle okul öncesi çocukluk çağında morbiditeye neden olan yaygın bir immün sistem bozukluğudur. Bu çalışmanın amacı, IgA eksikliği olan olguları atopi ve allerjik hastalık yönünden yaş gruplarına göre değerlendirmek, bu eksikliğin dört yaş altında ve üstündeki klinik sonuçlarını belirlemektir. Gereç ve Yöntem: Kasım 2001-2007 tarihleri arasında 272 parsiyel ve 23 selektif IgA eksikliği olan toplam 295 hasta retrospektif olarak incelendi. Bulgular: Hastaların tanı yaşları 64.3 43 (4-204) ay, infeksiyonların başlangıç yaşı 29.5 36 (1-168) ay idi. Tanı yaşı dört yaş altında 121 hasta mevcuttu. Başvuru sebepleri sırasıyla tekrarlayan bronşit (40), tonsillofarenjit (33), sinüzit (6), pnömoni (4), otit (2), akut gastroenterit (0.3) ve boyun apsesi (0.3) olarak kaydedildi. Olguların %25’inde eozinofili ve 38’inde artmış IgE düzeyi ve aralarında ilişki belirlendi. Hastaların 31’inde spesifik IgE ve/veya deri testi pozitifliğiyle atopi saptandı. Allerjik hastalık sıklığı 78 oranında bulundu (60 astım, 15 allerjik rinit, 8 atopik dermatit, 6 ürtiker, 0.7 allerjik konjunktivit). Klinik izlemde IgA düzeyinin normal sınırlara ulaşma zamanı 17 14 ay olup, 3-60 ay arasında değişmekteydi. Selektif IgA eksikliği olan üç hastada bronşektazi mevcuttu. Sonuç: Serum IgA düzeyi yalnızca tekrarlayan infeksiyon durumlarında değil, allerjik semptomlarla başvuran hastalarda da değerlendirilmelidir.
Objective: Immunoglobulin (Ig) A deficiency is a common immune system disorder which causes morbidity especially in preschool children. The aim of this study is to evaluate atopy and allergic diseases of cases with IgA deficiency, determinate clinical results before and after four years of age. Materials and Methods: The data records of 295 children with IgA deficiency (272 partial, 23 selective IgA deficiency) between November 2001 and 2007 were examined retrospectively. Results: The mean age at the diagnosis was 64.3 43 (4-204) months, the mean age at the beginning of infection was 29.5 36 (1-168) months. There were 121 patients under the age of four years at the diagnosis time. The clinical presentations were recurrent bronchitis (40), tonsillitis/ pharyngitis (33), sinusitis (6), pneumonia (4), acute otitis media (2), acute gastroenteritis (0.3) and neck abscess (0.3), respectively. Eosinophilia was present in 25 of patients, increased IgE levels was present in 38 of patients, and they were correlated with each other. Atopy was detected in 31 of patients by spesific IgE and/or skin prick test positivity. Allergic disease prevalance was found as 78 (60 asthma, 15 allergic rhinitis, 8 atopic dermatitis, 6 urticaria, 0.7 allergic conjunctivitis). During the clinical followup IgA levels reached to normal levels at 17 14 months ranged between 3 and 60 months. Three patients with selective IgA deficiency had bronchiectasia. Conclusion: We found that allergic diseases were increased in these patients. Serum IgA level should be tested not only for recurrent infections but also for patients with allergic symptoms.
Objective: Immunoglobulin (Ig) A deficiency is a common immune system disorder which causes morbidity especially in preschool children. The aim of this study is to evaluate atopy and allergic diseases of cases with IgA deficiency, determinate clinical results before and after four years of age. Materials and Methods: The data records of 295 children with IgA deficiency (272 partial, 23 selective IgA deficiency) between November 2001 and 2007 were examined retrospectively. Results: The mean age at the diagnosis was 64.3 43 (4-204) months, the mean age at the beginning of infection was 29.5 36 (1-168) months. There were 121 patients under the age of four years at the diagnosis time. The clinical presentations were recurrent bronchitis (40), tonsillitis/ pharyngitis (33), sinusitis (6), pneumonia (4), acute otitis media (2), acute gastroenteritis (0.3) and neck abscess (0.3), respectively. Eosinophilia was present in 25 of patients, increased IgE levels was present in 38 of patients, and they were correlated with each other. Atopy was detected in 31 of patients by spesific IgE and/or skin prick test positivity. Allergic disease prevalance was found as 78 (60 asthma, 15 allergic rhinitis, 8 atopic dermatitis, 6 urticaria, 0.7 allergic conjunctivitis). During the clinical followup IgA levels reached to normal levels at 17 14 months ranged between 3 and 60 months. Three patients with selective IgA deficiency had bronchiectasia. Conclusion: We found that allergic diseases were increased in these patients. Serum IgA level should be tested not only for recurrent infections but also for patients with allergic symptoms.
Açıklama
Anahtar Kelimeler
İmmünglobulin A eksikliği, Atopi, Allerjik hastalık, Immunoglobulin A deficiency, Atopy, Allergic disease
Kaynak
Astım Allerji İmmünoloji
WoS Q Değeri
Scopus Q Değeri
Cilt
10
Sayı
1
Künye
Keleş, S., Reisli, İ., Artaç, H., Karagöl, C., Göktürk, B. (2012). İmmünglobulin A eksikliğinde atopi ve allerjik hastalıklar. Astım Allerji İmmünoloji, 10, 1, 25-30.
