Routinely evaluated clinical assays and laboratory tests [real test] and fibrosis stages of chronic hepatitis B and C

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dc.authoridHüseyin Korkmaz: 0000-0002-0571-0402
dc.authoridTuncer Temel: 0000-0002-4525-2936
dc.authoridAyşegül Özakyol: 0000-0003-0152-8651
dc.authoridHakan Şentürk: 0000-0002-2440-4478
dc.contributor.authorDemir, Ali
dc.contributor.authorBıyık, Murat
dc.contributor.authorBuğdacı, Mehmet Sait
dc.contributor.authorKorkmaz, Hüseyin
dc.contributor.authorTemel, Tuncer
dc.contributor.authorGöktürk, Hüseyin Savaş
dc.contributor.authorÖzakyol, Ayşegül
dc.contributor.authorHatemi, İbrahim
dc.contributor.authorBaysal, Birol
dc.contributor.authorKaraca, Çetin
dc.contributor.authorŞentürk, Hakan
dc.date.accessioned2020-01-18T21:02:52Z
dc.date.available2020-01-18T21:02:52Z
dc.date.issued2014
dc.departmentNEÜ, Meram Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Anabilim Dalıen_US
dc.description.abstractBackground/Aims: To provide a new mathematical formula to predict liver fibrosis in patients with chronic viral hepatitis. Materials and Methods: Patients with chronic hepatitis B and C who underwent liver biopsy at different centers were included in this study. Chronic hepatitis B was defined as immunopositivity for the hepatitis B surface antigen for at least 6 months, and chronic hepatitis C was defined as positivity for HCV RNA for at least 3 months. The histological features were evaluated by the histological activity index and fibrosis. Results: In total, 1299 patients were included in the study. The distribution and the mean of the parameters of the patients were as follows: 1009 patients with chronic hepatitis B with a mean age of 45±13/years [emale/male (F/M)47.5/52.5%] and 290 patients with hepatitis C with a mean age of 52±cut-off value of the REAL TEST formula&quot;[(age x pT x AST)/(PLT/1000)]/100&quot; in patients with hepatitis B was determined to be <1.37, it was found that it could predict fibrosis with 79% specificity, 78% sensitivity, 85% negative predictive value (NPV), and 70% positive predictive value (PPV) (area under the curve (AUC)0.852, 95% CI:0.820.87). When the cut-off value of the REAL TEST formula in patients with hepatitis C was determined to be <1.99, it was found that it could predict significant fibrosis with 87% specificity, 90% sensitivity, 94.4% NPV, and 79.4% PPV (AUC:0.95, 95% CI:0.93-0.98) Conclusion: The REAL TEST formula results correlated with the pathological findings and may be a useful method for the evaluation of patients with chronic hepatitis B and C.en_US
dc.identifier.citationDemir, A., Bıyık, M., Buğdacı, M. S., Korkmaz, H., Temel, T., Göktürk, H. S., Özakyol, A., Hatemi, İ., Baysal, B., Karaca, Ç., Şentürk, H. (2014). Routinely evaluated clinical assays and laboratory tests [real test] and fibrosis stages of chronic hepatitis B and C. Turkish Journal of Gastroenterology, 25, 5, 539-545.
dc.identifier.doi10.5152/tjg.2014.6170en_US
dc.identifier.endpage545en_US
dc.identifier.issn1300-4948en_US
dc.identifier.issn2148-5607en_US
dc.identifier.issue5en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage539en_US
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TWpJeE1qYzFOUT09/routinely-evaluated-clinical-assays-and-laboratory-tests-real-test-and-fibrosis-stages-of-chronic-hepatitis-b-and-c
dc.identifier.urihttps://hdl.handle.net/20.500.12452/1332
dc.identifier.volume25en_US
dc.identifier.wosWOS:000345023700012en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Gastroenterologyen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US]
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectChronic hepatitisen_US
dc.subjectREAL TESTen_US
dc.subjectRoutine laboratory testsen_US
dc.subjectFibrosisen_US
dc.titleRoutinely evaluated clinical assays and laboratory tests [real test] and fibrosis stages of chronic hepatitis B and Cen_US
dc.typeArticleen_US

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