Ambulatory Blood Pressure and Subclinical Cardiovascular Disease in Patients with Congenital Adrenal Hyperplasia: A Preliminary Report
Yükleniyor...
Dosyalar
Tarih
2015
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: There is an increased risk of cardiovascular morbidity in children and adolescents with classical congenital adrenal hyperplasia (CAH), presumably associated with obesity, hypertension, impaired glucose tolerance and dyslipidemia. This study was designed to evaluate the metabolic and cardiovascular profile of a group of children with classical CAH from the perspective of cardiovascular risk.Methods: Twenty-five CAH patients and 25 healthy controls were included in the study. Metabolic and anthropometric parameters were investigated and compared in these two groups. Results: Subjects in the CAH group were shorter than the controls (p0.001) and had higher body mass index values (p0.033). Diastolic blood pressure (DBP) (p0.027) and carotid intima-media thickness (CIMT) values (p0.006) were also higher in the patient group. In 24% (n6) of CAH patients, 24-h ambulatory BP monitoring showed arterial hypertension. CIMT was significantly higher in the hypertensive patients than in those with no hypertension (p0.013). Twenty percent (n5) of CAH patients had nocturnal hypertension. CIMT was significantly greater in the nocturnal hypertensive group (p0.02). Mean systolic BP (SBP) and DBP dipping were significantly different in the CAH patients (p>0.001). CIMT correlated negatively with DBP dipping (r-0632, p0.037) in these patients.Conclusion: These results provide additional evidence for the presence of subclinical cardiovascular disease in classical CAH patients and its relationship with hypertension
Açıklama
Anahtar Kelimeler
Endokrinoloji ve Metabolizma, Pediatri, Subclinical Cardiovascular Disease, Congenital Adrenal Hyperplasia, Ambulatory Blood Pressure
Kaynak
Journal of Clinical Research in Pediatric Endocrinology
WoS Q Değeri
Q2
Scopus Q Değeri
Q2
Cilt
7
Sayı
1
Künye
Akyürek, N., Atabek, M. E., Eklioğlu, B S., Alp, H. (2015). Ambulatory Blood Pressure and Subclinical Cardiovascular Disease in Patients with Congenital Adrenal Hyperplasia: A Preliminary Report. Journal of Clinical Research in Pediatric Endocrinology, 7, 1, 13-18.
