Ambulatory Blood Pressure and Subclinical Cardiovascular Disease in Patients with Congenital Adrenal Hyperplasia: A Preliminary Report

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dc.authorid0000-0002-2242-9401en_US
dc.contributor.authorAkyürek, Nesibe
dc.contributor.authorAtabek, Mehmet Emre
dc.contributor.authorEklioğlu, Beray Selver
dc.contributor.authorAlp, Hayrullah
dc.date.accessioned2020-01-18T21:02:58Z
dc.date.available2020-01-18T21:02:58Z
dc.date.issued2015
dc.departmentNEÜ, Meram Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalığı Anabilim Dalıen_US
dc.description.abstractObjective: There is an increased risk of cardiovascular morbidity in children and adolescents with classical congenital adrenal hyperplasia (CAH), presumably associated with obesity, hypertension, impaired glucose tolerance and dyslipidemia. This study was designed to evaluate the metabolic and cardiovascular profile of a group of children with classical CAH from the perspective of cardiovascular risk.Methods: Twenty-five CAH patients and 25 healthy controls were included in the study. Metabolic and anthropometric parameters were investigated and compared in these two groups. Results: Subjects in the CAH group were shorter than the controls (p0.001) and had higher body mass index values (p0.033). Diastolic blood pressure (DBP) (p0.027) and carotid intima-media thickness (CIMT) values (p0.006) were also higher in the patient group. In 24% (n6) of CAH patients, 24-h ambulatory BP monitoring showed arterial hypertension. CIMT was significantly higher in the hypertensive patients than in those with no hypertension (p0.013). Twenty percent (n5) of CAH patients had nocturnal hypertension. CIMT was significantly greater in the nocturnal hypertensive group (p0.02). Mean systolic BP (SBP) and DBP dipping were significantly different in the CAH patients (p>0.001). CIMT correlated negatively with DBP dipping (r-0632, p0.037) in these patients.Conclusion: These results provide additional evidence for the presence of subclinical cardiovascular disease in classical CAH patients and its relationship with hypertensionen_US
dc.identifier.citationAkyürek, N., Atabek, M. E., Eklioğlu, B S., Alp, H. (2015). Ambulatory Blood Pressure and Subclinical Cardiovascular Disease in Patients with Congenital Adrenal Hyperplasia: A Preliminary Report. Journal of Clinical Research in Pediatric Endocrinology, 7, 1, 13-18.en_US
dc.identifier.doi10.4274/jcrpe.1658en_US
dc.identifier.endpage18en_US
dc.identifier.issn1308-5727en_US
dc.identifier.issn1308-5735en_US
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage13en_US
dc.identifier.urihttp://app.trdizin.gov.tr/publication/paper/detail/TVRrNU1EYzJOZz09
dc.identifier.urihttps://hdl.handle.net/20.500.12452/1390
dc.identifier.volume7en_US
dc.identifier.wosWOS:000351307200003en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofJournal of Clinical Research in Pediatric Endocrinologyen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US]
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEndokrinoloji ve Metabolizmaen_US
dc.subjectPediatrien_US
dc.subjectSubclinical Cardiovascular Diseaseen_US
dc.subjectCongenital Adrenal Hyperplasiaen_US
dc.subjectAmbulatory Blood Pressureen_US
dc.titleAmbulatory Blood Pressure and Subclinical Cardiovascular Disease in Patients with Congenital Adrenal Hyperplasia: A Preliminary Reporten_US
dc.typeArticleen_US

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