Detection Of The Frequency Of Per-1 Type Extended-Spectrum Β-Lactamase Producing Acinetobacter Baumannii Clinical İsolates İn Turkey: A Multicenter Study
Yükleniyor...
Dosyalar
Tarih
2014
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Background/aim: β-Lactamases are an important resistance mechanism in Acinetobacter baumannii. Pseudomonas extended-resistance (PER-1) type β-lactamaseproducing strains have been reported from various geographic locations; however, PER-1 type β-lactamases from Turkish hospitals have not been investigated extensively. The aim of this study was to determine the prevalence of PER-1 type β-lactamases in A. baumannii isolates in various regions of Turkey. Materials and methods: A total of 763 clinical A. baumannii isolates were collected from 9 university hospitals and 2 state hospitals between 2008 and 2011. Molecular amplification of the OXA-51 gene from the A. baumannii genome was performed in order to verify identification of the species. Real-time polymerase chain reaction was used to detect blaPER-1 genes. Results: PER-1 was detected in 24.6% of the isolates. The annual frequencies of the PER-1 enzyme were detected as 52.2%, 35.9%, and 8.3% in 2008, 2009, and 2010, respectively. PER-1 prevalence decreased gradually over time. The differences observed in PER-1 prevalence among the regions of Turkey were statistically significant (chi-square test; P > 0.001). Conclusion: These data demonstrate that the frequency of detection of PER-1 type β-lactamases in A. baumannii species has decreased in Turkey. However, the increased carbapenem resistance, together with multidrug resistance, has created a worrisome situation regarding this pathogen.
Açıklama
Anahtar Kelimeler
Cerrahi, Acinetobacter Baumannii, β-lactamases, PER-1
Kaynak
Turkish Journal of Medical Sciences
WoS Q Değeri
Scopus Q Değeri
Q3
Cilt
44
Sayı
6
Künye
Aşık, G., Özdemir, M., Kurtoğlu, M G., Yağcı, S., Öksüz, L., Gül, M., Koçoğlu, M E., Sesli Çetin, E., Seyrek, A., Berktaş, M., Ayyıldız, A., Çiftçi, İ H. (2014). Detection Of The Frequency Of Per-1 Type Extended-Spectrum Β-Lactamase Producing Acinetobacter Baumannii Clinical İsolates İn Turkey: A Multicenter Study. Turkish Journal of Medical Sciences. 44, 6, 1041 - 1046.
