Detection Of The Frequency Of Per-1 Type Extended-Spectrum Β-Lactamase Producing Acinetobacter Baumannii Clinical İsolates İn Turkey: A Multicenter Study

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dc.authorid0000-0002-9316-771Xen_US
dc.contributor.authorAşık, Gülşah
dc.contributor.authorÖzdemir, Mehmet
dc.contributor.authorKurtoğlu, Mehmet Güzel
dc.contributor.authorYağcı, Server
dc.contributor.authorÖksüz, Lütfiye
dc.contributor.authorGül, Mustafa
dc.contributor.authorKoçoğlu, Mücahide Esra
dc.contributor.authorSesli Çetin, Emel
dc.contributor.authorSeyrek, Adnan
dc.contributor.authorBerktaş, Mustafa
dc.contributor.authorAyyıldız, Ahmet
dc.contributor.authorÇiftçi, İhsan Hakkı
dc.date.accessioned2020-01-18T21:02:51Z
dc.date.available2020-01-18T21:02:51Z
dc.date.issued2014
dc.departmentNEÜ, Meram Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Mikrobiyoloji Anabilim Dalıen_US
dc.description.abstractBackground/aim: β-Lactamases are an important resistance mechanism in Acinetobacter baumannii. Pseudomonas extended-resistance (PER-1) type β-lactamaseproducing strains have been reported from various geographic locations; however, PER-1 type β-lactamases from Turkish hospitals have not been investigated extensively. The aim of this study was to determine the prevalence of PER-1 type β-lactamases in A. baumannii isolates in various regions of Turkey. Materials and methods: A total of 763 clinical A. baumannii isolates were collected from 9 university hospitals and 2 state hospitals between 2008 and 2011. Molecular amplification of the OXA-51 gene from the A. baumannii genome was performed in order to verify identification of the species. Real-time polymerase chain reaction was used to detect blaPER-1 genes. Results: PER-1 was detected in 24.6% of the isolates. The annual frequencies of the PER-1 enzyme were detected as 52.2%, 35.9%, and 8.3% in 2008, 2009, and 2010, respectively. PER-1 prevalence decreased gradually over time. The differences observed in PER-1 prevalence among the regions of Turkey were statistically significant (chi-square test; P > 0.001). Conclusion: These data demonstrate that the frequency of detection of PER-1 type β-lactamases in A. baumannii species has decreased in Turkey. However, the increased carbapenem resistance, together with multidrug resistance, has created a worrisome situation regarding this pathogen.en_US
dc.identifier.citationAşık, G., Özdemir, M., Kurtoğlu, M G., Yağcı, S., Öksüz, L., Gül, M., Koçoğlu, M E., Sesli Çetin, E., Seyrek, A., Berktaş, M., Ayyıldız, A., Çiftçi, İ H. (2014). Detection Of The Frequency Of Per-1 Type Extended-Spectrum Β-Lactamase Producing Acinetobacter Baumannii Clinical İsolates İn Turkey: A Multicenter Study. Turkish Journal of Medical Sciences. 44, 6, 1041 - 1046.en_US
dc.identifier.endpage1046en_US
dc.identifier.issn1300-0144en_US
dc.identifier.issn1303-6165en_US
dc.identifier.issue6en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1041en_US
dc.identifier.urihttp://app.trdizin.gov.tr/publication/paper/detail/TWpFek1qSXdNQT09
dc.identifier.urihttps://hdl.handle.net/20.500.12452/1316
dc.identifier.volume44en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US]
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCerrahien_US
dc.subjectAcinetobacter Baumanniien_US
dc.subjectβ-lactamasesen_US
dc.subjectPER-1en_US
dc.titleDetection Of The Frequency Of Per-1 Type Extended-Spectrum Β-Lactamase Producing Acinetobacter Baumannii Clinical İsolates İn Turkey: A Multicenter Studyen_US
dc.typeArticleen_US

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