The Significance of Extent of Extracapsular Extension in Patients with T1-2 and N1 Breast Cancer
Yükleniyor...
Dosyalar
Tarih
2018
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: The prognostic importance of extracapsular extension (ECE) in breast cancer is not yet clear, especially in patients with pathologicalT1-2 and N1 (pT1-2N1) disease. We aimed to investigate whether the extent of ECE was an independent prognostic factor for survival outcomesin patients with pT1-2N1 breast cancer.Materials and Methods: A total number of 131 patients with pT1-2N1 breast cancer treated between 2009 and 2015 were retrospectively evaluated. A single pathologist re-analyzed the histologic examples of all cases. The extent of ECE was graded from 0 to 4.Results: There was a significant correlation between the number of lymph nodes involved and ECE grade (p0.004). According to the univariateanalysis, lymphovascular invasion (LVI) and ECE grade were the significant prognostic factors for overall survival (OS); age, number of metastaticlymph nodes, menopausal status, and ECE grade were the prognostic factors for disease-free survival (DFS). With a median follow-up of 46 months,grade 3-4 ECE seems to be notably associated with a shorter OS and DFS in multivariate analysis. The mean OS was 85 months for the patients withgrade 0-2 ECE vs 75 months for the patients with grade 3-4 ECE (p0.003). The mean DFS was 83 months for the patients with grade 0-3 ECE vs68 months for the patients with grade 4 ECE (p0.0001).Conclusion: This research has shown that the extent of ECE is an important prognostic factor for survival in pT1-2N1 breast cancer patients andgrade 3-4 ECE seems to be notably associated with a shorter OS and DFS.
Açıklama
WOS:000446223100006
PubMed ID:30288496
PubMed ID:30288496
Anahtar Kelimeler
Axillary lymph node metastases, Breast cancer, Extracapsular extension, Radiotherapy, Prognosis
Kaynak
European Journal of Breast Health
WoS Q Değeri
Scopus Q Değeri
Cilt
14
Sayı
4
Künye
Kanyılmaz, G., Fındık, S., Yavuz, B. B., Aktan, M. (2018). The significance of extent of extracapsular extension in patients with T1-2 and N1 breast cancer. European Journal of Breast Health, 14, 4, 218-224.
