The Significance of Extent of Extracapsular Extension in Patients with T1-2 and N1 Breast Cancer

Basit Öğe Kaydı
dc.authoridGül Kanyılmaz: 0000-0003-2333-353Xen_US
dc.authoridSıddıka Fındık: 0000-0002-3364-7498en_US
dc.authoridBerrin Benli Yavuz: 0000-0001-7816-4687en_US
dc.authoridMeryem Aktan: 0000-0002-0447-7784en_US
dc.contributor.authorKanyılmaz, Gül
dc.contributor.authorFındık, Sıddıka
dc.contributor.authorYavuz, Berrin Benli
dc.contributor.authorAktan, Meryem
dc.date.accessioned2020-01-18T21:12:15Z
dc.date.available2020-01-18T21:12:15Z
dc.date.issued2018
dc.departmentNEÜ, Meram Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Radyasyon Onkolojisi Bölümü, Anabilim Dalıen_US
dc.departmentNEÜ, Meram Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Tıbbi Patoloji Anabilim Dalıen_US
dc.descriptionWOS:000446223100006en_US
dc.descriptionPubMed ID:30288496en_US
dc.description.abstractObjective: The prognostic importance of extracapsular extension (ECE) in breast cancer is not yet clear, especially in patients with pathologicalT1-2 and N1 (pT1-2N1) disease. We aimed to investigate whether the extent of ECE was an independent prognostic factor for survival outcomesin patients with pT1-2N1 breast cancer.Materials and Methods: A total number of 131 patients with pT1-2N1 breast cancer treated between 2009 and 2015 were retrospectively evaluated. A single pathologist re-analyzed the histologic examples of all cases. The extent of ECE was graded from 0 to 4.Results: There was a significant correlation between the number of lymph nodes involved and ECE grade (p0.004). According to the univariateanalysis, lymphovascular invasion (LVI) and ECE grade were the significant prognostic factors for overall survival (OS); age, number of metastaticlymph nodes, menopausal status, and ECE grade were the prognostic factors for disease-free survival (DFS). With a median follow-up of 46 months,grade 3-4 ECE seems to be notably associated with a shorter OS and DFS in multivariate analysis. The mean OS was 85 months for the patients withgrade 0-2 ECE vs 75 months for the patients with grade 3-4 ECE (p0.003). The mean DFS was 83 months for the patients with grade 0-3 ECE vs68 months for the patients with grade 4 ECE (p0.0001).Conclusion: This research has shown that the extent of ECE is an important prognostic factor for survival in pT1-2N1 breast cancer patients andgrade 3-4 ECE seems to be notably associated with a shorter OS and DFS.en_US
dc.identifier.citationKanyılmaz, G., Fındık, S., Yavuz, B. B., Aktan, M. (2018). The significance of extent of extracapsular extension in patients with T1-2 and N1 breast cancer. European Journal of Breast Health, 14, 4, 218-224.en_US
dc.identifier.doi10.5152/ejbh.2018.4038en_US
dc.identifier.endpage224en_US
dc.identifier.issn2587-0831en_US
dc.identifier.issue4en_US
dc.identifier.pmid30288496en_US
dc.identifier.startpage218en_US
dc.identifier.urihttps://dx.doi.org/10.5152/ejbh.2018.4038
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TXpBek1Ua3pNdz09/the-significance-of-extent-of-extracapsular-extension-in-patients-with-t1-2-and-n1-breast-cancer
dc.identifier.urihttps://hdl.handle.net/20.500.12452/2735
dc.identifier.volume14en_US
dc.identifier.wosWOS:000446223100006en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofEuropean Journal of Breast Healthen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US]
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAxillary lymph node metastasesen_US
dc.subjectBreast canceren_US
dc.subjectExtracapsular extensionen_US
dc.subjectRadiotherapyen_US
dc.subjectPrognosisen_US
dc.titleThe Significance of Extent of Extracapsular Extension in Patients with T1-2 and N1 Breast Canceren_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Kanyılmaz, Gül.pdf
Boyut:
311.52 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin/ Full Text
İndir

Koleksiyon

TR-Dizin İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
Makale Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu