Evaluation of the effectiveness of biodegradable electrospun caprolactoneand poly(lactic acid-?-caprolactone) nerve conduits for peripheral nerveregenerations in a rat sciatic nerve defect model

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dc.authoridMehmet Dadacı: 37550
dc.authoridBilsev İnce: 0000-0002-1756-4131
dc.authoridNimet Karagülle: 0000-0003-3162-0803
dc.authoridErhan Sönmez: 0000-0003-2641-6410
dc.authoridİbrahim Vargel: 0000-0002-7657-8170
dc.authoridErhan Pişkin: 0000-0001-6580-7364
dc.contributor.authorDadacı, Mehmet
dc.contributor.authorİnce, Bilsev
dc.contributor.authorKaragülle, Nimet
dc.contributor.authorSönmez, Erhan
dc.contributor.authorDadacı, Zeynep
dc.contributor.authorİşci, Evren Tevfik
dc.contributor.authorVargel, İbrahim
dc.contributor.authorPişkin, Erhan
dc.contributor.authorErk, Ali Yücel
dc.date.accessioned2020-01-18T21:02:51Z
dc.date.available2020-01-18T21:02:51Z
dc.date.issued2016
dc.departmentNEÜ, Meram Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Plastik, Rekonstrüktif ve Estetik Cerrahi Anabilim Dalıen_US
dc.description.abstractBackground/aim: The aim of this study was to compare electrospun caprolactone (EC) and poly(lactic acid-?-caprolactone) (PLCL) nerve conduits with nerve graft in a rat sciatic nerve defect model. Materials and methods: A total of 32 male Wistar albino rats were divided into 4 groups, with 8 rats in each group. A nerve defect of 1 cm was constructed in the left sciatic nerve of the rats. These defects were left denuded in the sham group, and reconstructed with nerve grafts, PLCL, and EC nerve conduits in the other groups. After 3 months, nerve regenerations were evaluated macroscopically, microscopically, and electrophysiologically. The numbers of myelinated axons in the cross-sections of the nerves were compared between the groups. Results: Macroscopically, all nerve coaptations were intact and biodegradation was detected in nerve conduits. Electromyographic assessment and count of myelinated axons in the cross-sections of the nerves displayed the best regeneration in the nerve graft group (P0.001) and similar results were obtained in the PLCL and EC nerve conduit groups (P0.79). Light and electron microscopy studies demonstrated nerve regeneration in both nerve conduit groups. Conclusion: EC nerve conduits and PLCL nerve conduits yielded similar results and may be alternatives to nerve grafts as they biodegrade.en_US
dc.identifier.citationDadacı, M., İnce, B., Karagülle, N., Sönmez, E., Dadacı, Z., İşci, E. T., Vargel, İ., Pişkin, E., Erk, A. Y. (2016). Evaluation of the effectiveness of biodegradable electrospun caprolactoneand poly(lactic acid-?-caprolactone) nerve conduits for peripheral nerveregenerations in a rat sciatic nerve defect model. Turkish Journal of Medical Sciences, 46, 2, 539-548.
dc.identifier.endpage548en_US
dc.identifier.issn1300-0144en_US
dc.identifier.issn1303-6165en_US
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage539en_US
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TWpRNE1qWXhNUT09/evaluation-of-the-effectiveness-of-biodegradable-electrospun-caprolactoneand-poly-lactic-acid-caprolactone-nerve-conduits-for-peripheral-nerveregenerations-in-a-rat-sciatic-nerve-defect-model
dc.identifier.urihttps://hdl.handle.net/20.500.12452/1323
dc.identifier.volume46en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US]
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectNerve regenerationen_US
dc.subjectNerve graften_US
dc.subjectElectrospun caprolactone nerve conduitsen_US
dc.subjectPoly(DL-lactide-?-caprolactone) nerve conduitsen_US
dc.titleEvaluation of the effectiveness of biodegradable electrospun caprolactoneand poly(lactic acid-?-caprolactone) nerve conduits for peripheral nerveregenerations in a rat sciatic nerve defect modelen_US
dc.typeArticleen_US

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