Use of Systemic Rosmarinus Officinalis to Enhance the Survival of Random-Pattern Skin Flaps
Yükleniyor...
Dosyalar
Tarih
2016
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Background: Skin flaps are commonly used in softtissue reconstruction; however, necrosis can be a frequent complication. Several systemic and local agents have been used in attempts to improve skin flap survival, but none that can prevent flap necrosis have been identified. Aims: This study aims to determine whether the use of systemic Rosmarinus officinalis (R. officinalis) extract can prevent flap necrosis and improve skin flap recovery. Study Design: Animal experimentation. Methods: Thirty-five Wistar albino rats were divided in five groups. A rectangular random-pattern flaps measuring 8×2 cm was elevated from the back of each rat. Group I was the control group. In Group II, 0.2 ml of R. officinalis oil was given orally 2h before surgery. R. officinalis oil was then applied orally twice a day for a week. In Group III, R. officinalis oil was given orally twice a day for one week before surgery. At the end of the week, 0.2 mL of R. officinalis oil was given orally 2 h before surgery. In Group IV, 0.2 mL of R. officinalis oil was injected subcutaneously 2 h before surgery. After the surgery, 0.2 mL R. officinalis oil was injected subcutaneously twice a day for one week. In Group V, 0.2 mL R. officinalis oil was injected subcutaneously twice a day for one week prior to surgery. At the end of the week, one last 0.2 mL R. officinalis oil injection was administered subcutaneously 2 h before surgery. After the surgery, 0.2 mL R. officinalis oil was injected subcutaneously twice a day for one week. Results: The mean percentage of viable surface area was significantly greater (p>0.05) in Groups II, III, IV, and V as compared to Group I. Mean vessel diameter was significantly greater (p>0.05) in Groups II, III, IV, and V as compared to Group I. Conclusion: We have determined that, in addition to its anti-inflammatory and anti-oxidant effects, R. officinalis has vasodilatory effects that contribute to increased skin flap survival.
Açıklama
Anahtar Kelimeler
Cerrahi, Rosmarinus Officinalis, Flap Survivability, Tissue Defect, Rosemary
Kaynak
Balkan Medical Journal
WoS Q Değeri
Q3
Scopus Q Değeri
Q3
Cilt
33
Sayı
6
Künye
İnce, B., Bilgen, F., Gündeslioğlu, A. O., Dadacı, M., Kozacıoğlu, S. (2016). Use of Systemic Rosmarinus Officinalis to Enhance the Survival of Random-Pattern Skin Flaps. Balkan Medical Journal, 33, 6, 645-651.
