Use of Systemic Rosmarinus Officinalis to Enhance the Survival of Random-Pattern Skin Flaps

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dc.authorid0000-0002-1756-4131en_US
dc.contributor.authorİnce, Bilsev
dc.contributor.authorBilgen, Fatma
dc.contributor.authorGündeşlioğlu, Ayşe Özlem
dc.contributor.authorDadacı, Mehmet
dc.contributor.authorKozacıoğlu, Sümeyye
dc.date.accessioned2020-01-18T21:02:53Z
dc.date.available2020-01-18T21:02:53Z
dc.date.issued2016
dc.departmentNEÜ, Meram Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Plastik Cerrahi Anabilim Dalıen_US
dc.description.abstractBackground: Skin flaps are commonly used in softtissue reconstruction; however, necrosis can be a frequent complication. Several systemic and local agents have been used in attempts to improve skin flap survival, but none that can prevent flap necrosis have been identified. Aims: This study aims to determine whether the use of systemic Rosmarinus officinalis (R. officinalis) extract can prevent flap necrosis and improve skin flap recovery. Study Design: Animal experimentation. Methods: Thirty-five Wistar albino rats were divided in five groups. A rectangular random-pattern flaps measuring 8×2 cm was elevated from the back of each rat. Group I was the control group. In Group II, 0.2 ml of R. officinalis oil was given orally 2h before surgery. R. officinalis oil was then applied orally twice a day for a week. In Group III, R. officinalis oil was given orally twice a day for one week before surgery. At the end of the week, 0.2 mL of R. officinalis oil was given orally 2 h before surgery. In Group IV, 0.2 mL of R. officinalis oil was injected subcutaneously 2 h before surgery. After the surgery, 0.2 mL R. officinalis oil was injected subcutaneously twice a day for one week. In Group V, 0.2 mL R. officinalis oil was injected subcutaneously twice a day for one week prior to surgery. At the end of the week, one last 0.2 mL R. officinalis oil injection was administered subcutaneously 2 h before surgery. After the surgery, 0.2 mL R. officinalis oil was injected subcutaneously twice a day for one week. Results: The mean percentage of viable surface area was significantly greater (p>0.05) in Groups II, III, IV, and V as compared to Group I. Mean vessel diameter was significantly greater (p>0.05) in Groups II, III, IV, and V as compared to Group I. Conclusion: We have determined that, in addition to its anti-inflammatory and anti-oxidant effects, R. officinalis has vasodilatory effects that contribute to increased skin flap survival.en_US
dc.identifier.citationİnce, B., Bilgen, F., Gündeslioğlu, A. O., Dadacı, M., Kozacıoğlu, S. (2016). Use of Systemic Rosmarinus Officinalis to Enhance the Survival of Random-Pattern Skin Flaps. Balkan Medical Journal, 33, 6, 645-651.en_US
dc.identifier.doi10.5152/balkanmedj.2016.150981en_US
dc.identifier.endpage651en_US
dc.identifier.issn2146-3123en_US
dc.identifier.issn2146-3131en_US
dc.identifier.issue6en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage645en_US
dc.identifier.urihttp://app.trdizin.gov.tr/publication/paper/detail/TWpJd09USTNOdz09
dc.identifier.urihttps://hdl.handle.net/20.500.12452/1336
dc.identifier.volume33en_US
dc.identifier.wosWOS:000396360400010en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofBalkan Medical Journalen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US]
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCerrahien_US
dc.subjectRosmarinus Officinalisen_US
dc.subjectFlap Survivabilityen_US
dc.subjectTissue Defecten_US
dc.subjectRosemaryen_US
dc.titleUse of Systemic Rosmarinus Officinalis to Enhance the Survival of Random-Pattern Skin Flapsen_US
dc.typeArticleen_US

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